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  4. Recombinant Rat Homeobox protein Nkx-2.5 (Nkx2-5)

Recombinant Rat Homeobox protein Nkx-2.5 (Nkx2-5)

  • 中文名称：
    大鼠Nkx2-5重组蛋白
  • 货号：
    CSB-YP015845RA
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    大鼠Nkx2-5重组蛋白
  • 货号：
    CSB-EP015845RA
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    大鼠Nkx2-5重组蛋白
  • 货号：
    CSB-EP015845RA-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    大鼠Nkx2-5重组蛋白
  • 货号：
    CSB-BP015845RA
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    大鼠Nkx2-5重组蛋白
  • 货号：
    CSB-MP015845RA
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Nkx2-5
  • Uniprot No.：
    O35767
  • 别名：
    Nkx2-5; Csx; Nkx-2.5; Nkx2e; Homeobox protein Nkx-2.5; rNKx-2.5; Homeobox protein NK-2 homolog E
  • 种属：
    Rattus norvegicus (Rat)
  • 蛋白长度：
    Full length protein
  • 表达区域：
    1-318
  • 氨基酸序列
    MFPSPALTHT PFSVKDILNL EQQQRSLAAG DLSARLEATL APASCMLAAF KPDGYSGPEA AAPGLAELRA ELGPAPSPPK CSPAFPTAPT FYPRAYGDPD PAKDPRADKK ELCALQKAVE LDKAETDGAE RRRPRRRRKP RVLFSQAQVY ELERRFKQQR YLSPAERDQL ASVLKLTSTQ VKIWFQNRRY KCKRQRQDQT LELLGPPPPP ARRIAVPVLV RDGKPCLGDS AAYAPAYGLG LNAYGYNAYP YPGYGGAACS PAYSCAAYPA APPAAHAPAA SANSNFVNFG VGDLNTVQSP GMPQGNSGVS TLHGIRAW
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Transcription factor required for the development of the heart and the spleen. During heart development, acts as a transcriptional activator of NPPA/ANF in cooperation with GATA4. May cooperate with TBX2 to negatively modulate expression of NPPA/ANF in the atrioventricular canal. Binds to the core DNA motif of NPPA promoter. Together with PBX1, required for spleen development through a mechanism that involves CDKN2B repression.
  • 基因功能参考文献：
    1. SIRT1 acts as a direct transcriptional target of Nkx2.5 that maintains cardiomyocyte homeostasis and survival. PMID: 23744058
    2. pacemaking cells originate from Nkx2.5 positive cardiac progenitor cells present in embryonic heart tubes PMID: 22527936
    3. novel function for Nkx2.5 as a repressor of alpha-SMA gene transcription, which may be of homeostatic significance as a means of suppressing myofibroblast differentiation PMID: 19395679
    4. Nkx2.5 regulates expression of Ca2+ channels in neonatal heart. PMID: 17498735
    5. p300 acts as an Nkx2.5 cofactor and facilitates increased Nkx2.5 activity by relieving the conformational impediment of its inhibitory C-terminal domain. PMID: 17544441

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  • 亚细胞定位：
    Nucleus.
  • 蛋白家族：
    NK-2 homeobox family
  • 数据库链接：

    KEGG: rno:114109

    STRING: 10116.ENSRNOP00000028155

    UniGene: Rn.6179

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