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  4. Recombinant Rat Inositol 1,4,5-trisphosphate receptor type 3 (Itpr3), partial

Recombinant Rat Inositol 1,4,5-trisphosphate receptor type 3 (Itpr3), partial

  • 中文名称：
    大鼠Itpr3重组蛋白
  • 货号：
    CSB-YP730887RA
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    大鼠Itpr3重组蛋白
  • 货号：
    CSB-EP730887RA
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    大鼠Itpr3重组蛋白
  • 货号：
    CSB-EP730887RA-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    大鼠Itpr3重组蛋白
  • 货号：
    CSB-BP730887RA
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    大鼠Itpr3重组蛋白
  • 货号：
    CSB-MP730887RA
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Itpr3
  • Uniprot No.：
    Q63269
  • 别名：
    Itpr3; Inositol 1,4,5-trisphosphate receptor type 3; IP3 receptor isoform 3; IP3R 3; InsP3R3; Type 3 inositol 1,4,5-trisphosphate receptor; Type 3 InsP3 receptor
  • 种属：
    Rattus norvegicus (Rat)
  • 蛋白长度：
    Partial
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Receptor for inositol 1,4,5-trisphosphate, a second messenger that mediates the release of intracellular calcium.
  • 基因功能参考文献：
    1. An age-related decline in IP3R3 expression and NPY signaling underlie age-related homeostatic changes and olfactory dysfunction. PMID: 25482245
    2. It regulates calcium transients in neonatal rat ventricular myocytes.(37-46) PMID: 25242084
    3. Physiologically relevant reactive oxygen species controls cytoplasmic and mitochondrial calcium transport through IP3R3. PMID: 24469450
    4. A phosphomimetic mutation at T-930 of the rat Ins(1,4,5)P 3 receptor results in decreased Ins(1,4,5)P 3-dependent Ca ( 2+) release and lowers the Ins(1,4,5)P 3 binding affinity of the receptor. PMID: 22878752
    5. Cyclic AMP-induced ductular bicarbonate secretion depends on an autocrine signaling pathway that involves CFTR, apical release of ATP, stimulation of apical nucleotide receptors, and then activation of apical, type III InsP3Rs. PMID: 17916355
    6. After apoptosis induction calcium permeability of the nuclear calcium store vesicles increases via IP(3) receptor translocation to nucleus. PMID: 21302308
    7. Sulfhydryl redox modification can regulate various aspects of intracellular Ca2+ signaling, including quantal Ca2+ release, by tuning ligand sensitivities of InsP3R channels. PMID: 20643058
    8. findings show that repeated exposure to amphetamine causes sensitization of IP3 receptors in ventral tegmental area dopamine neurons, resulting in an enhancement of mGluR-dependent NMDA receptor LTP PMID: 20463231
    9. regulation of type 3 inositol trisphosphate receptors by cytosolic calcium PMID: 11875073
    10. the injurious effects of Ca2+i in traumatic central nervous system (CNS) white matter injury appear to be mediated both by RyRs and through IP3Rs calcium-induced calcium release receptors (CICRs) PMID: 11939501
    11. analysis of binding affinity of inositol 1,4,5-trisphosphate (IP(3)) receptors from cerebellum to adenophostin A PMID: 12088506
    12. Expression of the rat type-3 IP3R in IP3R-KO chicken cells rescued agonist-dependent intracellular Ca2+ release & Ba2+ influx. PMID: 12198155
    13. inositol 1,4,5-trisphosphate (IP(3)) receptor is selectively phosphorylated by cGMP-dependent protein kinase in intact smooth muscle resulting in inhibition of IP(3)-dependent Ca(2+) release PMID: 12529267
    14. in taste buds, a large subset of type II cells and a small subset of type III cells display IP(3)R3 immunoreactivity within their cytoplasm PMID: 14681927
    15. IP3-dependent conformational change in the IP3R, not endoplasmic reticulum Ca2+ pool release, triggers agonist induced CA2+ entry. PMID: 14983008
    16. Overexpression of RACK1 or depletion of RACK1 by interference RNA markedly augments or diminishes Ca2+ release. PMID: 14983009
    17. strong evidence that IP3Rs are required for BCR (B-cell receptor)-mediated Ca2+ entry in DT40 cells PMID: 15175012
    18. Data show that phosphorylation of 1,4,5-trisphosphate receptor (IP(3)R)1 by protein kinase C was about eight times stronger than that of IP(3)R3 under identical conditions. PMID: 15184066
    19. The 3 phosphorylation sites of IP3R, all of shich are located close to a putative surface-exposed peptide loop, are described. PMID: 16107208
    20. the finding that interactions between protein 4.1N and the 1,4,5-trisphosphate receptor vary among cell types may provide an additional, tissue-specific mechanism to shape the pattern of Ca2+ waves. PMID: 16122796
    21. Data show that IP3R3-mediated Ca2+ mobilization is unaffected by phosphorylation of S916, S934, and S1832, and suggest that modification of Ca2+ flux may not be the primary effect of IP3R3 phosphorylation by PKA. PMID: 17257671
    22. These results suggest the existence of a negative feedback mechanism involving two components of the Ca2+ signalling cascade, whereby activated PKC dampens IP3R-3 activity. PMID: 17320950
    23. Transient upregulation of postsynaptic IP3 receptor-gated calcium signaling constitutes a novel form of short-term synaptic plasticity. PMID: 18434513
    24. the mechanism responsible for augmenting InsP(3)R-1 channel activity following phosphorylation PMID: 18535093
    25. findings show that changes in cellular oxidation/reduction balance during hypoxia increase cytosolic NAD(P)H, and that this triggers the release of Ca2+ from the endoplasmic reticulum via activation of IP3 receptors PMID: 19217932
    26. we determined the interaction between zonisamide and inositol-1,4,5-triphosphate receptor (IP3R) on exocytosis of neurotransmitters in rat frontal cortex. PMID: 19429061

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  • 亚细胞定位：
    Endoplasmic reticulum membrane; Multi-pass membrane protein.
  • 蛋白家族：
    InsP3 receptor family
  • 数据库链接：

    KEGG: rno:25679

    STRING: 10116.ENSRNOP00000011516

    UniGene: Rn.11242

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