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  4. Recombinant Rat Neurabin-2 (Ppp1r9b), partial

Recombinant Rat Neurabin-2 (Ppp1r9b), partial

  • 中文名称：
    大鼠Ppp1r9b重组蛋白
  • 货号：
    CSB-YP018558RA
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    大鼠Ppp1r9b重组蛋白
  • 货号：
    CSB-EP018558RA
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    大鼠Ppp1r9b重组蛋白
  • 货号：
    CSB-EP018558RA-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    大鼠Ppp1r9b重组蛋白
  • 货号：
    CSB-BP018558RA
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    大鼠Ppp1r9b重组蛋白
  • 货号：
    CSB-MP018558RA
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Ppp1r9b
  • Uniprot No.：
    O35274
  • 别名：
    Ppp1r9b; Spino; Neurabin-2; Neurabin-II; Neural tissue-specific F-actin-binding protein II; PP1bp134; Protein phosphatase 1 regulatory subunit 9B; Spinophilin; p130
  • 种属：
    Rattus norvegicus (Rat)
  • 蛋白长度：
    Partial
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Seems to act as a scaffold protein in multiple signaling pathways. Modulates excitatory synaptic transmission and dendritic spine morphology. Binds to actin filaments (F-actin) and shows cross-linking activity. Binds along the sides of the F-actin. May play an important role in linking the actin cytoskeleton to the plasma membrane at the synaptic junction. Believed to target protein phosphatase 1/PP1 to dendritic spines, which are rich in F-actin, and regulates its specificity toward ion channels and other substrates, such as AMPA-type and NMDA-type glutamate receptors. Plays a role in regulation of G-protein coupled receptor signaling, including dopamine D2 receptors and alpha-adrenergic receptors. May establish a signaling complex for dopaminergic neurotransmission through D2 receptors by linking receptors downstream signaling molecules and the actin cytoskeleton. Binds to ADRA1B and RGS2 and mediates regulation of ADRA1B signaling. May confer to Rac signaling specificity by binding to both, RacGEFs and Rac effector proteins. Probably regulates p70 S6 kinase activity by forming a complex with TIAM1. Required for hepatocyte growth factor (HGF)-induced cell migration.
  • 基因功能参考文献：
    1. At 1 d after acute foodshake-stress Spinophilin was significantly increased in At 1 d after desipramine-treated animals as compared to vehicle-treated animals. PMID: 27890541
    2. The guanine nucleotide exchange factor (GEF) Asef2 promotes dendritic spine formation via Rac activation and spinophilin-dependent targeting. PMID: 25750125
    3. The current results suggest a possible role for spinophilin in neuronal plasticity induced by environmental enrichment. PMID: 20385205
    4. endogenous neurabin II and I-2 colocalized at actin-rich structures, consistent with the ability of neurabins to target the PP1.I-2 complex to actin cytoskeleton and regulate cell morphology PMID: 12270929
    5. phosphorylation of spinophilin by PKA modulates the anchoring of the spinophilin-PP1 complex within dendritic spines, thereby likely contributing to the efficacy and plasticity of synaptic transmission. PMID: 12417592
    6. spinophilin binding promotes the plasma membrane localization of Tiam1 and enhances the ability of Tiam1 to activate p70 S6 kinase PMID: 12531897
    7. Regions of spinophilin that lack the revised Actin-binding Domain (ABD) do not co-localize with phalloidin-labeled actin, suggesting that the ABD contributes to directing the subcellular distribution of spinophilin. PMID: 15135218
    8. These results indicate that spinophilin is phosphorylated by multiple kinases in vivo and that differential phosphorylation may target spinophilin to specific locations within dendritic spines PMID: 15228588
    9. The functional role of spinophilin may not be exclusively restricted to excitatory synapses and may be significant at a small fraction of inhibitory contacts. PMID: 15514983
    10. Associatively conditioned rats had more spinophilin in their dendritic spines than controls; changes in the number of dendritic spines must occur during learning and account in part for memory. PMID: 16930415
    11. selective targeting of PP1gamma1 to F-actin by neurabins in intact cells requires both the canonical PP1-binding motif and an auxiliary PP1gamma1-selectivity determinant PMID: 18216290
    12. expression of spinophilin (SPL) could enhance the regulatory function of RGS8 on the M3-mAChR system, but the acceleration function of RGS8 on the M2-mediated signaling could not be enhanced by SPL PMID: 19609226

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  • 亚细胞定位：
    Cytoplasm, cytoskeleton. Nucleus. Cell junction, synapse, postsynaptic density. Cell junction, adherens junction. Cell projection, dendritic spine. Cytoplasm. Cell membrane. Cell projection, lamellipodium. Cell projection, filopodium. Cell projection, ruffle membrane.
  • 组织特异性：
    Ubiquitous. Abundantly expressed in the brain. Expressed at highest levels in hippocampus and at lower levels in the cortex, cerebellum and brainstem. Localizes to the dendritic spines of neurons. Also localizes to aspiny neurons, such as GABAergic intern
  • 数据库链接：

    KEGG: rno:84686

    STRING: 10116.ENSRNOP00000005498

    UniGene: Rn.6764

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