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  4. Recombinant Rat NACHT, LRR and PYD domains-containing protein 6 (Nlrp6), partial

Recombinant Rat NACHT, LRR and PYD domains-containing protein 6 (Nlrp6), partial

  • 中文名称：
    大鼠Nlrp6重组蛋白
  • 货号：
    CSB-YP714101RA
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    大鼠Nlrp6重组蛋白
  • 货号：
    CSB-EP714101RA
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    大鼠Nlrp6重组蛋白
  • 货号：
    CSB-EP714101RA-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    大鼠Nlrp6重组蛋白
  • 货号：
    CSB-BP714101RA
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    大鼠Nlrp6重组蛋白
  • 货号：
    CSB-MP714101RA
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Nlrp6
  • Uniprot No.：
    Q63035
  • 别名：
    Nlrp6; Nalp6; Navr; Pypaf5; NACHT; LRR and PYD domains-containing protein 6; Angiotensin II/vasopressin receptor; Non-angiotensin-vasopressin receptor; Non-AVR; PYRIN-containing APAF1-like protein 5-like
  • 种属：
    Rattus norvegicus (Rat)
  • 蛋白长度：
    Partial
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    As the sensor component of the NLRP6 inflammasome, plays a crucial role in innate immunity and inflammation. In response to yet unidentified signals, initiates the formation of the inflammasome polymeric complex, made of NLRP6, PYCARD and CASP1. Recruitment of proCASP1 to the inflammasome promotes its activation and CASP1-catalyzed IL1B and IL18 maturation and secretion in the extracellular milieu. The precise NLRP6 activation stimulus has not been identified yet. Essential for gut mucosal self-renewal and proliferation. Maintains intestinal homeostasis and a healthy intestinal microbiota. This function is, at least partially, mediated by IL18, and not IL1B, produced by nonhematopoietic cells. Influences intestinal barrier function and microbial homeostasis through the regulation of goblet cell mucus secretion. Acts by promoting autophagy in goblet cells, an essential step for mucus granule exocytosis. Its role in goblet cell physiology is inflammasome-dependent, but IL1B- and IL18-independent. During systemic bacterial infections, may negatively regulate inflammatory signaling and inhibit the influx of monocytes and neutrophils to the circulation and to the peritoneum. May promote peripheral nerve recovery following injury via an inflammasome-independent mechanism.
  • 基因功能参考文献：
    1. AVR is distinct from Nalp6/PYPAF5 based on different mRNA and protein sizes, subcellular localization, and tissue-specific expression patterns. PMID: 18413781
    2. The dual AngII/AVP receptor gene N119S/C163R variant exhibits sodium-induced dysfunction and cosegregates with salt-sensitive hypertension in the Dahl salt-sensitive hypertensive rat model. PMID: 11984003
  • 相关疾病：
    Defects in Nlrp6 may be a cause of salt-sensitive hypertension.
  • 亚细胞定位：
    [Isoform 1]: Cytoplasm. Inflammasome. Cell membrane. Nucleus membrane.; [Isoform 2]: Cytoplasm. Cell membrane. Note=Predominantly expressed at the cell membrane.
  • 蛋白家族：
    NLRP family
  • 组织特异性：
    Detected in several tissues. Expressed in renal epithelial cells in medullary thick ascending limb of Henle, as well as in salivary gland apical epithelium (at protein level). Isoform 1 is widely expressed. Isoform 2 is primarily expressed in kidney (at p
  • 数据库链接：

    KEGG: rno:171390

    STRING: 10116.ENSRNOP00000044415

    UniGene: Rn.9669

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