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  4. Recombinant Rat Nucleolar protein 3 (Nol3)

Recombinant Rat Nucleolar protein 3 (Nol3)

  • 中文名称：
    大鼠Nol3重组蛋白
  • 货号：
    CSB-YP717288RA
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    大鼠Nol3重组蛋白
  • 货号：
    CSB-EP717288RA
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    大鼠Nol3重组蛋白
  • 货号：
    CSB-EP717288RA-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    大鼠Nol3重组蛋白
  • 货号：
    CSB-BP717288RA
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    大鼠Nol3重组蛋白
  • 货号：
    CSB-MP717288RA
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Nol3
  • Uniprot No.：
    Q62881
  • 别名：
    Nol3; ArcNucleolar protein 3; Apoptosis repressor with CARD
  • 种属：
    Rattus norvegicus (Rat)
  • 蛋白长度：
    full length protein
  • 表达区域：
    1-221
  • 氨基酸序列
    MGNMQERPSE TIDRERKRLV ETLQADSGLL LDALVARGVL TGPEYEALDA LPDAERRVRR LLLLVQSKGE AACQELLRCA QQTVSMPDPA WDWQHVGPGY RDRSYDPPCP GHWTPEAPSS GTTCPGLPRA SEEEEIGGPE DSEAVQPRTP EEPELEAEAT KGDEPDLEQE MEPEPEPEVE PEPEPEPEPE PEPEPEPEPE PEPEREPDFQ EGDESEGCEN T
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Apoptosis repressor that blocks multiple modes of cell death. Inhibits extrinsic apoptotic pathways through two different ways. Firstly by interacting with FAS and FADD upon FAS activation blocking death-inducing signaling complex (DISC) assembly. Secondly by interacting with CASP8 in a mitochondria localization- and phosphorylation-dependent manner, limiting the amount of soluble CASP8 available for DISC-mediated activation. Inhibits intrinsic apoptotic pathway in response to a wide range of stresses, through its interaction with BAX resulting in BAX inactivation, preventing mitochondrial dysfunction and release of pro-apoptotic factors. Inhibits calcium-mediated cell death by functioning as a cytosolic calcium buffer, dissociating its interaction with CASP8 and maintaining calcium homeostasis. Negatively regulates oxidative stress-induced apoptosis by phosphorylation-dependent suppression of the mitochondria-mediated intrinsic pathway, by blocking CASP2 activation and BAX translocation. Negatively regulates hypoxia-induced apoptosis in part by inhibiting the release of cytochrome c from mitochondria in a caspase-independent manner. Also inhibits TNF-induced necrosis by preventing TNF-signaling pathway through TNFRSF1A interaction abrogating the recruitment of RIPK1 to complex I. Finally through its role as apoptosis repressor, promotes vascular remodeling through inhibition of apoptosis and stimulation of proliferation, in response to hypoxia. Inhibits too myoblast differentiation through caspase inhibition.
  • 基因功能参考文献：
    1. The results of the present study revealed that ARC inhibition promotes the apoptosis of pulmonary arterial smooth muscle cells. PMID: 28731195
    2. Foxo3a maintains calcium homeostasis and inhibits cardiac apoptosis through trans-activation of the ARC promoter. PMID: 23382383
    3. Data show that low-dose mineralocorticoid receptor antagonists reduce infarct size and apoptosis in the reperfused myocardium by preventing the apoptosis repressor with caspase recruitment domain (ARC) degradation. PMID: 22508833
    4. A novel cardiac pathway is identified in which anesthetic preconditioning results in increased phosphorylation of nucleolar protein 3 following inhibition of calcineurin increase. PMID: 21233493
    5. ARC protein is expressed in vascular smooth muscle and is significantly reduced in several target tissues during hypertension. PMID: 20026055
    6. Down-regulation of ARC contributes to vulnerability of hippocampal neurons to ischemia/hypoxia PMID: 12753927
    7. mitochondrial ARC levels increased with age and were lower in calorie-restricted rats than in age-matched controls PMID: 14732288
    8. ARC can protect against cell death by interfering with activation of the mitochondrial death pathway through the interaction with Bax, preventing mitochondrial dysfunction and release of pro-apoptotic factors. PMID: 15004034
    9. Unexpectedly, ARC was localized almost exclusively to the nuclei of cancer cells, which was unlike the cytoplasmic localization of ARC in non-cancer cells PMID: 15848180
    10. ARC-overexpression inhibited myoblast differentiation associated caspase-3 activation, suggesting ARC inhibits myogenic differentiation through caspase inhibition. PMID: 17292893
    11. preconditioning-induced suppression of the release of mitochondrial cytochrome c to cytosol and caspase-3 activation could be abolished by the inhibition of endogenous ARC expression using ARC antisense oligonucleotides. PMID: 17594520
    12. reveal a novel p53 apoptotic pathway in which it initiates apoptosis by transcriptionally repressing ARC PMID: 17998337
    13. catalase, CK2, and ARC constitute an anti-hypertrophic pathway in the heart. PMID: 18171680
    14. Novel cardiac apoptotic pathway in which ARC is dephosphorylated by calcineurin, which could be a component in the cardiac apoptotic machinery. PMID: 19001025
    15. ARC plays an essential role in mediating the cardioprotective effect of postconditioning against apoptosis initiated by the mitochondrial pathway. PMID: 19130235
    16. Studies provide evidence for the protective role of anti-apoptotic ARC in Dox-induced cardiotoxicity, which makes this molecule an interesting target for future therapies. PMID: 19139834
    17. Down-regulation of ARC (apoptosis repressor with caspase recruitment domain) contributes to vulnerability of hippocampal neurons to ischemia/hypoxia. PMID: 12753927

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  • 亚细胞定位：
    Cytoplasm. Mitochondrion. Sarcoplasmic reticulum. Membrane; Lipid-anchor.
  • 组织特异性：
    Highly expressed in skeletal muscle, heart and medulla.
  • 数据库链接：

    KEGG: rno:85383

    UniGene: Rn.86956

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