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  4. Recombinant Rat Espin (Espn), partial

Recombinant Rat Espin (Espn), partial

  • 中文名称：
    大鼠Espn重组蛋白
  • 货号：
    CSB-YP007827RA
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    大鼠Espn重组蛋白
  • 货号：
    CSB-EP007827RA
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    大鼠Espn重组蛋白
  • 货号：
    CSB-EP007827RA-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    大鼠Espn重组蛋白
  • 货号：
    CSB-BP007827RA
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    大鼠Espn重组蛋白
  • 货号：
    CSB-MP007827RA
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Espn
  • Uniprot No.：
    Q63618
  • 别名：
    EspnEspin; Ectoplasmic specialization protein
  • 种属：
    Rattus norvegicus (Rat)
  • 蛋白长度：
    Partial
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Multifunctional actin-bundling protein. Plays a major role in regulating the organization, dimension, dynamics and signaling capacities of the actin filament-rich microvilli in the mechanosensory and chemosensory cells. Required for the assembly and stabilization of the stereociliary parallel actin bundles. Plays a crucial role in the formation and maintenance of inner ear hair cell stereocilia. Involved in the elongation of actin in stereocilia. In extrastriolar hair cells, required for targeting MYO3B to stereocilia tips, and for regulation of stereocilia diameter and staircase formation.
  • 基因功能参考文献：
    1. Following hypophysectomy, the actin cytoskeleton of the Sertoli cell shifts to a predominantly depolymerized state, perhaps in part because of decreases in profilin II and espin gene products. PMID: 15477377
    2. Espin is expressed in the epididymis and is regulated by androgens. PMID: 17409466
    3. Localization of espins to a large proportion of rat type I spiral ganglion neurons (SGNs) and their projections to the cochlear nucleus. PMID: 18551532
    4. This study provides the basis for understanding the role of myosin IIIa and espin 1 in regulating stereocilia length. PMID: 19287378
  • 亚细胞定位：
    Cytoplasm, cytoskeleton. Cell projection, stereocilium. Cell projection, microvillus. Cell junction.; [Isoform 1]: Cytoplasm, cytoskeleton. Cell junction. Note=Isoform 1 localizes to parallel actin bundles of ectoplasmic specializations between neighboring Sertoli cells and at sites where Sertoli cells contact the heads of elongate spermatids.; [Isoform 2]: Cytoplasm, cytoskeleton. Cell projection, microvillus. Note=Isoform 2 localizes to parallel actin bundles of brush border microvilli of small intestine and kidney.; [Isoform 3]: Cytoplasm, cytoskeleton. Cell projection, dendritic spine.; [Isoform 4]: Cytoplasm, cytoskeleton. Cell projection, dendritic spine.; [Isoform 6]: Cytoplasm, cytoskeleton. Cell projection, dendritic spine.; [Isoform 8]: Cytoplasm, cytoskeleton. Cell projection, dendritic spine.
  • 组织特异性：
    Expressed at high concentration in the microvillar parallel actin bundle (PAB) of hair cells stereocilia in the cochlea and vestibular system. Detected also at high levels of a number of other sensory cell types, including taste receptor cells, solitary c
  • 数据库链接：

    STRING: 10116.ENSRNOP00000039445

    UniGene: Rn.91373

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