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  4. Recombinant Rat Gamma-aminobutyric acid type B receptor subunit 2 (Gabbr2), partial

Recombinant Rat Gamma-aminobutyric acid type B receptor subunit 2 (Gabbr2), partial

  • 中文名称：
    大鼠Gabbr2重组蛋白
  • 货号：
    CSB-YP009135RA
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    大鼠Gabbr2重组蛋白
  • 货号：
    CSB-EP009135RA
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    大鼠Gabbr2重组蛋白
  • 货号：
    CSB-EP009135RA-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    大鼠Gabbr2重组蛋白
  • 货号：
    CSB-BP009135RA
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    大鼠Gabbr2重组蛋白
  • 货号：
    CSB-MP009135RA
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Gabbr2
  • Uniprot No.：
    O88871
  • 别名：
    Gabbr2; Gpr51; Gamma-aminobutyric acid type B receptor subunit 2; GABA-B receptor 2; GABA-B-R2; GABA-BR2; GABABR2; Gb2; G-protein coupled receptor 51
  • 种属：
    Rattus norvegicus (Rat)
  • 蛋白长度：
    Partial
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Component of a heterodimeric G-protein coupled receptor for GABA, formed by GABBR1 and GABBR2. Within the heterodimeric GABA receptor, only GABBR1 seems to bind agonists, while GABBR2 mediates coupling to G proteins. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling inhibits adenylate cyclase, stimulates phospholipase A2, activates potassium channels, inactivates voltage-dependent calcium-channels and modulates inositol phospholipid hydrolysis. Plays a critical role in the fine-tuning of inhibitory synaptic transmission. Pre-synaptic GABA receptor inhibits neurotransmitter release by down-regulating high-voltage activated calcium channels, whereas postsynaptic GABA receptor decreases neuronal excitability by activating a prominent inwardly rectifying potassium (Kir) conductance that underlies the late inhibitory postsynaptic potentials. Not only implicated in synaptic inhibition but also in hippocampal long-term potentiation, slow wave sleep, muscle relaxation and antinociception.
  • 基因功能参考文献：
    1. Study provided evidence that GABAB2 subunit is involved in anxiety-like behaviours induced by chronic cerebral hypoperfusion. Activation of GABAB2 subunits could improve BDNF/TrkB/NCAM signalling and reverse Kir3 channel surface expressions in hippocampal CA1, which may alleviate the anxiety-like behaviours in rats with chronic cerebral hypoperfusion. PMID: 27515806
    2. Gabbr2 exists in rat brain at birth and decreases between birth and PD15. PMID: 24020808
    3. GABABR activation reduces cyclic AMP-dependent phosphorylation of LKB1, a kinase involved in neuronal polarization, and rescues LKB1 overexpression-induced defects in cortical development. PMID: 23653212
    4. GABA(B)R2 proteins are reduced in the prefrontal cortex of aged rats but these reductions are not associated with spatial learning abilities. PMID: 22169202
    5. Regional distribution of GABABR2 in auditory neurons matches their inputs; the cellular localization of GABABR2 in auditory neurons fits the synaptic responses in these cells. PMID: 21371537
    6. Adult stem cells from rat adipose tissue or bone marrow were found to express GABA-B2 receptor subunits. GABA-B receptors in differentiated adipose tissue stem cells are functionally active, regulating a key process such as proliferation. PMID: 21618582
    7. Gamma-aminobutyric acid type B (GABA(B)) receptor internalization is regulated by the R2 subunit. PMID: 21724853
    8. Data show that recurrent febrile seizure down-regulated the expression of GABA(B)R2 in a long term. PMID: 17044980
    9. In the brain GABA B receptor 2, but not GABA B receptor 1, biochemically coprecipitates with M2 muscarinic receptors and overlaps with muscarinic M2 receptor expression in cortical neurons. PMID: 20016095
    10. An increased expression of GABA(B2) receptor subunits was seen in somatosensory cerebral cortex, ventrobasal thalamus and reticular thalamic nuclei in genetic absence seizure rats compared to controls. PMID: 12948615
    11. GABA(B)R2 protein is produced in rat testis and sperm and may play a role in GABA triggering of the acrosome reaction PMID: 14967916
    12. Oxygen-glucose deprivation or NMDA produced a ~75% decrease in GABA(B2)levels. Because GABA(B2) is needed for functional surface expression, its down-regulation removes an important inhibitory feedback mechanism under pathological conditions. PMID: 19328818

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  • 亚细胞定位：
    Cell membrane; Multi-pass membrane protein. Cell junction, synapse, postsynaptic cell membrane; Multi-pass membrane protein. Perikaryon. Cell projection, dendrite.
  • 蛋白家族：
    G-protein coupled receptor 3 family, GABA-B receptor subfamily
  • 组织特异性：
    Highly expressed in areas of the brain including thalamic nuclei, the hippocampus, cerebellar Purkinje cells and the medial habenula, and moderately expressed in the cerebral cortex, certain anterioventral thalamic nuclei, dorsal medial hypothalamic nucle
  • 数据库链接：

    KEGG: rno:83633

    STRING: 10116.ENSRNOP00000011573

    UniGene: Rn.162814

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