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  4. Recombinant Rat POU domain, class 4, transcription factor 1 (Pou4f1)

Recombinant Rat POU domain, class 4, transcription factor 1 (Pou4f1)

  • 中文名称：
    大鼠Pou4f1重组蛋白
  • 货号：
    CSB-YP018400RA
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    大鼠Pou4f1重组蛋白
  • 货号：
    CSB-EP018400RA
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    大鼠Pou4f1重组蛋白
  • 货号：
    CSB-EP018400RA-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    大鼠Pou4f1重组蛋白
  • 货号：
    CSB-BP018400RA
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    大鼠Pou4f1重组蛋白
  • 货号：
    CSB-MP018400RA
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Pou4f1
  • Uniprot No.：
    P20266
  • 别名：
    Pou4f1; Brn-3; Brn3; Brn3a; POU domain; class 4; transcription factor 1; Brain-specific homeobox/POU domain protein 3A; Brain-3A; Brn-3A
  • 种属：
    Rattus norvegicus (Rat)
  • 蛋白长度：
    Full length protein
  • 表达区域：
    1-128
  • 氨基酸序列
    RRIKLGVTQA DVGSALANLK IPGVGSLSQS TICRFESLTL SHNNMIALKP ILQAWLEEAE GAQREKMNKP ELFNGGEKKR KRTSIAAPEK RSLEAYFAVQ PRPSSEKIAA IAEKLDLKKN VVRVWFCN
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Multifunctional transcription factor with different regions mediating its different effects. Acts by binding (via its C-terminal domain) to sequences related to the consensus octamer motif 5'-ATGCAAAT-3' in the regulatory regions of its target genes. Regulates the expression of specific genes involved in differentiation and survival within a subset of neuronal lineages. It has been shown that activation of some of these genes requires its N-terminal domain, maybe through a neuronal-specific cofactor. Ativates BCL2 expression and protects neuronal cells from apoptosis (via the N-terminal domain). Induces neuronal process outgrowth and the coordinate expression of genes encoding synaptic proteins. Exerts its major developmental effects in somatosensory neurons and in brainstem nuclei involved in motor control. Stimulates the binding affinity of the nuclear estrogene receptor ESR1 to DNA estrogen response element (ERE), and hence modulates ESR1-induced transcriptional activity. May positively regulate POU4F2 and POU4F3. Regulates dorsal root ganglion sensory neuron specification and axonal projection into the spinal cord. Plays a role in TNFSF11-mediated terminal osteoclast differentiation. Negatively regulates its own expression interacting directly with a highly conserved autoregulatory domain surrounding the transcription initiation site.; Able to act as transcription factor, cannot regulate the expression of the same subset of genes than isoform 1. Does not have anitapoptotic effect on neuronal cells.
  • 基因功能参考文献：
    1. phenotypic and molecular changes that may represent an effort to resist degeneration and/or preferential survival of m+RGCs capable of synthesizing Brn3a. PMID: 26200499
    2. Brn3a is a reliable retinal ganglion cell marker that can be used to accurately measure the potential effect of a given neuroprotective therapy. PMID: 21315070
    3. Prenatal lead exposure caused a significant decrease in Brn-3a mRNA transcription in neural cells from cerebral hippocampus. PMID: 18839516
    4. Brn-3a mRNA transcription level significantly decreased in neural cells from cerebral hippocampus in all lead treatment groups compared with the control group. PMID: 18303621
    5. data define AR as a direct Brn-3a interactor and verify a simple interacting protein prediction methodology that is likely to be useful for many other proteins PMID: 20228055
    6. Brn-3a activates transcription of anti-apoptotic genes in retinal ganglion cells. PMID: 15968082

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  • 亚细胞定位：
    Nucleus. Cytoplasm.
  • 蛋白家族：
    POU transcription factor family, Class-4 subfamily
  • 组织特异性：
    Detected in brain, spinal cord and dorsal root ganglion. Isoform 2 is detected in brain, spinal cord, dorsal root ganglion and spleen.
  • 数据库链接：

    KEGG: rno:114503

    STRING: 10116.ENSRNOP00000012828

    UniGene: Rn.232568

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