Recombinant Rat Extracellular calcium-sensing receptor (Casr), partial

1. CaSR was detected in rat cornea, lens, and retina. It was significantly decreased in the eyes of diabetic rats. PMID: 29397395
2. these results suggest that high glucose induces myocardial energy metabolism disorder via decrease of CaSR expression, and activation of gp78-ubiquitin proteasome system. PMID: 28518143
3. Calcium sensing receptor (CaSR) was increased in the aortas from spontaneous hypertensive rats (SHRs) compared with age-matched Wistar Kyoto (WKY) rats. PMID: 29128361
4. These findings indicate that cardiac function could be enhanced significantly by combination therapy with CaSR inhibition and ESC transplantation; the effect was better than ESC transplantation alone, and the mechanism might be associated with a reduction in cell apoptosis via the inhibition of the MAPK pathway. PMID: 28281186
5. Monocrotaline aggregates on and activates the CaSR of pulmonary artery endothelial cells to trigger endothelial damage and, ultimately, induces pulmonary hypertension. PMID: 28330842
6. ET-1 causes an adaptive type of hypertrophy by up-regulation of CaR in cardiomyocytes via ETA and/or ETB1 receptors. PMID: 27662515
7. reduced expression of the CaSR is correlated with activation of the renin-angiotensin system, which induces increased vascular remodeling and vascular smooth muscle cell proliferation, and thereby associated with essential hypertension in the SHR rat model and in the Han Chinese population PMID: 27391973
8. VS-105 exerts a rapid effect on suppressing serum PTH, directly down-regulates the PTH gene, and modulates PTH, VDR and CaSR gene expression more effectively than paricalcitol PMID: 27989797
9. Our results demonstrated that CaSR activation induced cardiomyocyte apoptosis through the mitochondrial dynamics mediated apoptotic pathway in hypertensive hearts. PMID: 28450119
10. The results showed that the [Ca(2+)]i and the expression of p-CaMK and CSE increased upon treatment with CaSR agonist. PMID: 27502588
11. Results demonstrate that selective and long-lasting astroglial induction of CaSR expression is a common characteristic of ischemic brain injury and suggest its involvement in the ischemia-induced astroglial reaction PMID: 27288786
12. The binding of HIMF enhanced the activity of extracellular CaSR and mediated hypoxia-evoked proliferation of pulmonary artery smooth cells and the development of pulmonary vascular remodeling and pulmonary hypertension PMID: 28348014
13. Calcium oxalate-induced renal injury is related to CaSR-mediated oxidative stress and increased mitogen-activated protein kinase signaling, which subsequently leads to CaOx crystal adhesion. PMID: 27965733
14. Secondary hyperparathyroidism results in reduction of calcium-sensing receptor (CaSR) and vitamin D receptor (VDR) in the parathyroid glands during CKD. PMID: 27589858
15. CaSR might play significant roles in the induction of hippocampus apoptosis in rat during hypoxia/reoxygenation through phosphorylation of ERK1/2. PMID: 26617793
16. fluoride might be able to affect calcium homeostasis by regulating PTH, PTHrP, and CaSR PMID: 25645361
17. Casr is associated with the development of insulin resistance in rats fed a high-fat diet and suggested that Casr may be important in the pathogenesis of diabetes. PMID: 25892159
18. The CaSR/NLRP3 inflammasome plays an essential role via the PLC-IP3 pathway. PMID: 25967877
19. CaSR is involved in the pulmonary vascular remodeling and pulmonary hypertension by promoting phenotypic modulation of small pulmonary arteries. PMID: 25063217
20. Role of calcium-sensing receptor in cardiac injury of hereditary epileptic rats PMID: 25572699
21. The roles of the calcium-sensing receptor (CaSR) and L-type voltage-dependent calcium channel (L-VDCC) in the proliferation and osteogenic differentiation of a calcium-exposed periodontal ligament stem/progenitor cells, were investigated . PMID: 24842051
22. Elevating [Ca(2+)]o induced SOCE by triggering the activation of CaSR and PLC PMID: 25254954
23. suggested that hypoxia increased [Ca(2+)]i by elevated CaSR expression to promote BACE1 expression, thereby resulting in the overproduction of Abeta42 and Abeta40 PMID: 25747709
24. This study demonstrated the expression of BK and its coexpression with CaSR and TRPV1 channels in rat bronchopulmonary sensory neurons PMID: 25192641
25. CaSR activation promoted the expression of TRPC3 and TRPC6 and enhanced T lymphocytes apoptosis through PLC-IP3 signaling pathway in sepsis. PMID: 25467798
26. CaSR activation promoted T-cell apoptosis and the secretion of pro-inflammatory cytokine TNF-alpha and anti-inflammatory cytokines IL-4. PMID: 25256599
27. activation of gut calcium-sensing receptor (CaSR) by dietary peptides reduces glycemic responses so that gut CaSR may be a potential target for the improvement of postprandial glycemia PMID: 24812056
28. CaSR interferes with TGF-beta-dependent Smad2 phosphorylation and induces its proteasomal degradation. PMID: 24273150
29. CaSR functions not through its expression, but rather through allosteric regulation in obese individuals. PMID: 23740560
30. Increased luminal calcium concentration leads to enhanced fluid reabsorption in the proximal tubule, a process related to activation of CaSR. PMID: 23615500
31. LPS-induced cardiomyocyte injury is related to CaSR-mediated cardiomyocyte apoptosis. PMID: 23564188
32. Calcium-sensing receptor palys an important role in sarcoplasmic reticulum-mitochondrial inter-organelle ca2+ signaling through IP3Rs, which are also involved in apoptosis during heart failure. PMID: 23711498
33. Upregulated expression & enhanced function of CaSR in pulmonary artery smooth myocytes are involved in the development of sustained pulmonary vasoconstriction & pulmonary vascular remodeling in rats with experimental pulmonary hypertension. PMID: 23300272
34. Calcium-sensing receptor enhances the nuclear Ca(2+) transient in cardiomyocytes by increasing fractional Ca(2+) release from perinuclear stores, which is involved in cardiac hypertrophy through the Calcineurin/NFAT pathway. PMID: 22708524
35. results demonstrate that CaSR is involved in bone marrow derived mesenchymal stem cell proliferation and provide important insight into the cellular and molecular mechanisms by which CaSR affects cell proliferation PMID: 22314915
36. activation of mitochondrial hydrogen peroxide sensitized CaSR mediates hypoxia induced vasoconstriction in pulmonary artery PMID: 22098336
37. The extracellular calcium-induced increase in cytosolic Ca(2+) due to upregulated CaSR, contributes to the augmented Ca(2+) influx and excessive pulmonary artery smooth muscle cell proliferation in pulmonary arterial hypertension. PMID: 22730443
38. increased expression of CaSR may be one of molecular mechanisms underlying acute myocardial infarction in atherosclerosis. PMID: 22527939
39. the CaSR expression of myocardium is reduced in the progress of DCM, and its potential mechanism is related to the impaired intracellular calcium homeostasis. PMID: 22137362
40. Calcium-sensing receptor mediates oxidized low-density lipoprotein-induced MMP-2 production in vascular smooth muscle cells via PI3K/Akt signal pathway. PMID: 22083546
41. several active conformations of CaSR, stabilized by different molecules, exist, which affect intracellular signaling distinctly. PMID: 22192592
42. Data suggest that regulation of basolateral K channels by the Ca++ sensing receptor may be the mechanism by which extracellular Ca2+ level modulates the reabsorption of divalent cations. PMID: 22050992
43. Data suggest that Casr is expressed in smooth muscle layers of uterus (and in endometrium); Casr ligands relax longitudinally orientated uterine strips; however, role of Casr in regulation of uterine contractility remains uncertain. PMID: 22013999
44. CaSR in adipocytes may be involved in the pathogenesis of obesity by promoting adipocyte differentiation and adipogenesis PMID: 22038624
45. Simulated I/R increased the expression of CaSR and induced apoptosis in BRL cells. PMID: 21692826
46. The involvement of CaSR in cardiac apoptosis through the mitochondrial pathway during ischemia/reperfusion is related to phospho-PKCdelta translocation to the mitochondria. PMID: 21766206
47. CaSR promotes cellular adhesion and migration via coupling to members of the integrin family of extracellular matrix-binding proteins PMID: 21969374
48. Hepatocyte growth factor exerts a protective role in ischemia/reperfusion induced cardiomyocyte apoptosis at least in part by inhibiting CaSR mRNA expression. PMID: 21215232
49. CaSR is associated with I/R injury and apoptosis in neonatal rat ventricular cardiomyocytes. PMID: 21488219
50. CaSR is expressed in rat pulmonary artery smooth muscle cells (PASMCs), and is involved in regulation of pulmonary artery tension by increasing [Ca2+]i through G-PLC-IP3 pathway. PMID: 21314926

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KEGG: rno:24247

STRING: 10116.ENSRNOP00000003092

UniGene: Rn.10019