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  4. Recombinant Rat Hypoxia up-regulated protein 1 (Hyou1), partial

Recombinant Rat Hypoxia up-regulated protein 1 (Hyou1), partial

  • 中文名称：
    大鼠Hyou1重组蛋白
  • 货号：
    CSB-YP723594RA
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    大鼠Hyou1重组蛋白
  • 货号：
    CSB-EP723594RA
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    大鼠Hyou1重组蛋白
  • 货号：
    CSB-EP723594RA-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    大鼠Hyou1重组蛋白
  • 货号：
    CSB-BP723594RA
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    大鼠Hyou1重组蛋白
  • 货号：
    CSB-MP723594RA
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Hyou1
  • Uniprot No.：
    Q63617
  • 别名：
    Hyou1; Orp150; Hypoxia up-regulated protein 1; 150 kDa oxygen-regulated protein; ORP-150
  • 种属：
    Rattus norvegicus (Rat)
  • 蛋白长度：
    Partial
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Has a pivotal role in cytoprotective cellular mechanisms triggered by oxygen deprivation. May play a role as a molecular chaperone and participate in protein folding.
  • 基因功能参考文献：
    1. Data reveal that Grp170 participates in preparing mutant proinsulin for degradation while enabling wild-type proinsulin escape from the endoplasmic reticulum. PMID: 28028074
    2. Results imply a probable role of ORP150 in the changes in appearance and function of pancreatic beta cells following acute necrotizing pancreatitis, through the pathway of endoplasmic reticulum stress. PMID: 21536389
    3. role for the protein both in preventing cardiomyocyte death and in preserving contractile function after ischemic damage PMID: 15733911
    4. ER stress proteins (GRP78 and ORP150), respectively) were upregulated at PTCs in experimental proteinuric rats. PMID: 16955111
    5. These data reveal a novel cellular localization for ORP150 and that mitochondrial ORP150 is upregulated by CHOP/GADD153 in response to mitochondrial and ER stress. Our data also reveal that ORP150 is a substrate for mitochondrial calpain 10. PMID: 18094145

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  • 亚细胞定位：
    Endoplasmic reticulum lumen.
  • 蛋白家族：
    Heat shock protein 70 family
  • 组织特异性：
    Selectively expressed by cultured astrocytes but not endothelial cells, microglia or neurons.
  • 数据库链接：

    KEGG: rno:192235

    STRING: 10116.ENSRNOP00000039172

    UniGene: Rn.10542

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