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  4. Recombinant Rat Keratin, type II cytoskeletal 8 (Krt8)

Recombinant Rat Keratin, type II cytoskeletal 8 (Krt8)

  • 中文名称：
    大鼠Krt8重组蛋白
  • 货号：
    CSB-YP607438RA
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    大鼠Krt8重组蛋白
  • 货号：
    CSB-EP607438RA
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    大鼠Krt8重组蛋白
  • 货号：
    CSB-EP607438RA-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    大鼠Krt8重组蛋白
  • 货号：
    CSB-BP607438RA
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    大鼠Krt8重组蛋白
  • 货号：
    CSB-MP607438RA
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Krt8
  • Uniprot No.：
    Q10758
  • 别名：
    Krt8; Krt2-8; Keratin; type II cytoskeletal 8; Cytokeratin endo A; Cytokeratin-8; CK-8; Keratin-8; K8; Type-II keratin Kb8
  • 种属：
    Rattus norvegicus (Rat)
  • 蛋白长度：
    full length protein
  • 表达区域：
    1-483
  • 氨基酸序列
    MSVRVTQKSY KMSTSGPRAF SSRSFTSGPG ARISSSSFSR VGSSSSSFRG SLGGFGGAGV GGITAVTVNQ SLLNPLKLEV DPNIQAVRTQ EKEQIKTLNN KFASFIDKVR FLEQQNKMLE TKWSLLQQQK TSRSNMDNMF ESYINNLRRQ LEALGQEKLK LEVELGNMQG LVEDFKNKYE DEINKRTEME NEFVLIKKDV DEAYMNKVEL ESRLEGLTDE INFLRQIHEE EIRELQSQIS DTSVVLSMDN SRSLDMDSII AEVRAQYEEI ANRSRAEAET MYQIKYEELQ TLAGKHGDDL RRSKTEISEM NRNISRLQAE IDALKGQRAT LEAAIADAEQ RGELAVKDAN AKLEDLKNAL QKAKQDMARQ LREYQELMNV KLALDIEIAT YRKLLEGEES RLESGMQNMS IHTKTTSGYA GGLSSSYGGL TSPGFSYGMS SFQPGFGSVG GSSTYSRTKA VVVKKIETRD GKLVSESSDI MSK
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Together with KRT19, helps to link the contractile apparatus to dystrophin at the costameres of striated muscle.
  • 基因功能参考文献：
    1. Results indicate a keratins K8/K18 intermediate filament (IF) contribution to the cell stiffness-extracellular matrix (ECM) interplay through a modulation of Rho-dependent actin organization. PMID: 22685604
    2. cytokeratins 8 and 19 are expressed in adult striated muscle, where they may contribute to the organization of both the myoplasm and sarcolemma PMID: 15247274
    3. shear stress mediates the phosphorylation of serine residues in K8, leading to the disassembly of intermediate filaments in alveolar epithelial cells PMID: 15972820
    4. data imply that CK8/18 overexpression, those cytokeratins complex formation associated w/ histone type 2 H2aa3 upregulation & intermediate filament reorganization may drive neoplastic transformation of GST-P positive foci during rat hepatocarcinogenesis PMID: 19409407
  • 亚细胞定位：
    Cytoplasm. Nucleus, nucleoplasm. Nucleus matrix.
  • 蛋白家族：
    Intermediate filament family
  • 组织特异性：
    Expressed in cardiac and striated muscle. Expressed at Z-lines within the muscle fibers and at Z-line and M-line domains at costameres at the sarcolemmal membrane (at protein level). Observed in coagulating gland, bladder, salivary gland, kidney, spleen,
  • 数据库链接：

    KEGG: rno:25626

    STRING: 10116.ENSRNOP00000029068

    UniGene: Rn.11083

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