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  4. Recombinant Rat Muscleblind-like protein 2 (Mbnl2)

Recombinant Rat Muscleblind-like protein 2 (Mbnl2)

  • 中文名称：
    大鼠Mbnl2重组蛋白
  • 货号：
    CSB-YP013544RA
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    大鼠Mbnl2重组蛋白
  • 货号：
    CSB-EP013544RA
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    大鼠Mbnl2重组蛋白
  • 货号：
    CSB-EP013544RA-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    大鼠Mbnl2重组蛋白
  • 货号：
    CSB-BP013544RA
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    大鼠Mbnl2重组蛋白
  • 货号：
    CSB-MP013544RA
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Mbnl2
  • Uniprot No.：
    F2Z3T4
  • 别名：
    Mbnl2Muscleblind-like protein 2
  • 种属：
    Rattus norvegicus (Rat)
  • 蛋白长度：
    full length protein
  • 表达区域：
    1-373
  • 氨基酸序列
    MALNVAPVRD TKWLTLEVCR QYQRGTCSRS DEECKFAHPP KSCQVENGRV IACFDSLKGR CSRENCKYLH PPTHLKTQLE INGRNNLIQQ KTAAAMLAQQ MQFMFPGTPL HPVPTFPVGP TIGTNAAISF APYLAPVTPG VGLVPTEVLP TTPVIVPGSP PVTVPGSTAT QKLLRTDKLE VCREFQRGNC ARGETDCRFA HPADSTMIDT NDNTVTVCMD YIKGRCMREK CKYFHPPAHL QAKIKAAQHQ ANQAAVAAQA AAAAATVMTQ STAKALKRPL EATVDLAFPP GALHPLPKRQ ALEKSNGAST VFNPSVLHYQ QALTSAQLQQ HTAFIPTVPM MHSATSATVS AATTPATSVP FAATATANQI ILK
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Mediates pre-mRNA alternative splicing regulation. Acts either as activator or repressor of splicing on specific pre-mRNA targets. Inhibits cardiac troponin-T (TNNT2) pre-mRNA exon inclusion but induces insulin receptor (IR) pre-mRNA exon inclusion in muscle. Antagonizes the alternative splicing activity pattern of CELF proteins. RNA-binding protein that binds to 5'ACACCC-3' core sequence, termed zipcode, within the 3'UTR of ITGA3. Binds to CUG triplet repeat expansion in myotonic dystrophy muscle cells by sequestering the target RNAs. Seems to regulate expression and localization of ITGA3 by transporting it from the nucleus to cytoplasm at adhesion plaques. May play a role in myotonic dystrophy pathophysiology (DM).
  • 基因功能参考文献：
    1. Pineal Mbnl2 transcripts and protein levels exhibit marked circadian rhythms; both are neurally regulated by an adrenergic/cyclic adenosine monophosphate (cAMP) mechanism. PMID: 19457059
    2. Mbnl2 is strongly expressed in the rat pineal gland. Mbnl2 mRNA and protein exhibit a circadian rhythm with ~ sevenfold higher values at night than day levels. Mbnl2 mRNA and protein levels are controlled by an adrenergic/cAMP mechanism. PMID: 19457059
  • 亚细胞定位：
    Nucleus. Cytoplasm.
  • 蛋白家族：
    Muscleblind family
  • 组织特异性：
    Expressed in the cerebellum, pineal gland and skeletal muscle. In the pineal gland, expressed in pinealocytes, not in perivascular spaces (at protein level).
  • 数据库链接：

    KEGG: rno:680445

    STRING: 10116.ENSRNOP00000014300

    UniGene: Rn.1940

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