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  4. Recombinant Rat Long-chain-fatty-acid--CoA ligase 1 (Acsl1), partial

Recombinant Rat Long-chain-fatty-acid--CoA ligase 1 (Acsl1), partial

  • 中文名称：
    Recombinant Rat Long-chain-fatty-acid--CoA ligase 1(Acsl1),partial
  • 货号：
    CSB-YP001191RA1
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    Recombinant Rat Long-chain-fatty-acid--CoA ligase 1(Acsl1),partial
  • 货号：
    CSB-EP001191RA1
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    Recombinant Rat Long-chain-fatty-acid--CoA ligase 1(Acsl1),partial
  • 货号：
    CSB-EP001191RA1-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    Recombinant Rat Long-chain-fatty-acid--CoA ligase 1(Acsl1),partial
  • 货号：
    CSB-BP001191RA1
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    Recombinant Rat Long-chain-fatty-acid--CoA ligase 1(Acsl1),partial
  • 货号：
    CSB-MP001191RA1
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Acsl1
  • Uniprot No.：
    P18163
  • 别名：
    Acsl1; Acs1; Acsl2; Facl2; Long-chain-fatty-acid--CoA ligase 1; Arachidonate--CoA ligase; Long-chain acyl-CoA synthetase 1; LACS 1; Long-chain-fatty-acid--CoA ligase, liver isozyme; Phytanate--CoA ligase
  • 种属：
    Rattus norvegicus (Rat)
  • 蛋白长度：
    Partial
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

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Acsl1 Proteins

靶点详情

  • 功能：
    Catalyzes the conversion of long-chain fatty acids to their active form acyl-CoAs for both synthesis of cellular lipids, and degradation via beta-oxidation. Preferentially uses palmitoleate, oleate and linoleate. Preferentially activates arachidonate than epoxyeicosatrienoic acids (EETs) or hydroxyeicosatrienoic acids (HETEs).
  • 基因功能参考文献：
    1. here we revealed that ACSs (Faa1 and Faa4 in yeast and ACSL1, ACSL4, ACSL5, ACSL6, and ACSVL4 in mammals) are involved in LCB uptake. In addition, we provided important insight into the molecular mechanism of LCFA transport PMID: 27136724
    2. Acyl-CoA synthetase 1 deficiency alters cardiolipin species and impairs mitochondrial function PMID: 26136511
    3. Acsl isozymes play distinct roles in the control of AA remodeling in rat fibroblasts: Acsl4 acts as the first step of enzyme for AA remodeling following IL-1beta stimulation, and Acsl1 is involved in the maintenance of some AA-containing PC species. PMID: 24095834
    4. The fatty metabolism is stimulated in the CNS during a chronic pain state. PMID: 14622223
    5. Acyl-CoA synthetase 2 has a role in fatty acid internalization and neurite outgrowth PMID: 15051725
    6. Long-chain acyl-CoenzymeA synthetase-2 expression is significantly upregulated in distinct regions of the frontal cortex in learned helpless rats relative to controls PMID: 15093965
    7. rat long chain acyl-coa synthetase 1 has a role in fatty acid metabolism in rat primary hepatocytes PMID: 17028193

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  • 亚细胞定位：
    Mitochondrion outer membrane; Single-pass type III membrane protein. Peroxisome membrane; Single-pass type III membrane protein. Microsome membrane; Single-pass type III membrane protein. Endoplasmic reticulum membrane; Single-pass type III membrane protein.
  • 蛋白家族：
    ATP-dependent AMP-binding enzyme family
  • 组织特异性：
    Liver, heart, epididymal adipose and to a lesser extent brain, small intestine and lung.
  • 数据库链接：

    KEGG: rno:25288

    STRING: 10116.ENSRNOP00000014235

    UniGene: Rn.6215

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