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  4. Recombinant Rat NF-kappa-B inhibitor alpha (Nfkbia)

Recombinant Rat NF-kappa-B inhibitor alpha (Nfkbia)

  • 中文名称：
    大鼠Nfkbia重组蛋白
  • 货号：
    CSB-YP733969RA
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    大鼠Nfkbia重组蛋白
  • 货号：
    CSB-EP733969RA
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    大鼠Nfkbia重组蛋白
  • 货号：
    CSB-EP733969RA-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    大鼠Nfkbia重组蛋白
  • 货号：
    CSB-BP733969RA
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    大鼠Nfkbia重组蛋白
  • 货号：
    CSB-MP733969RA
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Nfkbia
  • Uniprot No.：
    Q63746
  • 别名：
    Nfkbia; Ikba; NF-kappa-B inhibitor alpha; I-kappa-B-alpha; IkB-alpha; IkappaBalpha; RL/IF-1
  • 种属：
    Rattus norvegicus (Rat)
  • 蛋白长度：
    full length protein
  • 表达区域：
    1-314
  • 氨基酸序列
    MFQPAGHGQD WAMEGPRDGL KKERLVDDRH DSGLDSMKDE DYEQMVKELR EIRLQPQEAP LAAEPWKQQL TEDGDSFLHL AIIHEEKTLT MEVIGQVKGD LAFLNFQNNL QQTPLHLAVI TNQPGIAEAL LKAGCDPELR DFRGNTPLHL ACEQGCLASV AVLTQTCTPQ HLHSVLQATN YNGHTCLHLA SIHGYLGIVE HLVTLGADVN AQEPCNGRTA LHLAVDLQNP DLVSLLLKCG ADVNRVTYQG YSPYQLTWGR PSTRIQQQLG QLTLENLQTL PESEDEESYD TESEFTEDEL PYDDCVFGGQ RLTL
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Inhibits the activity of dimeric NF-kappa-B/REL complexes by trapping REL dimers in the cytoplasm through masking of their nuclear localization signals. On cellular stimulation by immune and proinflammatory responses, becomes phosphorylated promoting ubiquitination and degradation, enabling the dimeric RELA to translocate to the nucleus and activate transcription.
  • 基因功能参考文献：
    1. Myricetin Possesses Potential Protective Effects on Diabetic Cardiomyopathy through Inhibiting IkappaBalpha/NFkappaB and Enhancing Nrf2/HO-1. PMID: 29147465
    2. Data suggest that expression and phosphorylation of Nfkbia in adipose tissue can be altered by dietary factors; here, obese rats treated with anti-obesity dietary supplement taurine exhibit increased expression of Nfkbia and decreased ratio of phosphorylated/non-phosphorylated Nfkbia intra-abdominal adipose tissue (and decreased adiposity). PMID: 26621632
    3. These results indicated that miR-199b attenuated acute spinal cord injury at least partly through IKKbeta-NF-kappaB signaling pathway and affecting the function of microglia. PMID: 27693495
    4. enhanced miR-381a-3p expression contributed to the injury of osteoarthritis mainly by inhibiting the expression of IkappaBalpha. PMID: 27312547
    5. Thus, the inhibition of the IKK complex might be an effective strategy for the prevention of multiple organ failure associated with hemorrhagic shock PMID: 26101953
    6. TFPI inhibited MCP-3 expression induced by TNF-alpha; this effect may be propagated through the NF-kappaB/IkappaB-alpha pathway. PMID: 23374966
    7. NF-kappaB signaling through IkappaBalpha degradation results in manganese superoxide dismutase (MnSOD) upregulation and preserved cell growth, whereas NF-kappaB signaling through IkappaBbeta degradation mediates apoptosis and P-selectin expression. PMID: 23418625
    8. Data from an obesity model suggest that as duration of plasma free fatty acid elevation increases, the IKKB pathway in liver becomes inactivated leading to insulin resistance; levels of phospho-IkBa and IkBa in liver were monitored in this study. PMID: 23328071
    9. a role for IKKalpha in accelerating the differentiation of human NPCs and identify IKKalpha as a potential regulator of MeCP2 function and BDNF expression PMID: 22848609
    10. These results suggest the existence of a reservoir of monoubiquitylated IkappaBalpha resistant to TNFalpha-induced proteolysis. PMID: 22022389
    11. Redox regulation of IkappaB-alpha nuclear transport and activation in rat PMID: 12200125
    12. basal IkappaBalpha expression (and as a consequence NF-kappaB activity) is under the control of the various components of the CBF1/Notch signal transduction pathway PMID: 12700242
    13. IKBA is degraded by HSP27 through the 26s proteasome PMID: 12897149
    14. IKBA has a role in tumor necrosis factor-stimulated insulin resistance in skeletal muscle PMID: 14764603
    15. anti-inflammatory effects of SP-A on LPS-challenged alveolar macrophages are associated with a SP-A-mediated direct modulation of the IkappaB-alpha turnover PMID: 15308505
    16. diet-induced obesity and acute hyperlipidemia reduce IkappaBalpha levels in rat skeletal muscle in a fiber-type-dependent manner PMID: 16081881
    17. the mechanism preventing septic activation of NF-kappaB is that oversynthesized HSP72 forms a complex with NF-kappaB/I-kappaB, thus inhibiting nuclear translocation of NF-kappaB PMID: 16135962
    18. Results describe the coincident enrichment of phosphorylated IkappaBalpha, activated IKK, and phosphorylated p65 in the axon initial segment of neurons. PMID: 16875840
    19. IkappaBalpha degradation is required for the unloading-induced decrease in fiber size, the increase in protein ubiquitination, activation of NF-kappaB signaling, and the expression of specific atrophy genes PMID: 16928772
    20. data suggest a new mechanism by which calpain 3 activation is able to regulate the IkappaBalpha/NF-kappaB pathway and thus neurodegenerative processes PMID: 16938483
    21. indicate that anti-inflammatory macrophage activation via IkappaB-alpha by Surfactant protein A critically depends on protein kinase C zeta activity PMID: 17878344
    22. alteration of NF-kappaB and I-kappa B might play an important role in aberrant proliferation within the intima and vascular remodeling following vascular injury PMID: 18278452

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  • 亚细胞定位：
    Cytoplasm. Nucleus.
  • 蛋白家族：
    NF-kappa-B inhibitor family
  • 数据库链接：

    KEGG: rno:25493

    STRING: 10116.ENSRNOP00000009894

    UniGene: Rn.12550

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