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  4. Recombinant Rat Elastin (Eln), partial

Recombinant Rat Elastin (Eln), partial

  • 中文名称：
    大鼠Eln重组蛋白
  • 货号：
    CSB-YP007617RA
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    大鼠Eln重组蛋白
  • 货号：
    CSB-EP007617RA
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    大鼠Eln重组蛋白
  • 货号：
    CSB-EP007617RA-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    大鼠Eln重组蛋白
  • 货号：
    CSB-BP007617RA
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    大鼠Eln重组蛋白
  • 货号：
    CSB-MP007617RA
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Eln
  • Uniprot No.：
    Q99372
  • 别名：
    ElnElastin; Tropoelastin
  • 种属：
    Rattus norvegicus (Rat)
  • 蛋白长度：
    Partial
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Major structural protein of tissues such as aorta and nuchal ligament, which must expand rapidly and recover completely. Molecular determinant of the late arterial morphogenesis, stabilizing arterial structure by regulating proliferation and organization of vascular smooth muscle.
  • 基因功能参考文献：
    1. Overall, this study suggested that UC-MSCs could ameliorate aberrant elastin expression in the lung of hyperoxia-induced BPD model which may be associated with suppressing increased TGFbeta1 activation. PMID: 29242152
    2. Effects on Mmp9 and Eln mRNA expression persisted with long-term SAA treatment, resulting in decreased insoluble elastin accumulation. These data reveal a novel mechanism whereby SAA and/or infection induce changes in vascular elastin consistent with atherosclerosis. PMID: 28257481
    3. Given that elastin forms internal elastic lamina and elastic fibers in the vascular muscle layers, and that a rise in oxygen concentration reduced the secretion of elastin, this suggests that the rise in blood oxygen concentration after birth reduces the secretion of elastin, and therefore may play a role in DA structural remodeling after birth. PMID: 25970707
    4. Albuminuria is associated with increased arterial stiffness due to reduction of elastin content in the external elastic lamina. PMID: 26075500
    5. Data show that LDL-receptor related protein 1 (LRP1)-mediated cardiomyocyte intracellular cholesteryl ester accumulation alters the structural and physical characteristics of secreted tropoelastin through an increase in cathepsin S mature protein levels. PMID: 25218173
    6. Results indicate that polyphenols bind to monomeric tropoelastin and enhance coacervation, aid in crosslinking of elastin by increasing lysyl oxidase (LOX) synthesis, and by blocking MMP-2 activity. PMID: 24440697
    7. We observed little change in elastin or collagen biosynthesis in standard 2D cultures treated with ascorbate, yet observed a dramatic increase in elastin protein and mRNA levels in response to ascorbate in 3D cell-Gelfoam constructs PMID: 23648172
    8. Expression of elastin prevented cardiac dysfunction. PMID: 22435995
    9. Transplantation of elastin-secreting myoblast sheets improves cardiac function in infarcted rat heart. PMID: 22718481
    10. Macrophage-derived macrophage metalloelastase-12 regulates elastin degradation even in progressive experimental liver fibrosis. PMID: 22223197
    11. These results suggest that in an indirect co-culture system, pelvic ligament fibroblasts with mechanical stretch stimulation can promote bone mesenchymal stem cell differentiation, reflecting in the increased expression of elastin, LOX, and Fibulin-5. PMID: 22205540
    12. The mRNA and protein content of collagen I, collagen III and elastin in the abdominal aorta (AA) and femoral artery (FA) was investigated in Wistar-Kyoto rats. PMID: 21729992
    13. Lysyl oxidase is significant source of H(2)O(2) in the heart vessel wall during development and H(2)O(2) oxidatively modifies elastin producing protein blue autofluorescence. PMID: 21769453
    14. IUGR decreases elastin mRNA expression in the developing rat lung and alters elastin content and lung compliance in the mature rat lung PMID: 21363967
    15. Data sugget that in extracellular matrix, feedback between the local rate of fiber digestion and the force the fiber carries acts to attenuate any spatial heterogeneity of digestion such that molecular processes manifest directly at the macroscale. PMID: 21606336
    16. Data show that cyclic torsion upregulated expression of elastin, TNF-alpha and IL-1beta. PMID: 20736890
    17. downregulation of mRNA in lung fibroblasts by elastase-released epidermal growth factor recruitment of epidermal growth factor receptor and extracellular signal-regulated kinases PMID: 11889128
    18. the level at which elastin expression is upregulated after elastase exposure PMID: 12679320
    19. Differences in elastin organisation are a central element in small artery remodelling in hypertension. PMID: 12844513
    20. HB-EGF and FGF-2 act in concert to regulate the synthesis of elastin in injury/repair situations in pulmonary fibroblasts. PMID: 12882762
    21. activation of NF-kappaB subsequently induces inhibition of elastin gene transcription PMID: 12890646
    22. We identified on chromosomes 2 and 14, 3 quantitative trait loci(QTL) specifically controlling elastin levels, and a further highly significant QTL on chromosome 17 linked to the level of cell proteins. PMID: 15668357
    23. the ubiquitin-proteasome pathway plays an essential role in maintaining elastin gene expression in lung fibroblasts PMID: 15814588
    24. In conclusion, elastin-derived peptides and TGF-beta1 up-regulate the expression of typical bone proteins in cultured rat aortic SMCs, possibly via the ELR signaling. PMID: 16005428
    25. we conclude that neutrophil elastase initiated EGFR/MEK/ERK signaling cascade overrides the autocrine TGF-beta signaling on tropoelastin mRNA stability and, therefore, decreases the elastogenic response in RFL-6 fibroblasts PMID: 16473861
    26. TGIF is essential for EGF-mediated downregulation of tropoelastin expression PMID: 18441095

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  • 亚细胞定位：
    Secreted, extracellular space, extracellular matrix.
  • 蛋白家族：
    Elastin family
  • 数据库链接：

    KEGG: rno:25043

    STRING: 10116.ENSRNOP00000030301

    UniGene: Rn.54384

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