Recombinant Rat Mineralocorticoid receptor (Nr3c2), partial

1. We propose that, in the spontaneously hypertensive rat hippocampus, increased MR expression causes a bias towards a pro-inflammatory phenotype characteristic for hypertensive encephalopathy. PMID: 28523794
2. MR signaling does not play a role in ERK and CREB phosphorylation nor in tyrosine hydroxylase expression in the nucleus of tractus solitaries. PMID: 26598419
3. A NeuroD family member (NeuroD2) binding to an additional motif near the Glucocorticoid receptor response element seems to drive specificity for Mineralocorticoid receptor over glucocorticoid receptor binding at hippocampal binding sites. PMID: 28324065
4. The scaffolding protein RACK1 is associated with mineralocorticoid receptor (MR) under basal and agonist-stimulated conditions and facilitates agonist-stimulated MR actions through PKC-beta. These findings indicate that RACK1 is a newly described coactivator of MR. PMID: 28472300
5. MR-immunoreactivity and 11beta-Hydroxysteroid dehydrogenase 2-in situ hybridised products are colocalised in magnocellular neurosecretory cells. PMID: 26403275
6. The discovered changes in the expression level of catechol-o-methyltransferase , mineralocorticoid receptor , and b-subunit of epithelial sodium channel confirm their involvement in increased sympathetic stimulation of the of hypertensive rats PMID: 27215035
7. Findings indicate that CS-3150 is a selective and highly potent mineralocorticoid receptor antagonist with long-lasting oral activity. PMID: 26073023
8. Data suggest that mixed mineralocorticoid (MRs) and glucocorticoid receptors (GRs) such as C118335, can be used to unravel the mechanisms of glucocorticoid signaling. PMID: 26305887
9. Spironolactone dose dependently inhibits the progression of vascular calcification by suppressing MR signaling, local inflammation, osteogenic transition, and apoptosis in the aortas of CKD rats. PMID: 26336165
10. These findings indicate that GEMIN4 functions as a novel coregulator of the MR. PMID: 25555524
11. Data indicate that 10-6 M spironolactone fully inhibited the mineralocorticoid receptor (MR) transactivation induced by 10-8 M aldosterone while torasemide has only a weak inhibitory effect. PMID: 24040049
12. the PAK1-MR pathway plays a role in cardiac inflammation and remodeling induced by large BPV superimposed on hypertension, independent of circulating aldosterone. PMID: 23470864
13. Exposure to enriched environment restores cognitive impairments induced by chronic cerebral hypoperfusion and up-regulates mineralocorticoid- and glucocorticoid-receptor expression. PMID: 23290935
14. Mineralocorticoid receptors/epithelial Na(+) channels in the choroid plexus are involved in hypertensive mechanisms in stroke-prone spontaneously hypertensive rats. PMID: 23096235
15. These results suggest that MR expression and activation in iris/ciliary body could protect the ocular structures against damages induced by endotoxin-induced uveitis. PMID: 23152847
16. These results suggest that oxidative stress plays an important role in glomerular MR activation in Dahl salt-sensitive rats. PMID: 22911865
17. MR expression is increased in the hippocampus and hypothalamus of SHR. PMID: 22564091
18. Hydrocortisone upregulated TTR expression in choroid plexus, an effect suppressed by glucocorticoid receptor and mineralocorticoid receptor antagonists. PMID: 22371232
19. These results suggest that immobilization and immobilization with chewing differentially affect these two types of glucocorticoid receptors in the rat hippocampus. PMID: 22579827
20. MR antagonism improves proximal tubule integrity by targeting mTOR/S6K1 signaling and redox status independent of changes in blood pressu PMID: 22205374
21. MRbeta transcript has a novel key role in response to injury that suggests that some of the known neuroprotective effects of hypothermia may be mediated through increased MR expression. PMID: 19433261
22. MR has important roles in atrial structural remodeling and atrial fibrillation inducibility in Dahl rats. PMID: 21248754
23. Hormones elevated in hypertension, i.e., aldosterone and angiotensin II, which exert genotoxic effects in vitro, could contribute to carcinogenesis in hypertension via MCR PMID: 21135038
24. Differential regulation of MR and GR may alter the level of heterodimerization of the receptors and hence may contribute to the complexity of corticosteroid effects on aldosterone-sensitive distal nephron function PMID: 20861076
25. Mineralocorticoid receptor activation contributes to salt-induced hypertension and renal injury in prepubertal Dahl salt-sensitive rats. PMID: 20466668
26. These results suggest additional mechanisms for diabetes-induced functional alterations and support a restorative role for dentate gyrus mineralocorticoid receptors. PMID: 20196138
27. Increased MR signaling may promote and amplify age-associated inflammation accompanying arterial aging through increased angiotensin II-stimulated MR expression and ssensitivity to aldosterone-mediated extracellular signal-regulated kinase 1/2 activation. PMID: 20421514
28. The aldosterone/mineralocorticoid receptor system associates with the p300/GATA4 transcriptional pathway during the hypertrophic response of cardiomyocytes. PMID: 19966502
29. GR and MR mediated-mechanisms induce anxiety and visceral hypersensitivity, whereas somatic sensitivity involves only GR, suggesting that corticosteroids may enhance visceral and somatic sensation via divergent processes originating in the amygdala PMID: 19875699
30. Data suggest that decreased mineralocorticoid receptor (MR), possibly epigenetically mediated, is a novel mechanism by which phthalates may affect diverse functions later in life. PMID: 19819939
31. results support the prospect that mineralocorticoid receptor as well as glucocorticoid receptor can participate in the transduction of phasic corticosteroid signals PMID: 12399411
32. Findings suggest that activation of MR in the central nervous system plays a critical role in regulating TNF-alpha release in heart failure rats PMID: 12529282
33. lower levels of MR, but not GR, contribute to the increased HPA activity in the obese Zucker rats and that this seems more influential during stress than in the basal state. PMID: 12810555
34. In situ hybridization analysis revealed increased hippocampal mineralocorticoid receptor messenger RNA density (p <.05) in daily handling-maternal separation for 15 minutes (HMS15)versus HMS180 animals. PMID: 14960289
35. cross-talk between the nongenomic and genomic responses to aldosterone in renal cells and suggest that the aldosterone-MR mediated increase in mRNA/protein synthesis and ion transport depends upon PKCalpha activation PMID: 15100355
36. different activity/reactivity of the mineralocorticoid signaling pathway between the two rat strains, Brown Norway and Fischer 344 is a tyrosine to cysteine substitution (Y73C) in the N-terminal part of the Brown Norway mineralocorticoid receptor. PMID: 15252022
37. enhanced sensitivity of the spontaneously hypertensive rat to glucocorticoids and aldosterone may be in part associated with enhanced glucocorticoid and mineralocorticoid receptor densities in the microcirculation PMID: 15280098
38. Besides fibrinogenesis, MR activation has a crucial role in electrical remodeling early after myocardial insult and before morphological remodeling. PMID: 15289366
39. Aldosterone directly induces mesangial cell proliferation and deformability through mineralocorticoid receptors and ERK1/2 activation, which may contribute to the pathogenesis of glomerular mesangial injury. PMID: 15699469
40. Glucocorticoid receptors can act directly to induce hippocampal neuronal death and that demonstration of their full apoptotic potency depends on abolition of survival-promoting actions mediated by mineralocorticoid recetors. PMID: 15940303
41. aldosterone seems to exert mainly MR-induced effects that stimulate c-Raf, MEK1/2, MAPK1/2, the activities of CDK2 and CDK4, and the cell-cycle progression in mesangial cells PMID: 15975997
42. Hippocampal expression of the mineralocorticoid (MR) and glucocorticoid (GR) receptors differed. Low-anxiety rats displayed higher hippocampal expression of MR but not GR than high-anxiety rats. Levels of anxiety quantified a trait rather than a state. PMID: 16580234
43. Mineralocorticoid receptor blockade but not steroid withdrawal reverses renal fibrosis in deoxycorticosterone/salt rats PMID: 16627578
44. Input from the hippocampus to the PVN has distinct and differential inhibitory effects on the expression of MR mRNA that may operate independently from the feedback actions of corticosterone. PMID: 17244200
45. postulate that there are at least two possible mechanisms for MCR nuclear translocation. One of them is hsp90- and NL1-dependent, and the other functions in a manner that is independent of the classical pathway. PMID: 17260968
46. Glucocorticoid and mineralocorticoid receptors play critical roles in cortisol induced anxiety and colonic hypersensitivity. PMID: 17347454
47. The mesangial cell mineralocorticoid receptor interacts with a putative aldosterone-response element of the osteopontin promoter. PMID: 17546625
48. These studies highlight an apparent sexual dimorphism of MR expression and activity in the cerebral vasculature from hypertensive rats PMID: 17670862
49. Blockade of aldosterone receptor was sufficient to prevent proteinuria commonly associated with hypertension, suggesting that aldosterone does contribute to renal damage in Cyp1a1-Ren2 hypertensive rats. PMID: 17715265
50. Obtaining adult knockdown rats with defects in hormone and electrolyte homeostasis resembling pseudohypoaldosteronism. PMID: 18337591

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KEGG: rno:25672

STRING: 10116.ENSRNOP00000045942

UniGene: Rn.9678