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  4. Recombinant Rat Complement component C6 (C6), partial

Recombinant Rat Complement component C6 (C6), partial

  • 中文名称：
    Recombinant Rat Complement component C6(C6) ,partial
  • 货号：
    CSB-YP770520RA
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    Recombinant Rat Complement component C6(C6) ,partial
  • 货号：
    CSB-EP770520RA
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    Recombinant Rat Complement component C6(C6) ,partial
  • 货号：
    CSB-EP770520RA-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    Recombinant Rat Complement component C6(C6) ,partial
  • 货号：
    CSB-BP770520RA
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    Recombinant Rat Complement component C6(C6) ,partial
  • 货号：
    CSB-MP770520RA
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    C6
  • Uniprot No.：
    Q811M5
  • 别名：
    C6Complement component C6
  • 种属：
    Rattus norvegicus (Rat)
  • 蛋白长度：
    Partial
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Constituent of the membrane attack complex (MAC) that plays a key role in the innate and adaptive immune response by forming pores in the plasma membrane of target cells.
  • 基因功能参考文献：
    1. Findings suggest that C6 deficiency by itself does not alter the regrowth capacity of the peripheral nerve after crush injury. PMID: 25011063
    2. The present study thus defines a novel role for ASK1 as a mediator of C5b-9-dependent cell injury. PMID: 18178252
    3. C6 deficiency did not lead to neuroprotection after status epilepticus PMID: 21575686
    4. The membrane attack complex of complement induces caspase activation and apoptosis. PMID: 11870622
    5. Lung allografts from C6-deficient donors to C6(-) recipients survive 13-17 days, whereas allografts from C6-sufficient donors to C6(+) recipients are rejected with intense vascular infiltration and diffuse alveolar hemorrhage 7 days posttransplant. PMID: 12370401
    6. This study demonstrates that complement component 6 is not essential for the development of proteinuria in passive Heymann nephritis. PMID: 17579035
    7. essential in the mechanism of hepatic ischemia/reperfusion injury PMID: 18668646
    8. Pathology showed improved nerve regeneration in tibials of C6 deficient animals compared to wildtypes. PMID: 19833392

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  • 亚细胞定位：
    Secreted.
  • 蛋白家族：
    Complement C6/C7/C8/C9 family
  • 数据库链接：

    KEGG: rno:24237

    UniGene: Rn.16145

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