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  4. Recombinant Rat Histone deacetylase 4 (Hdac4), partial

Recombinant Rat Histone deacetylase 4 (Hdac4), partial

  • 中文名称：
    大鼠Hdac4重组蛋白
  • 货号：
    CSB-YP010240RA
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    大鼠Hdac4重组蛋白
  • 货号：
    CSB-EP010240RA
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    大鼠Hdac4重组蛋白
  • 货号：
    CSB-EP010240RA-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    大鼠Hdac4重组蛋白
  • 货号：
    CSB-BP010240RA
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    大鼠Hdac4重组蛋白
  • 货号：
    CSB-MP010240RA
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Hdac4
  • Uniprot No.：
    Q99P99
  • 别名：
    Hdac4; Histone deacetylase 4; HD4; EC 3.5.1.98
  • 种属：
    Rattus norvegicus (Rat)
  • 蛋白长度：
    Partial
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Involved in muscle maturation via its interaction with the myocyte enhancer factors such as MEF2A, MEF2C and MEF2D. Deacetylates HSPA1A and HSPA1B at 'Lys-77' leading to their preferential binding to co-chaperone STUB1.
  • 基因功能参考文献：
    1. the present study demonstrated that resveratrol attenuated AngIIinduced cell proliferation and neointimal hyperplasia by inhibiting the CaMKIIHDAC4 signaling pathway. These findings suggest that resveratrol may potentially prevent arterial restenosis. PMID: 29845301
    2. These results suggest that HDAC4 and HDAC8 may serve as key upstream mediators of MAPK in regulating the IL1betainduced cartilage catabolic and degradation. PMID: 29393346
    3. HDAC4 regulates thimerosal-induced cell death in neurons and that treatment with MC1568 prevents thimerosal-induced activation of caspase-3 in the rat prefrontal cortex. PMID: 27660204
    4. Our data suggest that nuclear HDAC4 accumulation in skeletal muscle is partly related to immobilization-induced muscle atrophy. PMID: 26759025
    5. Cx43 and HDAC4 mRNA expression first decreased and then increased compared to that in the control group; differences in HDAC4 mRNA expression were significant in the 1-week group. PMID: 27706732
    6. Phosphorylation of HDAC4 was remarkably upregulated after stroke and blockade of HDAC4 phosphorylation with GO6976 repressed stroke-induced angiogenesis. Phosphorylation of HDAC4 was also increased in endothelial cells hypoxia model and suppression of HDAC4 phosphorylation inhibited the tube formation and migration of endothelial cells in vitro. PMID: 28127553
    7. Melatonin -exhibited anti-allodynia is mediated by MT2-enhanced PP2Ac expression that couples PP2Ac with HDAC4 to induce HDAC4 dephosphorylation and nuclear import, herein increases HDAC4 binding to the promoter of hmgb1 gene and upregulates HMGB1 expression in dorsal horn neurons. PMID: 26732138
    8. chromatin immunoprecipitation experiments showed that NFAT1-HDAC4 or NFAT3-HDAC4 complexes might be involved in regulation of PMCA2x splicing variant generation. PMID: 24905014
    9. Neuropathic pain maintenance involves spinal HDAC4 phosphorylation and retention in dorsal horn neurons. PMID: 25871743
    10. Stroke induces nuclear shuttling of HDAC4 in neurons in the peri-infarct cortex. PMID: 25967576
    11. Thus, HDAC4 contributes to podocyte injury and is one of critical components of a signal transduction pathway that links renal injury to autophagy in diabetic nephropathy. PMID: 24717296
    12. Results highlight the unique nature of molecular signatures evoked by postnatal fluoxetine, and implicate HDAC4 in the dysregulated gene expression and emergence of perturbed emotionality following fluoxetine exposure in early life PMID: 24663010
    13. We examined whether HDAC4 controls vascular smooth muscle cell proliferation and migration. PMID: 24166750
    14. Oncogenic K-Ras modulates expression and localization of catenin and HDAC4 proteins in Rat2 cells. PMID: 23747726
    15. Nuclear exit of HDAC4 was prevented by downregulation of Nox4 in cultured neonatal rat cardiomyocytes. PMID: 23271793
    16. HDAC4 mediates development of hypertension via vascular inflammation in spontaneous hypertensive rats. PMID: 22389387
    17. cardiac hypertrophy pathological changes were largely blunted by silencing the CaMKIIdeltaA gene and an underlying mechanism indicated selective interference with the HDAC4-MEF2 signaling pathway. PMID: 21554860

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  • 亚细胞定位：
    Nucleus. Cytoplasm.
  • 蛋白家族：
    Histone deacetylase family, HD type 2 subfamily
  • 数据库链接：

    KEGG: rno:363287

    STRING: 10116.ENSRNOP00000027622

    UniGene: Rn.23483

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