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  4. Recombinant Rat Electrogenic sodium bicarbonate cotransporter 1 (Slc4a4), partial

Recombinant Rat Electrogenic sodium bicarbonate cotransporter 1 (Slc4a4), partial

  • 中文名称：
    大鼠Slc4a4重组蛋白
  • 货号：
    CSB-YP872837RA
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    大鼠Slc4a4重组蛋白
  • 货号：
    CSB-EP872837RA
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    大鼠Slc4a4重组蛋白
  • 货号：
    CSB-EP872837RA-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    大鼠Slc4a4重组蛋白
  • 货号：
    CSB-BP872837RA
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    大鼠Slc4a4重组蛋白
  • 货号：
    CSB-MP872837RA
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Slc4a4
  • Uniprot No.：
    Q9JI66
  • 别名：
    Slc4a4; Nbc; Nbc1; Nbce1; Rnbc1; Electrogenic sodium bicarbonate cotransporter 1; Sodium bicarbonate cotransporter; NBC-like protein; Na(+)/HCO3(-) cotransporter; Solute carrier family 4 member 4
  • 种属：
    Rattus norvegicus (Rat)
  • 蛋白长度：
    Partial
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Electrogenic sodium/bicarbonate cotransporter with a Na(+):HCO3(-) stoichiometry varying from 1:2 to 1:3. May regulate bicarbonate influx/efflux at the basolateral membrane of cells and regulate intracellular pH.; May have a higher activity than isoform 1.
  • 基因功能参考文献：
    1. Endurance training increased NHE1 and NBC1 genes and proteins expression in both Extensor digitorum longus and Soleus in the diabetic training group compared to control groups. PMID: 28719339
    2. NBCe1 is the NBC isoform activated by aldosterone in the heart PMID: 27249584
    3. NBC1 is diversely expressed in the pancreas at different developmental stages, where it may exert its functions in pancreatic development, especially islet cell growth, through HCO3(-) transport and pH regulation. PMID: 27920473
    4. Aldosterone stimulates NBC by GPR30 activation, reactive oxygen species production and AKT stimulation. PMID: 26497404
    5. Results demonstrate that transcriptional regulation and targeting of NBCe1, as well as functional operation of NBCe1, may occur through multiple signaling pathways PMID: 25755028
    6. These results revealed that insulin can stimulate PT sodium transport even in type 2 diabetes with overt nephropathy. PMID: 25866180
    7. NBCe1 hyperactivity during myocardial reperfusion leads to Na(+) and Ca(2+) loading, causing Ca(2+) overload and myocardial damage. PMID: 24721237
    8. Ang II is responsible for the impairment of the NBCe1 in hypertrophied hearts of spontaneously hypertensive rats. PMID: 24253522
    9. functionally distinct Na-HCO3 co-transporters in colon PMID: 23690961
    10. the interaction between adenosine 3',5'cyclic monophosphate, volumeregulated anion channels and NBCe1, in the regulation of insulin release from rat pancreatic islets and tumoral insulinproducing cells, was investigated. PMID: 23450392
    11. phosphatidylinositol 4,5-bisphosphate hydrolysis stimulates NBCe1-B and -C variants expressed in Xenopus laevis oocytes PMID: 22966160
    12. NBC4g mediates the efflux of HCO(3)- and contributes to cerebrospinal fluid production. PMID: 23205667
    13. study demonstrated that carbonic anhydrase IX forms a complex with extracellular loop 4 of NBCe1, which activates NBCe1-mediated bicarbonate ion influx in the myocardium PMID: 22538240
    14. NBCe1 is normally glycosylated at N597 and N617 (both on the third extracellular loop). However, N592 (on the same loop) is glycosylated when the other two sites are mutated PMID: 12604466
    15. two NH(2)-terminal NBC1 variants are co-expressed in kidney and pancreas, where they may contribute to HCO(3)(-) transport and pH regulation PMID: 14733916
    16. NBCn1 in hippocampal neurons may affect neuronal activity by regulating local pH as well as steady-state inward currents at synapses. PMID: 15718246
    17. The long-term effects of Ang-II in the proximal tubule may be mediated in part by regulation of NBC1 abundance, modifying bicarbonate reabsorption PMID: 16807546
    18. the electrogenicity of NBCe1 requires interactions between transmembrane segment 1-5 and transmembrane segment 6-13 PMID: 17038436
    19. Slc4a4 activity is enhanced during development of cardiac hypertrophy. PMID: 17416604
    20. Moreover, the data demonstrate that renal PT and salivary duct epithelia respond to acid-base disturbances by an opposite redistribution pattern for NBCe1-A and NBCe1-B. PMID: 17855492
    21. The NBCe1 current during glutamine removal was more than 50% larger than during glutamine addition, suggesting that NBCe1 enhances glutamine efflux rather than glutamine uptake PMID: 17909850
    22. An altered volume status and NaHCO(3) loading may affect the regulation of NHE3 and NBC1 in the kidney and the endogenous NO system may play a role in the observed effects. PMID: 18067590
    23. The alphaA/B primarily labeled neurons intracellularly and alphaC labeled astrocytes at the plasma membrane. In summary, the B and C variants are the predominant NBCe1 variants in rat brain and exhibit different localization profiles. PMID: 18582537
    24. Electrogenic NBCe1 (SLC4A4), but not electroneutral NBCn1 (SLC4A7), cotransporter undergoes cholinergic-stimulated endocytosis in salivary ParC5 cells. PMID: 18815229
    25. The expression of the electrogenic Na(+)-HCO(3) (-)-cotransporters NBCe1-A and NBCe1-B in rat pancreatic islet cells. PMID: 19381888
    26. Expression of the electrogenic Na(+)-HCO3(-)-cotransporter NBCe1 in tumoral insulin-producing BRIN-BD11 cells is reported. PMID: 19710533

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  • 亚细胞定位：
    Basolateral cell membrane; Multi-pass membrane protein.
  • 蛋白家族：
    Anion exchanger (TC 2.A.31) family
  • 组织特异性：
    Specifically expressed in kidney and to a lower extent in liver, lung, spleen, brain, skeletal muscle and heart. In kidney, expressed in proximal tubules at the corticomedullary junction. Isoform 2 is specifically expressed in kidney. Isoform 1 is express
  • 数据库链接：

    KEGG: rno:84484

    STRING: 10116.ENSRNOP00000004391

    UniGene: Rn.11114

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