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  4. Recombinant Rat Glutamate dehydrogenase 1, mitochondrial (Glud1)

Recombinant Rat Glutamate dehydrogenase 1, mitochondrial (Glud1)

  • 中文名称：
    大鼠Glud1重组蛋白
  • 货号：
    CSB-YP009544RA
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    大鼠Glud1重组蛋白
  • 货号：
    CSB-EP009544RA
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    大鼠Glud1重组蛋白
  • 货号：
    CSB-EP009544RA-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    大鼠Glud1重组蛋白
  • 货号：
    CSB-BP009544RA
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    大鼠Glud1重组蛋白
  • 货号：
    CSB-MP009544RA
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Glud1
  • Uniprot No.：
    P10860
  • 别名：
    Glud1; GludGlutamate dehydrogenase 1; mitochondrial; GDH 1; EC 1.4.1.3; Memory-related gene 2 protein; MRG-2
  • 种属：
    Rattus norvegicus (Rat)
  • 蛋白长度：
    Full Length of Mature Protein
  • 表达区域：
    54-558
  • 氨基酸序列
    SEAATDR EDDPNFFKMV EGFFDRGASI VEDKLVEDLK TRENEEQKRN RVRGILRIIK PCNHVLSLSF PIRRDDGSWE VIEGYRAQHS QHRTPCKGGI RYSTDVSVDE VKALASLMTY KCAVVDVPFG GAKAGVKINP KNYTDNELEK ITRRFTMELA KKGFIGPGID VPAPDMSTGE REMSWIADTY ASTIGHYDIN AHACVTGKPI SQGGIHGRIS ATGRGVFHGI ENFINEASYM SILGMTPGLG DKTFVVQGFG NVGLHSMRYL HRFGAKCVGV GESDGSIWNP DGIDPKELED FKLQHGSILG FPKAKVYEGS ILEADCDILI PAASEKQLTK SNAPRVKAKI IAEGANGPTT PEADKIFLER NIMVIPDLYL NAGGVTVSYF EWLKNLNHVS YGRLTFKYER DSNYHLLMSV QESLERKFGK HGGTIPVVPT AEFQDRISGA SEKDIVHSGL AYTMERSARQ IMRTAMKYNL GLDLRTAAYV NAIEKVFKVY NEAGVTFT
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Mitochondrial glutamate dehydrogenase that converts L-glutamate into alpha-ketoglutarate. Plays a key role in glutamine anaplerosis by producing alpha-ketoglutarate, an important intermediate in the tricarboxylic acid cycle. Plays a role in insulin homeostasis. May be involved in learning and memory reactions by increasing the turnover of the excitatory neurotransmitter glutamate.
  • 基因功能参考文献：
    1. Findings demonstrate that hippocampal synapse assembly and maintenance require a tripartite molecular complex in which the ligand Cbln2 binds with presynaptic neurexin 1beta (+S4) and postsynaptic GluD1. PMID: 29784783
    2. Glutamate dehydrogenase is differentially regulated in liver and muscle of rats with transplanted Guerin's carcinoma. PMID: 24319738
    3. We find that SIRT4 and GDH1 overexpression play antagonistic roles in regulating gliogenesis PMID: 23281078
    4. GDH activity is involved in activation of insulin secretion. PMID: 20332361
    5. GDH1 facilitates regeneration of BCATm that binds to E1 decarboxylase of the branched-chain alpha-keto acid dehydrogenase enzyme complex, promotes metabolon formation, branched-chain amino acid oxidation, and cycling of nitrogen through glutamate. PMID: 19858196
    6. during acidosis, the pH-responsive stabilization of glutamate dehydrogenase mRNA may be accomplished by the same mechanism that affects an increase in mitochondrial glutaminase mRNA PMID: 12684230
    7. inhibition of glutamate dehydrogenase results in sulfite neurotoxicity PMID: 15273247

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  • 亚细胞定位：
    Mitochondrion. Endoplasmic reticulum.
  • 蛋白家族：
    Glu/Leu/Phe/Val dehydrogenases family
  • 组织特异性：
    Widely expressed throughout the hippocampus. After induction by training, highly expressed in the dentate gyrus, pyrimidal layer and lacunosum moleculare.
  • 数据库链接：

    KEGG: rno:24399

    STRING: 10116.ENSRNOP00000013789

    UniGene: Rn.55106

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