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  4. Recombinant Rat Metabotropic glutamate receptor 4 (Grm4), partial

Recombinant Rat Metabotropic glutamate receptor 4 (Grm4), partial

  • 中文名称：
    大鼠Grm4重组蛋白
  • 货号：
    CSB-YP009934RA
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    大鼠Grm4重组蛋白
  • 货号：
    CSB-EP009934RA
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    大鼠Grm4重组蛋白
  • 货号：
    CSB-EP009934RA-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    大鼠Grm4重组蛋白
  • 货号：
    CSB-BP009934RA
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    大鼠Grm4重组蛋白
  • 货号：
    CSB-MP009934RA
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Grm4
  • Uniprot No.：
    P31423
  • 别名：
    Grm4; Gprc1d; Mglur4Metabotropic glutamate receptor 4; mGluR4
  • 种属：
    Rattus norvegicus (Rat)
  • 蛋白长度：
    Partial
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    G-protein coupled receptor for glutamate. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors. Signaling inhibits adenylate cyclase activity.
  • 基因功能参考文献：
    1. This study investigated the role of mGluR4 in modulating two distinct forms of waiting impulsivity and its putative interaction with D2 receptors in modulating motor impulsivity on the five-choice serial reaction time task. The main findings indicate a prominent role of mGluR4 in modulating motor, and to some extent choice, impulsivity as well as aspects of visual attention. PMID: 28487067
    2. activation of mGluR4 prevents oxidative stress-induced NSC death and apoptotic-associated protein activities with involvement of inhibiting the JNK and p38 pathways in cell culture. PMID: 26176363
    3. mGluR4 promotes the proliferation of rat neural progenitor cells and cyclin D1 expression through activation of ERK1/2 signaling pathways in vitro. PMID: 23374450
    4. mGluR4 inhibition of presynaptic Ca2+ influx employs a newly defined signalling pathway, notably that involving the activation of phospholipase C and ultimately protein kinase C PMID: 22570379
    5. native mGluR4 interacts with several exocytosis proteins such as Munc18-1, synapsins, and syntaxin. PMID: 22528491
    6. Selective activation of mGluR4 with L(+)-2-amino-4-phosphnobytyric acid decreased the probability of glutamate release from the mossy fiber terminals synapsing onto stratum lacunosum-moleculare interneurons. PMID: 20824730
    7. these results suggest the alteration of the spinal mGluR4 expression that contributes to the development of neuropathic pain. PMID: 21358553
    8. The increased expression of mGluR4 is an important process in the pathophysiological of DBI and its specific agonist L-AP4 can provide a remarkable neuroprotection against DBI but also in the motor and cognitive performance. PMID: 14592619
    9. mGluR4 is potentiated by N-phenyl-7-(hydroxylimino)cyclopropa[b]chromen-1a-carboxamide (PHCCC) PMID: 14593202
    10. results indicate that alpha- and F cells express functional mGluR4, and its stimulation inhibits secretion of glucagon through an inhibitory cAMP cascade PMID: 15047615
    11. Retinal terminals are the major contributors to the mGluR4a immunoreactivity observed in the superior collicular circuitry. PMID: 15730868
    12. Striatonigral/striato-entopeduncular MSNs are likely to be the largest source of type 2 mGluR4-immunopositive axon terminals in the neostriatum. All ChAT-immunopositive and 41% of NK1 receptor-positive dendrites were heavily associated with type 2 mGluR4. PMID: 17177262
    13. PHCCC is an allosteric modulator of mGlu(4) receptor, without direct agonist activity. PMID: 18593581

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  • 亚细胞定位：
    Cell membrane; Multi-pass membrane protein.
  • 蛋白家族：
    G-protein coupled receptor 3 family
  • 组织特异性：
    Is widely distributed in the CNS. Predominant expression is seen in the granule cells of the cerebellum.
  • 数据库链接：

    KEGG: rno:24417

    STRING: 10116.ENSRNOP00000060812

    UniGene: Rn.89046

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