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  4. Recombinant Rat Neurogenic locus notch homolog protein 3 (Notch3), partial

Recombinant Rat Neurogenic locus notch homolog protein 3 (Notch3), partial

  • 中文名称：
    大鼠Notch3重组蛋白
  • 货号：
    CSB-YP865638RA
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    大鼠Notch3重组蛋白
  • 货号：
    CSB-EP865638RA
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    大鼠Notch3重组蛋白
  • 货号：
    CSB-EP865638RA-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    大鼠Notch3重组蛋白
  • 货号：
    CSB-BP865638RA
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    大鼠Notch3重组蛋白
  • 货号：
    CSB-MP865638RA
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Notch3
  • Uniprot No.：
    Q9R172
  • 别名：
    Notch3; Neurogenic locus notch homolog protein 3; Notch 3) [Cleaved into: Notch 3 extracellular truncation; Notch 3 intracellular domain]
  • 种属：
    Rattus norvegicus (Rat)
  • 蛋白长度：
    Partial
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Functions as a receptor for membrane-bound ligands Jagged1, Jagged2 and Delta1 to regulate cell-fate determination. Upon ligand activation through the released notch intracellular domain (NICD) it forms a transcriptional activator complex with RBPJ/RBPSUH and activates genes of the enhancer of split locus. Affects the implementation of differentiation, proliferation and apoptotic programs. Acts instructively to control the cell fate determination of CNS multipotent progenitor cells, resulting in astroglial induction and neuron/oligodendrocyte suppression.
  • 基因功能参考文献：
    1. mild hypothermia inhibits Notch 3 and Notch 4 activation and seizure after stroke in the rat model PMID: 29754932
    2. Cysteine-sparing NOTCH3 missense mutations are associated with typical clinical CADASIL syndrome and typical magnetic resonance imaging (MRI) findings, although with less involvement of the anterior temporal lobe. PMID: 28902129
    3. We find that across species, the atypical receptor NOTCH3 is differentially overexpressed; it is progressively up-regulated with disease development and promotes tumor cell survival via activation of PI3k-Akt PMID: 27791012
    4. Notch3 signaling activation stimulated pulmonary vascular cells proliferation. PMID: 26317171
    5. Notch3, Jagged1, Hes1 and alpha-SMA were downregulated. This downregulation was accompanied by improved hepatic fibrosis after the inhibition of Notch3 in vivo. PMID: 23918872
    6. Notch-3 receptor activation drives inflammation and fibrosis following tubulointerstitial kidney injury. PMID: 22806125
    7. These findings imply that Notch3 may not only be a regulator of fetal liver stem/progenitor cells differentiation into hepatocytes, but also be a potential marker of fetal liver stem/progenitor cells. PMID: 22680933
    8. Notch3 signaling in vascular smooth muscle cells induces c-FLIP expression via ERK/MAPK activation PMID: 11925448
    9. These results demonstrate that the Notch3 pathway is attenuated through IL-1beta and through NF-kappaB activation, allowing vascular smooth muscle cells to switch into an inflammatory state. PMID: 17881497
    10. Data demonstrate that extracellular YB-1 associates with outer cell membrane components and interacts with extracellular Notch-3 receptor domains. PMID: 19640841

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  • 亚细胞定位：
    Cell membrane; Single-pass type I membrane protein.; [Notch 3 intracellular domain]: Nucleus. Note=Following proteolytical processing NICD is translocated to the nucleus.
  • 蛋白家族：
    NOTCH family
  • 组织特异性：
    Expressed in postnatal central nervous system (CNS) germinal zones and, in early postnatal life, within numerous cells throughout the CNS. It is more highly localized to ventricular germinal zones.
  • 数据库链接：

    KEGG: rno:56761

    STRING: 10116.ENSRNOP00000037570

    UniGene: Rn.228683

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