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  4. Recombinant Rat Multidrug resistance-associated protein 6 (Abcc6), partial

Recombinant Rat Multidrug resistance-associated protein 6 (Abcc6), partial

  • 中文名称：
    Recombinant Rat Multidrug resistance-associated protein 6(Abcc6) ,partial
  • 货号：
    CSB-YP001065RA
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    Recombinant Rat Multidrug resistance-associated protein 6(Abcc6) ,partial
  • 货号：
    CSB-EP001065RA
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    Recombinant Rat Multidrug resistance-associated protein 6(Abcc6) ,partial
  • 货号：
    CSB-EP001065RA-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    Recombinant Rat Multidrug resistance-associated protein 6(Abcc6) ,partial
  • 货号：
    CSB-BP001065RA
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    Recombinant Rat Multidrug resistance-associated protein 6(Abcc6) ,partial
  • 货号：
    CSB-MP001065RA
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Abcc6
  • Uniprot No.：
    O88269
  • 别名：
    Abcc6; Mlp1; Mrp6; Multidrug resistance-associated protein 6; ATP-binding cassette sub-family C member 6; MRP-like protein 1; MLP-1
  • 种属：
    Rattus norvegicus (Rat)
  • 蛋白长度：
    Partial
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    ATP-dependent transporter of the ATP-binding cassette (ABC) family that actively extrudes physiological compounds, and xenobiotics from cells. Mediates ATP-dependent transport of glutathione conjugates such as leukotriene-c4 (LTC4) and N-ethylmaleimide S-glutathione (NEM-GS) (in vitro). Transports also an anionic cyclopentapeptide endothelin antagonist, BQ-123.; Mediates the release of nucleoside triphosphates, predominantly ATP, into the circulation, where it is rapidly converted into AMP and the mineralization inhibitor inorganic pyrophosphate (PPi) by the ecto-enzyme ectonucleotide pyrophosphatase phosphodiesterase 1 (ENPP1), therefore playing a role in PPi homeostasis.
  • 基因功能参考文献：
    1. This study suggests a critical role of hepatic ABCC6 in contributing to plasma inorganic pyrophosphate levels, identifying liver as a target of molecular correction to counteract ectopic mineralization in pseudoxanthoma elasticum PMID: 28111129
    2. In a rat model of CKD, ABCC6 protein expression was decreased in liver and kidney, however mRNA levels were unchanged. PMID: 24994603
    3. In the absence of transfected rat ABCC6, HeLa and HEK293 cells released almost no ATP, but on induction of rat ABCC6, they released substantial amounts of ATP into the cell culture medium. PMID: 24969777
  • 亚细胞定位：
    Basolateral cell membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein. Lateral cell membrane; Multi-pass membrane protein.
  • 蛋白家族：
    ABC transporter superfamily, ABCC family, Conjugate transporter (TC 3.A.1.208) subfamily
  • 组织特异性：
    Predominantly expressed in the liver and to a lesser extent in kidney, small intestine, and colon.
  • 数据库链接：

    KEGG: rno:81642

    STRING: 10116.ENSRNOP00000051412

    UniGene: Rn.29976

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