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  4. Recombinant Rat Glutamate receptor, ionotropic kainate 1 (Grik1), partial

Recombinant Rat Glutamate receptor, ionotropic kainate 1 (Grik1), partial

  • 中文名称：
    大鼠Grik1重组蛋白
  • 货号：
    CSB-YP009906RA
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    大鼠Grik1重组蛋白
  • 货号：
    CSB-EP009906RA
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    大鼠Grik1重组蛋白
  • 货号：
    CSB-EP009906RA-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    大鼠Grik1重组蛋白
  • 货号：
    CSB-BP009906RA
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    大鼠Grik1重组蛋白
  • 货号：
    CSB-MP009906RA
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Grik1
  • Uniprot No.：
    P22756
  • 别名：
    Grik1; Glur5Glutamate receptor ionotropic; kainate 1; GluK1; Glutamate receptor 5; GluR-5; GluR5
  • 种属：
    Rattus norvegicus (Rat)
  • 蛋白长度：
    Partial
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Ionotropic glutamate receptor. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. Binding of the excitatory neurotransmitter L-glutamate induces a conformation change, leading to the opening of the cation channel, and thereby converts the chemical signal to an electrical impulse. The receptor then desensitizes rapidly and enters a transient inactive state, characterized by the presence of bound agonist. May be involved in the transmission of light information from the retina to the hypothalamus.
  • 基因功能参考文献：
    1. Signal peptide represses GluK1 surface and synaptic trafficking through binding to amino-terminal domain. PMID: 30451858
    2. In the CA1 hippocampal pyramidal cell, GluK1 had no effect on synaptic transmission. GluK1 which requires the auxiliary subunits Neto1 and Neto2 for surface and synaptic trafficking. It is the amino-terminal domains of GluK1 and GluK2 that control their strikingly different trafficking properties. PMID: 28100490
    3. Functional GluK1 (kainic acid)-containing receptors are present postsynaptically on vasopressin neurons but not on oxytocin cells. PMID: 22279215
    4. ATPA up-regulated mRNA and protein levels of GluR5, but coriaria lactone down-regulated GluR5 and GluR6 in astrocytes. PMID: 20848775
    5. Selective upregulation of kainate receptor subunit KA1 expression contributes to inflammatory hyperalgesia. PMID: 12359272
    6. Hippocampal mossy-fiber long-term potentiation is independent of GLUR5. PMID: 15537878
    7. High-resolution crystal structures of the GluR5 ligand-binding core complex with antagonists UBP302 & UBP310 show they bind by a new mechanism involving a 22-angstrom core extension. PMID: 16540562
    8. GluR5 subunit-containing kainate-type glutamate receptors have a role in the formation and/or stabilization of functional glutamatergic synapses in area CA1. PMID: 17569736
    9. Therefore, GLU(K5) kainate receptor subunits are involved in kindling-induced plasticity changes in the amygdala. PMID: 18046310
    10. analysis of how GluR5-containing kainate receptor activation has a role in neuroprotection against ischemic brain injury through decreasing tyrosine phosphorylation of N-methyl-D-aspartate receptors mediated by Src kinase PMID: 18678878
    11. Kainate receptors containing the GLU(K5) subunit are critically important for generation and frequency oscillation in the entorhinal cortex. PMID: 19043593
    12. study demonstrates there is a tonic effect on inhibitory synaptic transmission in hippocampal CA1 pyramidal cells regulated by endogenous glutamate via GluR5 kainate receptor which is age dependent PMID: 19123252

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  • 亚细胞定位：
    Cell membrane; Multi-pass membrane protein. Cell junction, synapse, postsynaptic cell membrane; Multi-pass membrane protein.
  • 蛋白家族：
    Glutamate-gated ion channel (TC 1.A.10.1) family, GRIK1 subfamily
  • 组织特异性：
    Expressed in subsets of neurons throughout the developing and adult central and peripheral nervous systems. In the CNS principally in the medial amygdaloid nuclei, medial habenulae, pyriform and cingulate cortices, and Purkinje cell layer. Also highly exp
  • 数据库链接：

    KEGG: rno:29559

    STRING: 10116.ENSRNOP00000045594

    UniGene: Rn.10449

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