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  4. Recombinant Rat Gamma-aminobutyric acid receptor subunit alpha-1 (Gabra1), partial

Recombinant Rat Gamma-aminobutyric acid receptor subunit alpha-1 (Gabra1), partial

  • 中文名称：
    大鼠Gabra1重组蛋白
  • 货号：
    CSB-YP009140RA
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    大鼠Gabra1重组蛋白
  • 货号：
    CSB-EP009140RA
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    大鼠Gabra1重组蛋白
  • 货号：
    CSB-EP009140RA-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    大鼠Gabra1重组蛋白
  • 货号：
    CSB-BP009140RA
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    大鼠Gabra1重组蛋白
  • 货号：
    CSB-MP009140RA
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Gabra1
  • Uniprot No.：
    P62813
  • 别名：
    Gabra1; Gabra-1; Gamma-aminobutyric acid receptor subunit alpha-1; GABA(A) receptor subunit alpha-1
  • 种属：
    Rattus norvegicus (Rat)
  • 蛋白长度：
    Partial
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Ligand-gated chloride channel which is a component of the heteropentameric receptor for GABA, the major inhibitory neurotransmitter in the brain. Plays an important role in the formation of functional inhibitory GABAergic synapses in addition to mediating synaptic inhibition as a GABA-gated ion channel. The gamma2 subunit is necessary but not sufficient for a rapid formation of active synaptic contacts and the synaptogenic effect of this subunit is influenced by the type of alpha and beta subunits present in the receptor pentamer. The alpha1/beta2/gamma2 receptor and the alpha1/beta3/gamma2 receptor exhibit synaptogenic activity. GABRA1-mediated plasticity in the orbitofrontal cortex regulates context-dependent action selection. Functions also as histamine receptor and mediates cellular responses to histamine.
  • 基因功能参考文献：
    1. Study presents the kinetic model of GABAAR postulating that openings of singly and doubly bound receptors are preceded by flipping and that the receptor may show also unflipped openings at unbound, fully bound and possibly at singly bound ligations. Moreover, results confirm that mutation of alpha1Phe64 residue strongly affects flipping and extend this finding by observation that opening/closing is also affected. PMID: 29162430
    2. GABAA receptor alpha5 subunit (alpha5GABAAR) expression in hippocampal neurons was significantly lower in rats receiving chloroform on PND 3 than in rats in other groups. PMID: 29667127
    3. almost two-thirds of parvalbumin neurons co-express high concentrations of alpha1 subunit of GABAA receptor PMID: 28834708
    4. Study indicates that unilateral 6-OHDA lesions of the substantia nigra pars compacta in rats change GABAA receptor-mediated inhibitory transmission in the lateral habenula (LHb), with findings including decreased GABA synthesis and release in the LHb, increased firing activity of the neurons and up-regulation of alpha1 subunit-containing GABAA receptors. PMID: 28109827
    5. excitotoxicity and brain ischemia downregulate full-length gephyrin with a concomitant generation of truncated products, which affect synaptic clustering of GABAAR and cell death. PMID: 26093381
    6. This study reveals that Rac1-dependent GABAAR endocytosis plays a crucial role in extinction of aversive memories associated with drug withdrawal and identifies Arc as a downstream effector of Rac1 regulations of synaptic plasticity as well as learning and memory, thereby suggesting therapeutic targets to promote extinction of the unwanted memories. PMID: 28630256
    7. These data suggest a major role for central GABAA receptors in the inflammatory and cardiovascular effects of endotoxemia PMID: 26685896
    8. The GABAA receptor mediates propofol-induced apoptosis and proliferation inhibition of rENSCs, possibly by modulating the Chk1/p53 signaling pathway. PMID: 26600553
    9. Sp4 functionally regulates the transcription of Gabra1 (GABAA alpha1) and Gabra2 (GABAA alpha2), but not Gabra3 (GABAA alpha3) subunit genes. PMID: 26469128
    10. Data show that Valerian extract inhibits hepatocarcinogenesis by suppressing cell proliferation and inducing apoptosis in glutathione S-transferase pi GST-P(+) foci by activating gamma-aminobutyric acid A receptor GABA(A)RA1-mediated signaling. PMID: 25419570
    11. Extracellular ATP allosterically potentiates GABAAR-gated chloride channels. PMID: 24456563
    12. Data indicate that GABAA receptor (GABAAR) modulators inhibited [(14)C]TETS (tetramethylenedisulfotetramine) binding, providing an in vitro system for recognizing candidate antidotes. PMID: 24912155
    13. Regulation of GABA A receptors is important for management of renal dysfunction. PMID: 24154851
    14. GABAA receptors were functionally expressed in bladder innervating neurons. PMID: 24704426
    15. The inhibitory-to-excitatory switch of GABA A receptor-mediated transmission in arginine-vasopressin (AVP) neurons contributes to the generation of sodium-dependent hypertension by increasing AVP release. PMID: 24103391
    16. During adolescence, but not adulthood, binge-pattern ethanol exposure causes persistent changes in GABA A receptor-mediated tonic inhibition in dentate granule cells. PMID: 23413887
    17. Inhibition of the lateral hypothalamus through modulation of GABA(A) receptors (and NMDA receptors) suppresses feeding. PMID: 23164617
    18. Tonic inhibition via extrasynaptic GABAA receptors that contain a delta subunit may be one mechanism by which the extracellular pool of endogenous GABA in the rostral pontine reticular formation promotes wakefulness. PMID: 23450652
    19. These results support an integral role for miRNA-mediated transcriptional deregulation of the GABAergic system in neonatal cystitis-induced chronic pelvic pain. PMID: 23273104
    20. the vasorelaxatory effect of GABA is mediated by the GABAA receptor and nitric oxide in both STZ diabetic and non-diabetic vessels PMID: 23531839
    21. The aging process involves declines in neural benzodiazepine recognition site availability, proposed to reflect alterations in GABA(A) receptor subunit polypeptide expression. PMID: 21272959
    22. Data indicate there was an inverse correlation between depressive-like behaviors and GABA(A)R alpha1 subunit mRNA expression in the right hemisphere in female and progesterone decreased the GABA(A)R gamma2 mRNA expression only in the left hemisphere of male. PMID: 22806324
    23. GABA(A) receptor expression level in caudal vestibular nucleus is associated with motion sickness habituation. PMID: 22608069
    24. GABA(A)-mediated inhibition modulates stimulus-specific adaptation in the inferior colliculus PMID: 22479591
    25. This study demonistrated that up-regulation of the GABA(A)alpha1 a 3 weeks after the last stimulation session. PMID: 22546338
    26. presence of alpha2 and alpha3 subunits during early development might make them more amenable to becoming sensitized by environmental stressors, whereas the relative paucity of alpha1 subunits at this age might limit the sensitization of this subunit. PMID: 22044189
    27. The GABA A receptor alpha1-gamma2 subunit interface structure undergoes agonist-specific conformational changes. PMID: 22572883
    28. Data show that vasoactive peptide urotensin II receptor and GABA(A)R are co-expressed in cerebellar glial cells from rat brain slices, in human native astrocytes and in glioma cell line. PMID: 22563490
    29. GABA(A)Ralpha and GlyRalpha1 undergo differential changes in expression during the development of the cerebral cortex. PMID: 22018691
    30. neuroplastin-65 can co-localize with a subset of GABA(A) receptor subtypes and might contribute to anchoring and/or confining GABA(A) receptors to particular synaptic or extra-synaptic sites, thus affecting receptor mobility and synaptic strength PMID: 22389504
    31. This study demonstrated that diversity in the decay of IPSCs can be generated by varying the expression of different GABA(A)R subunits that alone confer different decay kinetics, allowing the time course of inhibition. PMID: 22539847
    32. Data suggest that cardiovascular responses to stress are mediated by the nucleus raphe pallidus and likely involve 5HT1A and GABA A receptors. PMID: 21982918
    33. No change in alpha 1 subunit expression was seen in hippocampi of controlled cortical impact and post-traumatic epilepsy groups. PMID: 21439793
    34. Excessive expression of GAT-1 as well as GAT-3 and GABA receptor alpha1 subunits in hippocampal tremor may provide potential therapeutic targets for genetic epilepsy. PMID: 20851161
    35. In conclusion, these cyclic large IPSC events observable in CA3 pyramidal neurons in 10 mM KCl may be due to transient GABA depletion from continuously active interneuronal afferents. PMID: 21209355
    36. Results describe the differential cellular distribution of alpha1, alpha2 and alpha3 GABA(A) receptor subunits in relation to striatopallidal (Str-GP) and pallidopallidal (GP-GP) synapses. PMID: 21219474
    37. Results indicate that GABAA receptors accelerate fetal lung development, likely through an enhanced cell proliferation and/or fluid secretion. PMID: 21152393
    38. GABA(A) receptors in rats have many biological responses including sedative, anxiolytic, anticonvulsant and anesthetic actionscan. The receptors can be modulated by allopregnanolone via its pharmacological and pathophysiological actions. PMID: 21118679
    39. GABA(A) receptor alpha1 subunit was expressed in the flocculus after unilateral labyrinthectomy. PMID: 16398052
    40. Analysis of GABAA receptor alpha1 subunit in rat brain. PMID: 20191118
    41. Effects on the expression of Gabra1 by diazepam treatment in rat hippocampus neurons are reported. PMID: 20083184
    42. Enhancement of GABA(A)-current run-down in the hippocampus occurs at the first spontaneous seizure in a model of temporal lobe epilepsy. PMID: 20133704
    43. Protein kinase C gamma regulates GABA(A) alpha1 receptor trafficking after ethanol exposure. PMID: 20159950
    44. The expression of both GABA and GABA(A)R-alpha1 decreased in the brains of the high-dose tetramine poisoned rat group. PMID: 17619448
    45. Elevated quantities of GABA(A) receptor alpha-1 subunit mRNA in the rat are related to the highly advanced behavioral and mnemonic strategies that are under the control of the telencephalon in this mammal. PMID: 11845246
    46. Rat brain cholinergic, dopaminergic, noradrenergic and serotonergic neurons express GABAA receptors derived from the alpha3 subunit. PMID: 11918349
    47. Distinct alpha subunit contributions create heterogeneity in developmental acceleration of IPSC decay in neocortex. PMID: 12433958
    48. The Pro174-Asp191 segment of thie receptor is involved in GABA binding and channel gating. PMID: 12556472
    49. the relative expression levels of GABA(A) alpha(1,2) receptor subunits favor GABA(A) receptors susceptible to positive modulation by progesterone metabolites PMID: 12763608
    50. expression of alpha(1) subunit mRNA for GABA(A) receptor and levels of GABA IR in the substantia nigra pars reticulata are sex- and site-specific; may contribute to sex-, regional- and age-related differences in expression of movement disorders & seizures PMID: 12850057

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  • 亚细胞定位：
    Cell junction, synapse, postsynaptic cell membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein. Cytoplasmic vesicle membrane.
  • 蛋白家族：
    Ligand-gated ion channel (TC 1.A.9) family, Gamma-aminobutyric acid receptor (TC 1.A.9.5) subfamily, GABRA1 sub-subfamily
  • 组织特异性：
    Expressed in brain (at protein level).
  • 数据库链接：

    KEGG: rno:29705

    STRING: 10116.ENSRNOP00000004725

    UniGene: Rn.28463

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