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  4. Recombinant Rat Glutathione S-transferase Mu 1 (Gstm1)

Recombinant Rat Glutathione S-transferase Mu 1 (Gstm1)

  • 中文名称：
    大鼠Gstm1重组蛋白
  • 货号：
    CSB-YP009979RA
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    大鼠Gstm1重组蛋白
  • 货号：
    CSB-EP009979RA
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    大鼠Gstm1重组蛋白
  • 货号：
    CSB-EP009979RA-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    大鼠Gstm1重组蛋白
  • 货号：
    CSB-BP009979RA
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    大鼠Gstm1重组蛋白
  • 货号：
    CSB-MP009979RA
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Gstm1
  • Uniprot No.：
    P04905
  • 别名：
    Gstm1; Glutathione S-transferase Mu 1; EC 2.5.1.18; GST 3-3; GSTM1-1; Glutathione S-transferase Yb-1; GST Yb1
  • 种属：
    Rattus norvegicus (Rat)
  • 蛋白长度：
    Full Length of Mature Protein
  • 表达区域：
    2-218
  • 氨基酸序列
    PMILGYWNV RGLTHPIRLL LEYTDSSYEE KRYAMGDAPD YDRSQWLNEK FKLGLDFPNL PYLIDGSRKI TQSNAIMRYL ARKHHLCGET EEERIRADIV ENQVMDNRMQ LIMLCYNPDF EKQKPEFLKT IPEKMKLYSE FLGKRPWFAG DKVTYVDFLA YDILDQYHIF EPKCLDAFPN LKDFLARFEG LKKISAYMKS SRYLSTPIFS KLAQWSNK
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. The olfactory GST may be crucial for the acuity of the olfactory process. Participates in the formation of novel hepoxilin regioisomers.
  • 基因功能参考文献：
    1. GST-facilitated S-glutathionylation of AMPK may be involved in rapid, full activation of the kinase under mildly oxidative physiological conditions. PMID: 23741294
    2. GSTM1 and glutathione S-transferase theta;1 (GSTT1) null genotypes, together with hypertension, may play a significant role in the pathogenesis of ischemic stroke. PMID: 20517701
    3. Data describe the conformational stability of the chimeric homodimers M(12)-(12) and M(21)-(21) constructed from glutathione transferases M1-1 and M2-2. PMID: 12192076
    4. The enhanced product release rate by Y115F mutant GSTM1-1 enzyme is proposed to derive from a small shift in the equilibrium population of protein conformers that permit egress of the product (1-chloro-2,4-dinitrobenzene) from the active site. PMID: 12484753
    5. circulating testosterone or one of its metabolites regulates expression of Yb(1)-GST in basal cells of the corpus region indicating a differential regulation with respect to expression in the various cell types and regions of the epididymis. PMID: 12826697
    6. The present findings suggest that regulation of GST M1, and possibly GST A4, may mediate the anti-oxidative effects of valproate treatment, and regulation of GST may be involved in the mood stabilizing effect of valproate and lithium PMID: 15009649
    7. Highly significant, 4-fold reduction of glutathione S-transferase mu type 1 mRNA expression in stroke-prone spontaneously hypertension rat. One coding single nucleotide polymorphism (R202H) and multiple single nucleotide polymorphisms in promoter region. PMID: 15699453
    8. Simultaneous disruption of both motifs in the F56S/R81A mutant causes complete dissociation of the dimer to a monomeric protein on the basis of gel filtration chromatography and multiple-angle laser light scattering. PMID: 16475815
    9. the mu loop is not essential for GST M1 to maintain its structure nor is it required for the enzyme to retain some catalytic activity. However, it is an important determinant of the enzyme's affinity for its substrates. PMID: 16672236
    10. These results indicate that rats that are polymorphic for the GST M1 gene exhibit different susceptibilities to CF in vivo. PMID: 16800819

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  • 亚细胞定位：
    Cytoplasm.
  • 蛋白家族：
    GST superfamily, Mu family
  • 数据库链接：

    KEGG: rno:24423

    STRING: 10116.ENSRNOP00000039050

    UniGene: Rn.202944

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