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  4. Recombinant Rat Nephrin (Nphs1), partial

Recombinant Rat Nephrin (Nphs1), partial

  • 中文名称：
    大鼠Nphs1重组蛋白
  • 货号：
    CSB-YP879487RA
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    大鼠Nphs1重组蛋白
  • 货号：
    CSB-EP879487RA
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    大鼠Nphs1重组蛋白
  • 货号：
    CSB-EP879487RA-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    大鼠Nphs1重组蛋白
  • 货号：
    CSB-BP879487RA
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    大鼠Nphs1重组蛋白
  • 货号：
    CSB-MP879487RA
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Nphs1
  • Uniprot No.：
    Q9R044
  • 别名：
    Nphs1; Nphn; Nephrin; Renal glomerulus-specific cell adhesion receptor
  • 种属：
    Rattus norvegicus (Rat)
  • 蛋白长度：
    Partial
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

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靶点详情

  • 功能：
    Seems to play a role in the development or function of the kidney glomerular filtration barrier. Regulates glomerular vascular permeability. May anchor the podocyte slit diaphragm to the actin cytoskeleton. Plays a role in skeletal muscle formation through regulation of myoblast fusion.
  • 基因功能参考文献：
    1. Data show that metformin provides some protection against podocyte damage in diabetic rats, which may be related, in part, to its effect in reducing urinary nephrin (Nphs1) excretion as well as improving podocyte nephrin expression. PMID: 27248136
    2. The effects of sildenafil citrate on urinary podocin and nephrin mRNA expression in an L-NAME model of pre-eclampsia. PMID: 27995418
    3. Irbesartan treatment ameliorates proteinuria in puromycin aminonucleoside nephropathy by inhibiting the reduction of NEPH1 and nephrin in the kidney glomerulus. PMID: 25298195
    4. These findings suggest that candesartan can prevent cisplatin-induced testicular damage by regulating expression patterns of the nephrin-podocin complex in the testes. PMID: 26539476
    5. Rat nephrin Tyr1127 and Tyr1152 are essential for SHP-1 induced nephrin dephosphorylation under high-glucose conditions. PMID: 25404734
    6. Resveratrol alleviated dyslipidemia and renal damage induced by high-fat diet also reduced TNF-alpha and MCP-1 levels, and reduced expressions of nephrin and podocin. PMID: 25025298
    7. findings show that the filament-forming GTPase septin 7 is expressed in podocytes and associates with CD2-associated protein (CD2AP) and nephrin, both essential for glomerular ultrafiltration PMID: 22809625
    8. Soy protein preserves basement membrane integrity through a synergistic effect on nephrin, matrix metalloproteinase and vascular endothelial growth factor PMID: 22094487
    9. Huaiqihuang Granule can up-regulate the expressions of nephrin and podocin in renal tissues of rats with adriamycin-induced nephrosis. PMID: 21565142
    10. The decrease of nephrin expression and the change of its distribution might be the significant factors resulting in considerable proteinuria. PMID: 20629321
    11. Abnormal expression of nephrin is the important molecular mechanism that leads to the occurrence and development of proteinuria. PMID: 20045917
    12. These observations indicate that podocyte-specific expression of rat nephrin can rescue nephrin-deficient mice from perinatal death, but is not sufficient for full complementation. PMID: 19948823
    13. nephrin anchors the slit diaphragm to the actin cytoskeleton, possibly by linkage to CD2AP PMID: 11880318
    14. reduction in nephrin may be a determinant of glomerular hyperpermeability in diabetic nephropathy PMID: 12105259
    15. in normotensive and hypertensive rats, nephrin expression increased from birth to the adult age and down-regulation of nephrin in SHR evident from the early developmental kidney to adulthood may contribute to the development of albuminuria in adult SHR. PMID: 12109777
    16. Expression of nephrin in proteinuric states and in developing glomeruli. Review. PMID: 12386277
    17. Depletion in glomerular nephrin expression in diabetic animals was only abrogated by valsartan treatment, the therapy which was most effective at retarding the development of albuminuria in this model. PMID: 12544453
    18. Nephrin and Neph1 form a hetero-oligomeric receptor complex in the plane of the membrane that might interact across the foot process intercellular junction through interactions between Nephrin with itself and Neph1 PMID: 12646566
    19. nephrin and Neph1 interact and have roles in glomerular permeability PMID: 12865409
    20. Onset of proteinuria in passive Heymann nephritis model of membranous nephropathy is coincident with complement-dependent alterations in association of nephrin with actin cytoskeleton and loss of podocyte slit diaphragm integrity. PMID: 14633129
    21. Nephrin expression and its distribution were altered in puromycin aminonucleoside nephrosis in rats. PMID: 15385636
    22. Data show that in glomerulonephritis in rats, an upregulation of nephrin expression occurs with a concomitant transient downregulation of podocin and CD2AP which may account for a highly dysregulated filtration barrier and increased proteinuria. PMID: 15465010
    23. NPHN contributes to a porous slit diaphragm scaffold, the molecular filter in renal glomerular capillaries. PMID: 15545998
    24. Fetal membranes and placenta of the rat express mRNA for the protein barriers nephrin and Neph 1, suggesting a role in the regulation of protein transfer from the fetus to mother PMID: 15979540
    25. Nck couples nephrin to the actin cytoskeleton in glomerular podocytes and contributes to the maintenance of normal morphology and function of podocytes PMID: 16934223
    26. Downregulation of glomerular Nephrin gene expression in minimal-change like nephropathy. PMID: 17429054
    27. Darbepoetin treatment ameliorates podocyte injury and decreases proteinuria by a direct effect on podocytes. This may be accomplished by maintenance of the actin cytoskeleton and nephrin expression. PMID: 17457371
    28. the nephrin gene is differentially expressed according to glomerular size PMID: 17599973
    29. PI3K is involved in nephrin-mediated actin reorganization in podocytes. PMID: 18033240
    30. Tyrosine phosphorylation of nephrin by regulating F-actin formation may be important for the maintenance of normal podocyte morphology and function. PMID: 18256598
    31. Neph1 but not nephrin specifically binds to adaptor protein Grb2 and tyrosine kinase Csk in a phosphorylation-dependent manner. PMID: 18258597
    32. PEDF could reduce proteinuria by suppressing podocyte damage and decreased nephrin as well as increased VEGF expression in the glomeruli of nephrotic syndrome model rats. PMID: 19042927
    33. Nck is required to maintain adult podocytes and phosphotyrosine-based interactions with nephrin may occur in foot processes of resting, mature podocytes. PMID: 19443634

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  • 亚细胞定位：
    Cell membrane; Single-pass type I membrane protein.
  • 蛋白家族：
    Immunoglobulin superfamily
  • 组织特异性：
    Strongly expressed in the podocytes of kidney glomeruli (at protein level) and at lower levels in the spleen.
  • 数据库链接：

    KEGG: rno:64563

    STRING: 10116.ENSRNOP00000049922

    UniGene: Rn.48745

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