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  4. Recombinant Rat Neuropilin-1 (Nrp1), partial

Recombinant Rat Neuropilin-1 (Nrp1), partial

  • 中文名称：
    大鼠Nrp1重组蛋白
  • 货号：
    CSB-YP879432RA
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    大鼠Nrp1重组蛋白
  • 货号：
    CSB-EP879432RA
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    大鼠Nrp1重组蛋白
  • 货号：
    CSB-EP879432RA-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    大鼠Nrp1重组蛋白
  • 货号：
    CSB-BP879432RA
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    大鼠Nrp1重组蛋白
  • 货号：
    CSB-MP879432RA
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Nrp1
  • Uniprot No.：
    Q9QWJ9
  • 别名：
    Nrp1; Neuropilin-1; Vascular endothelial cell growth factor 165 receptor; CD antigen CD304
  • 种属：
    Rattus norvegicus (Rat)
  • 蛋白长度：
    Partial
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Cell-surface receptor involved in the development of the cardiovascular system, in angiogenesis, in the formation of certain neuronal circuits and in organogenesis outside the nervous system. Mediates the chemorepulsant activity of semaphorins. Recognizes a C-end rule (CendR) motif R/KXXR/K on its ligands which causes cellular internalization and vascular leakage. It binds to semaphorin 3A, the PLGF-2 isoform of PGF, the VEGF165 isoform of VEGFA and VEGFB. Coexpression with KDR results in increased VEGF165 binding to KDR as well as increased chemotaxis. Regulates VEGF-induced angiogenesis. Binding to VEGFA initiates a signaling pathway needed for motor neuron axon guidance and cell body migration, including for the caudal migration of facial motor neurons from rhombomere 4 to rhombomere 6 during embryonic development. Regulates mitochondrial iron transport via interaction with ABCB8/MITOSUR.
  • 基因功能参考文献：
    1. important role in the regulation of neointimal hyperplasia by modulating vascular smooth muscle cell migration PMID: 26410366
    2. The results of the present study suggest that some soluble factors from smooth muscle cells may affect the localization of Nrp-1 in cholinergic neuronal cells, which may, in turn, be involved in the autonomic innervation of blood vessels. PMID: 25416424
    3. Nrp1-deficient vessels have reduced VEGFR2 surface expression in vivo demonstrating that NRP1 regulates its co-receptor, VEGFR2. PMID: 25244320
    4. The expressions of neuropilin-1 (NRP-1) on glioma cell lines and glioma tissues, were investigated. PMID: 23621014
    5. Neuropilin 1 (NPR1) and not Plexin A (PlexA), protein expression increased in the dorsal spinal cord of chronic constriction injury (CCI) rats. PMID: 20888378
    6. soluble recombinant rNRP-1 is a VEGF-A(165)-independent agonist of VEGFR-2 and stimulates angiogenesis in endothelial cells PMID: 20956519
    7. Neuropilin-1 mRNA showed no changed expression in axotomized motoneurons. PMID: 15094469
    8. NP-1 has a specific role in mediating neurotrophic actions of VEGF family members PMID: 15126502
    9. Data show that Npn-1 can potentiate the growth-stimulatory activity of FGF-2 on human umbilical vein endothelial cells, indicating that Npn-1 may not just bind but also regulate the activity of heparin-binding proteins. PMID: 15695515
    10. After spinal crush and rhizotomy, Np1 is expressed de novo around the injury and in the deafferentated dorsal horn, respectively, mainly by OX42-positive microglial cells. PMID: 15737738
    11. Nrp1 is a receptor for TGF-beta1, activates its latent form, and is relevant to regulatory T cell activity and tumor biology. PMID: 18436584

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  • 亚细胞定位：
    Mitochondrion membrane; Single-pass type I membrane protein. Cell membrane; Single-pass type I membrane protein. Cytoplasm.
  • 蛋白家族：
    Neuropilin family
  • 组织特异性：
    Found in the embryonic nervous system. Expressed in dorsal root ganglia.
  • 数据库链接：

    KEGG: rno:246331

    STRING: 10116.ENSRNOP00000014492

    UniGene: Rn.10815

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