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  4. Recombinant Rat Membrane-associated progesterone receptor component 1 (Pgrmc1), partial

Recombinant Rat Membrane-associated progesterone receptor component 1 (Pgrmc1), partial

  • 中文名称：
    大鼠Pgrmc1重组蛋白
  • 货号：
    CSB-YP017876RA1
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    大鼠Pgrmc1重组蛋白
  • 货号：
    CSB-EP017876RA1
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    大鼠Pgrmc1重组蛋白
  • 货号：
    CSB-EP017876RA1-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    大鼠Pgrmc1重组蛋白
  • 货号：
    CSB-BP017876RA1
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    大鼠Pgrmc1重组蛋白
  • 货号：
    CSB-MP017876RA1
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Pgrmc1
  • Uniprot No.：
    P70580
  • 别名：
    Pgrmc1; 25dx; Lewi; Pgrmc; Membrane-associated progesterone receptor component 1; mPR; 25-DX; Acidic 25 kDa protein; Ventral midline antigen; VEMA
  • 种属：
    Rattus norvegicus (Rat)
  • 蛋白长度：
    Partial
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

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Pgrmc1 Proteins

靶点详情

  • 功能：
    Component of a progesterone-binding protein complex. Binds progesterone. Has many reported cellular functions (heme homeostasis, interaction with CYPs). Required for the maintenance of uterine histoarchitecture and normal female reproductive lifespan. Intracellular heme chaperone. Regulates heme synthesis via interactions with FECH and acts as a heme donor for at least some hemoproteins. May be implicated in 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) immunotoxicity.
  • 基因功能参考文献：
    1. The PGRMC1 expression level correlates with the binding activity of SW120 in rat brain cells. PMID: 26335282
    2. PGRMC1 and PGRMC2 are involved in regulating entry into the G1 stage of the cell cycle. PMID: 25253729
    3. Knockdown by siRNA-Pgrmc1 in microglia before add-back to astrocyte-neuron cocultures suppressed the P4-E2 antagonism of neurite outgrowth PMID: 23653459
    4. After brain injury, mPRalpha expression was induced in oligodendrocytes, astrocytes and reactive microglia. This points to a role in mediating modulatory effects of progesterone in inflammation, ion and water homeostasis and myelin repair in the injured brain PMID: 23211561
    5. The ability to suppress Tcf/Lef activity is part of the mechanism through which P4 activation of PGRMC1 regulates the gene cascades that control granulosa cell function with this action being dependent in part on the sumoylation status of PGRMC1. PMID: 22719051
    6. Pgrmc1 and Pgrmc2 may play roles in neuroendocrine and reproductive functions of the female rat. PMID: 20977928
    7. PGRMC1 protein complex identified as the putative sigma-2 receptor binding site. PMID: 21730960
    8. roles of progesterone (P4) and Progesterone Receptor Membrane Component 1 (PGRMC1) in regulating mitosis of spontaneously immortalized granulosa cells (SIGCs). P4's actions appear to be dependent on PGRMC1's function within the mitotic spindle. PMID: 21148105
    9. The present studies suggest a genomic component to PGRMC1's anti-apoptotic mechanism of action, which requires the presence of the PGRMC1 dimer. PMID: 20144686
    10. Membrane-bound progesterone receptor (mPR) is a mediator of physiologic effects of the sex hormones. PMID: 15570619
    11. Expression of 25-Dx in structures involved in CSF production and in osmoregulation, and its up-regulation after brain damage, point to role of this progesterone-binding protein in maintenance of water homeostasis after traumatic brain injury. PMID: 15934950
    12. Molecular identification of 25-Dx had it as a heme-binding protein. PMID: 16279947
    13. PGRMC1 is the progesterone binding protein that mediates P4's antiapoptotic action PMID: 17991724

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  • 亚细胞定位：
    Microsome membrane; Single-pass membrane protein. Smooth endoplasmic reticulum membrane; Single-pass membrane protein. Mitochondrion outer membrane; Single-pass membrane protein; Extracellular side.
  • 蛋白家族：
    Cytochrome b5 family, MAPR subfamily
  • 组织特异性：
    Expressed at high levels in lung, liver, kidney and brain, low in testis and spleen. Not expressed in heart and skeletal muscle.
  • 数据库链接：

    KEGG: rno:291948

    STRING: 10116.ENSRNOP00000017101

    UniGene: Rn.102356

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