Recombinant Rat Heat shock 70 kDa protein 4 (Hspa4), partial

1. The results showed that regular Hot-water immersion (HWI) resulted in lower HSP-70 expression than single HWI did in the organs, indicating that regular HWI caused less heat stress than single HWI. PMID: 29037410
2. Renal Hsp70 expression is decreased in spontaneously hypertensive rats before the development of hypertension. PMID: 27009470
3. Geranylgeranylacetone exerted beneficial effects in CCl4-induced liver fibrosis via upregulating the expression of HSP70. PMID: 26165998
4. These results suggest that electromagnetic preconditioning ameliorates calcium homeostasis through activating HSP70, thereby producing the cardioprotective effect and reduction in hypoxic cardiomyocytes damage. PMID: 26874210
5. Although endogenous 17beta-Estradiol in gonadally intact female rats may attenuate myocardial hsp70 mRNA accumulation, training maximizes this response in females, core temperature during exercise is still a greater stimulus to this response. PMID: 22039956
6. Expression of HSP70 reduced pulmonary arterial pressure and pulmonary vascular remodeling in neonatal rats with hypoxic pulmonary hypertension. PMID: 26903063
7. It was concluded that induction of HO-1 and HSP70 by celastrol prevents multiorgan injury and circulatory failure in endotoxemia. PMID: 25571843
8. The findings of the present study augment the understanding of the involvement of Hsp27 and Hsp70 in the response of the visual system to retinal ganglion cells degeneration. PMID: 25535743
9. decreased levels of Hsp70 were associated with the reduced protective effect on myocardial cells in vitro and in vivo. PMID: 25412361
10. Thus, it appears that HSP70 and alphaBC could play a neuroprotective role in permethrin-induced neurotoxicity. PMID: 23612524
11. Data suggest that the neuro-protective effect is likely achieved by anti-apoptotic mechanisms and is associated with over-expression of Heat-Shock Protein 70 (HSP70). PMID: 24496673
12. HSP70 protects against apoptotic cell death induced by NF-kappaB activation and NOS II-peroxynitrite signaling cascade in the hippocampal CA3 PMID: 24141017
13. Studied heat shock protein (HSP)70 immune reactivity and TUNEL positivity (apoptotic activity) in the liver of toluene-inhaled and melatonin-treated rats. PMID: 22438294
14. Hsp110 might play a fundamental role in opposing and alleviating heat-induced damage caused by hyperthermic stress in primary myocardial cells. PMID: 23315814
15. The transient elevation of synaptosomal mitoenergetic proteins and Hsp70 was found to occur early in a rat model of chronic cerebrovascular hypoperfusion. PMID: 22526757
16. Renal stress caused by brain death induces expression of the cytoprotective genes HO-1 and HSP70, but not of HSP27 and HSP40 PMID: 23356498
17. General anesthesia combined with epidural block can reduce the stress responses and protect cardiac myocytes by decreasing c-fos expression and increasing HSP70 expression in spontaneously hypertensive rats. PMID: 21097414
18. These results suggest that HSP70 was involved in the beneficial effects of hyperbaric oxygen preconditioning on decompression sickness in rats, suspected be by the antioxidation and antiapoptosis effects. PMID: 23479759
19. High doses of metabolites of B[a]P inhibit the expression of HSP70 in cultured cortical neurons in a dose- and time-dependent manner. PMID: 21861342
20. Increase of the glucocorticoid receptor and hsp70 in both hypothalamic cellular compartments is a response of naive rats to acute stress. PMID: 22350213
21. Excessive expression of HSP70 may cause injury to liver after severe multiple injury. PMID: 12857439
22. FK506 has dramatically neuroprotective effects against the development of acrylamide neuropathy, which may be related to up-regulating the expression of HSP70 and Bcl-2, and down-regulating the expression of Bax. PMID: 20465949
23. electromagnetic field exposure caused intensive staining for HSP27 and HSP70 in the hippocampus PMID: 22513040
24. Densitometric analysis revealed that exposure to a thermal stress induced expression of both Hsp27 and Hsp70 in bone marrow-derived mesenchymal stem cells and that the level of expression was dependant on stress exposure time. PMID: 22505291
25. Ulinastatin can protect the lung tissues by elevating the expression of hsp70 and reducing the expression of NF-kappaB in the lung tissues of rats with acute paraquat poisoning. PMID: 21941782
26. The expression of HSP70 mRNA in the hippocampus could be detected 4 h after diffuse axonal injury. It reached maximum expression at 24 h and declined after 48 h. PMID: 21913551
27. Microwave irradiation can obviously induce the thermal effect and activate HSP70 in the hippocampus. PMID: 20137302
28. systemic hypoxia increased the expression of heat shock protein 70 and caused gastric ulcers PMID: 22156356
29. After hepatic radiofrequency ablation, the degree of Hsp70 expression was significantly influenced by the distance from surrounding vasculature. PMID: 21109264
30. Hsp70 impairs apoptotic cellular pathways via interactions with caspases. PMID: 22132083
31. the physiologic rise in core temperature associated with exercise per se is not the key stimulus responsible for inducing hsp70 mRNA transcription in skeletal muscle myofibers PMID: 21953294
32. This study reveal distinct patterns of localization of hsp70 resident and infiltrating cells in TBI rat brain. PMID: 22067617
33. Mammalian Hsp110 (Apg-2), Hsp70 (Hsc70 or Hsp70) and Hsp40 (Hdj1) were necessary and sufficient to slowly dissolve large disordered aggregates and recover natively folded protein PMID: 22022600
34. purpose of this study was to establish the time of immunolocalization and distribution of HSP70 in developing and adult rat kidney. PMID: 21938673
35. These results indicate that psychological stress induces oxidative damage and up-regulates the expression of HSP70 in masseter muscles in rats, which are associated with behavior resembling anxiety. PMID: 21515294
36. HSP70 was increased in hippocampi of controlled cortical impact and post-traumatic epilepsy groups. PMID: 21439793
37. Data show that Hsp70 and Hsp32 protein were induced at 1 day post-status epilepticus and decreased thereafter, whereas Hsp25 exhibited a prolonged induction with increased levels at 3 and 7 days post-status epilepticus. PMID: 20971094
38. The role of HSP70 on photoreceptor survival after experimental retinal detachment (RD) was investigated in mice and rats. PMID: 21356360
39. Hsp70 plays a role in the cytoprotective effect of PC12 cells against sodium nitroprusside-induced cell death. PMID: 20559625
40. Elevation of heat shock protein 70 is associated with chronic heart failure. PMID: 19543852
41. expression of HSP 70 was observed in 30 minutes after brain injury, ncreased gradually, reached its peak at 12 hours and then declined at 24 hours. PMID: 19788071
42. Heat stress preconditioning is able to significantly attenuate this cognitive impairment, possibly mediated by the neuroprotective effect of HSP70. PMID: 19785543
43. As Hsp70 may transfer from glial to neuronal cells, its synthesis by astrocytes may represent an important survival mechanism by which astrocytes protect neurons against oxidative-mediated cell death PMID: 11990455
44. Hsp70 is translocated into the nucleus after heat shock and may attenuate PARS activation, protecting cardiomyocytes against Hypo/Reoxy injury PMID: 12870667
45. Overexpression of HSP70 in muscles of old transgenic mice prevented the specific force deficit observed in muscles of old WT mice PMID: 14688209
46. Microgravity differentially modulated the expression of HSP70 in osteoblasts PMID: 15033773
47. The chaperone HSP70 was found to be downregulated by IFN-gamma but upregulated by IFN-alpha. PMID: 15540463
48. interaction between Hsp70 and apoptosis-inducing factor might have reduced downstream events leading to cell death PMID: 15744251
49. Heat shock protein HSP70 increases the resistance of cortical cells to glutamate excitotoxicity. PMID: 16254606
50. These results suggest that HSP70 protects skeletal muscle against injury PMID: 16291818

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KEGG: rno:266759

STRING: 10116.ENSRNOP00000023628

UniGene: Rn.163092