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  4. Recombinant Rat Glutamate receptor-interacting protein 1 (Grip1), partial

Recombinant Rat Glutamate receptor-interacting protein 1 (Grip1), partial

  • 中文名称：
    大鼠Grip1重组蛋白
  • 货号：
    CSB-YP009921RA
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    大鼠Grip1重组蛋白
  • 货号：
    CSB-EP009921RA
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    大鼠Grip1重组蛋白
  • 货号：
    CSB-EP009921RA-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    大鼠Grip1重组蛋白
  • 货号：
    CSB-BP009921RA
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    大鼠Grip1重组蛋白
  • 货号：
    CSB-MP009921RA
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Grip1
  • Uniprot No.：
    P97879
  • 别名：
    Grip1Glutamate receptor-interacting protein 1; GRIP-1; AMPA receptor-interacting protein GRIP1
  • 种属：
    Rattus norvegicus (Rat)
  • 蛋白长度：
    Partial
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    May play a role as a localized scaffold for the assembly of a multiprotein signaling complex and as mediator of the trafficking of its binding partners at specific subcellular location in neurons. Through complex formation with NSG1, GRIA2 and STX12 controls the intracellular fate of AMPAR and the endosomal sorting of the GRIA2 subunit toward recycling and membrane targeting.
  • 基因功能参考文献：
    1. subcellular redistribution of GRIP1 and a change in the binding of GRIP1 to GluA2 during synaptic scaling, was observed. PMID: 26216979
    2. Data show that glutamate receptor-interacting protein-1 (GRIP1) is recruited to synapses under conditions of hypoactivity. PMID: 26109571
    3. GRIP1d is a 135 kDa, 7-PDZ-domain variant of GRIP1, containing the 12 amino acid C-terminus originally described for the 4-PDZ-domain GRIP1c 4-7. PMID: 16539648
    4. We propose that GRIP1 palmitoylation modulates NMDA-induced AMPAR internalisation by differential regulation of the early endosomal system PMID: 20837103
    5. GRIP1 and 2 regulate activity-dependent AMPA receptor recycling via exocyst complex interactions. PMID: 20956289
    6. Grip protein is important for postsynaptic as well as presynaptic maturation. PMID: 11931740
    7. Glutamate receptor interacting protein is localized in horizontal cells, dopaminergic and glycinergic AII amacrine cells and large ganglion cells of the retina. PMID: 12115684
    8. description of the three-dimensional structure of GRIP1 PDZ7 determined by NMR spectroscopy PMID: 12196542
    9. GRIP1c 4-7 plays a role not only in glutamatergic synapses but also in GABAergic synapses PMID: 15226318
    10. Data report the activation of serine racemase by glutamate neurotransmission involving AMPA receptors via glutamate receptor interacting protein and the physiologic regulation of cerebellar granule cell migration by SR. PMID: 15684087
    11. Repetitive synaptic activity triggers loss of synaptic GluR2-lacking AMPARs by selectively disrupting their interaction with GRIP and that PICK drives activity-dependent delivery of GluR2-containing receptors. PMID: 15895086
    12. In GABAergic synapses GRIP1a/b localizes both at the presynaptic terminals and postsynaptically, being frequently localized on the synaptic membranes or the synaptic junctional complex. PMID: 15912503
    13. functional transgenic GRIP1 protein is expressed in rat brain using lentiviral vectors containing a human synapsin I promoter PMID: 16157387
    14. about 85-kDa protein kinase phosphorylates GRIP1 on serine 917. This kinase is present in NEEP21 immunocomplexes and is activated in okadaic acid-treated neurons. PMID: 17121843

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  • 亚细胞定位：
    Cytoplasmic vesicle. Perikaryon. Cell projection, dendrite. Cytoplasm. Endomembrane system; Peripheral membrane protein. Cell junction, synapse, postsynaptic cell membrane. Cell junction, synapse, postsynaptic density. Endoplasmic reticulum membrane; Peripheral membrane protein.
  • 组织特异性：
    Expressed in brain, testis and retina. In brain highly expressed in the olfactory bulb, cortex and hyppocampus and lower level in thalamus, cerebellum and spinal cord. In brain it is found in the perikaryon, dendrites, dendritic shafts, dendritic spines a
  • 数据库链接：

    KEGG: rno:84016

    STRING: 10116.ENSRNOP00000005539

    UniGene: Rn.74240

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