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  4. Recombinant Rat Integrin alpha-1 (Itga1), partial

Recombinant Rat Integrin alpha-1 (Itga1), partial

  • 中文名称：
    大鼠Itga1重组蛋白
  • 货号：
    CSB-YP011861RA
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    大鼠Itga1重组蛋白
  • 货号：
    CSB-EP011861RA
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    大鼠Itga1重组蛋白
  • 货号：
    CSB-EP011861RA-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    大鼠Itga1重组蛋白
  • 货号：
    CSB-BP011861RA
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    大鼠Itga1重组蛋白
  • 货号：
    CSB-MP011861RA
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Itga1
  • Uniprot No.：
    P18614
  • 别名：
    Itga1Integrin alpha-1; CD49 antigen-like family member A; Laminin and collagen receptor; VLA-1; CD antigen CD49a
  • 种属：
    Rattus norvegicus (Rat)
  • 蛋白长度：
    Partial
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Integrin alpha-1/beta-1 is a receptor for laminin and collagen. It recognizes the proline-hydroxylated sequence G-F-P-G-E-R in collagen. Involved in anchorage-dependent, negative regulation of EGF-stimulated cell growth.
  • 基因功能参考文献：
    1. periodic mechanical stress induced ECM expression and the migration of NP cells via upregulating the expression of integrin alpha1 and the phosphorylation of downstream PLCgamma1. These findings provide novel information to aid the understanding of the pathogenesis and development of IDD. PMID: 27484337
    2. This study shows that E2 protects against apoptosis in a time-dependent manner, and alpha1 integrin-mediated adhesion to collagen II is essential for estrogen-dependent anti-apoptosis in rat annulus fibrosus cells in vitro. PMID: 27108411
    3. Alpha1beta1 and integrin-linked kinase interact and modulate angiotensin II effects on vascular smooth muscle cell proliferation/migration. PMID: 26520903
    4. Dynamic structural changes are observed upon collagen and metal ion binding to the integrin alpha1 I domain. PMID: 22847004
    5. Data suggest that endothelin-1 promotes collagen matrix reorganization through the enhancement of mesangial cell alpha1beta1 integrin-dependent migration and MMP-2 activity. PMID: 12459174
    6. Pretreatment of mature hippocampal neurons with either echistatin or alpha(1) integrin-blocking antibodies prevented beta-amyloid-induced MAPK activation. The blockage of alpha(1) activation prevented cell death induced by beta-amyloid. PMID: 14991844
    7. After spinal cord contusion, the area of alpha1beta1 integrin positive blood vessels increases within 11 mm from the injury site at 3 days post-injury and remains prominent within the injured core only at 7 days. PMID: 17161391
    8. Alpha(1)beta(1)-integrin has a key role in flow (shear stress)-dependent vasodilation in resistance arteries by transmitting the signal to eNOS through activation of PI3-kinase and Akt. PMID: 18245559

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  • 亚细胞定位：
    Membrane; Single-pass type I membrane protein.
  • 蛋白家族：
    Integrin alpha chain family
  • 数据库链接：

    KEGG: rno:25118

    STRING: 10116.ENSRNOP00000016353

    UniGene: Rn.91044

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