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  4. Recombinant Rat Myocardin (Myocd), partial

Recombinant Rat Myocardin (Myocd), partial

  • 中文名称：
    大鼠Myocd重组蛋白
  • 货号：
    CSB-YP015357RA
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    大鼠Myocd重组蛋白
  • 货号：
    CSB-EP015357RA
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    大鼠Myocd重组蛋白
  • 货号：
    CSB-EP015357RA-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    大鼠Myocd重组蛋白
  • 货号：
    CSB-BP015357RA
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    大鼠Myocd重组蛋白
  • 货号：
    CSB-MP015357RA
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Myocd
  • Uniprot No.：
    Q8R5I7
  • 别名：
    Myocd; Mycd; Myocardin
  • 种属：
    Rattus norvegicus (Rat)
  • 蛋白长度：
    Partial
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Smooth muscle cells (SM) and cardiac muscle cells-specific transcriptional factor which uses the canonical single or multiple CArG boxes DNA sequence. Acts as a cofactor of serum response factor (SRF) with the potential to modulate SRF-target genes. Plays a crucial role in cardiogenesis, urinary bladder development, and differentiation of the smooth muscle cell lineage (myogenesis).
  • 基因功能参考文献：
    1. Study demonstrates myocardin's role in upregulation of actins thru promoter regions in hepatic myofibroblasts. Myocardin-stimulated Smad2 phosphorylation and RhoA expression led to increased expression of type 1 collagen. PMID: 29035375
    2. SRF/myocardin pathway acts as a pivotal mediator of aortic vascular smooth muscle cells mechanical properties and plays a central role in the pathological aortic stiffening in hypertension. PMID: 28003268
    3. Testosterone modulates serum response factor/myocardin signaling pathway to restore the differentiated phenotype of smooth muscle cells. PMID: 27861881
    4. results suggest a novel mechanism of the transcriptional regulation of LTCC alpha1C by synergistic activities of NFATc4 and myocardin in ET-1-induced cardiomyocyte hypertrophy PMID: 27155398
    5. results demonstrated that PKCalpha inhibits myocardin-induced cardiomyocyte hypertrophy through the promotion of myocardin phosphorylation PMID: 26206583
    6. treatment of rat pulmonary artery smooth muscle cells with serum drawn from common bile duct ligation rats, resulted in a significant increase in miR-9 expression correlated with a decrease in expression of myocardin. PMID: 26147104
    7. Propose myocardin as a guardian of the contractile, noninflammatory VSMC phenotype, with loss of myocardin representing a critical permissive step in the process of phenotypic transition and inflammatory activation, at the onset of vascular disease. PMID: 25614278
    8. This study connects human cytomegalovirus IE2 to myocardin-induced transcriptional program for rat aortic smooth muscle cells survival and proliferation. PMID: 25157858
    9. These results suggest that myocardin plays a critical role in Ca(2+) signal-induced cardiomyocyte hypertrophy, which may serve as a novel mechanism that is important for cardiac hypertrophy. PMID: 25485719
    10. Cyclic stretch enhanced myocardin expression mediated by AngII through the ERK pathway in cultured rat VSMCs. PMID: 23855625
    11. the first evidence demonstrating that TEAD1 is a novel general repressor of smooth muscle-specific gene expression through interfering with myocardin binding to SRF. PMID: 24344135
    12. analysis of differences in the nuclear export mechanism between myocardin and myocardin-related transcription factor PMID: 23283978
    13. down-regulation of Yap1 promotes VSMC contractile phenotype by both up-regulating myocardin expression PMID: 22411986
    14. the transcriptional activity of myocardin in regulating cardiomyocyte hypertrophy is enhanced by co-expressing CMV IE2 PMID: 21385583
    15. The nuclear import of Mycd, MRTF-A and MRTF-B in vascular smooth muscle cell depends on importin alpha/beta1. PMID: 20847050
    16. These results are the first to show relative expression and activities of the major myocardin isoforms across disparate species. PMID: 20385216
    17. NFATc3 can promote myocardin expression, whereas miR-9 is able to suppress myocardin expression, thereby regulating cardiac hypertrophy. PMID: 20177053
    18. myocardin is an important component of a molecular switch for the SMC differentiation program PMID: 12392995
    19. findings identify myocardin as a master regulator of smooth muscle gene expression and explain how serum response factor conveys smooth muscle specificity to its target genes PMID: 12756293
    20. Ca2+ influx via L-type calcium channels stimulates expression of SMC differentiation marker genes through mechanisms that are dependent on ROK, myocardin, and increased binding of SRF to CArG cis regulatory elements. PMID: 15256479
    21. Kruppel-like factor 4 markedly repressed both myocardin-induced activation of SMC genes and expression of myocardin. PMID: 15623517
    22. identify a function for Mycd as an SRF-independent transcriptional repressor and cell-cycle regulator and provide a molecular mechanism by which interaction between RelA and Mycd plays a central role in modulating cell proliferation and differentiation PMID: 18296632
    23. Foxo3a could negatively regulate myocardin expression levels through up-regulating catalase and the consequent reduction of ROS levels PMID: 18772130
    24. Results demonstrate that CHIP-promoted proteolysis of myocardin plays a key role in the physiological control of smooth muscle cell phenotype and vessel tone. PMID: 19237536

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  • 亚细胞定位：
    Nucleus.
  • 组织特异性：
    High expression in heart, aorta media and bladder.
  • 数据库链接：

    KEGG: rno:246297

    STRING: 10116.ENSRNOP00000054372

    UniGene: Rn.163103

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