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  4. Recombinant Rat Collagen alpha-1 (II) chain (Col2a1), partial

Recombinant Rat Collagen alpha-1 (II) chain (Col2a1), partial

  • 中文名称：
    Recombinant Rat Collagen alpha-1(II) chain(Col2a1) ,partial
  • 货号：
    CSB-YP005739RA
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    Recombinant Rat Collagen alpha-1(II) chain(Col2a1) ,partial
  • 货号：
    CSB-EP005739RA
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    Recombinant Rat Collagen alpha-1(II) chain(Col2a1) ,partial
  • 货号：
    CSB-EP005739RA-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    Recombinant Rat Collagen alpha-1(II) chain(Col2a1) ,partial
  • 货号：
    CSB-BP005739RA
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    Recombinant Rat Collagen alpha-1(II) chain(Col2a1) ,partial
  • 货号：
    CSB-MP005739RA
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Col2a1
  • Uniprot No.：
    P05539
  • 别名：
    Col2a1Collagen alpha-1(II) chain; Alpha-1 type II collagen) [Cleaved into: Collagen alpha-1(II) chain; Chondrocalcin]
  • 种属：
    Rattus norvegicus (Rat)
  • 蛋白长度：
    Partial
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Type II collagen is specific for cartilaginous tissues. It is essential for the normal embryonic development of the skeleton, for linear growth and for the ability of cartilage to resist compressive forces.
  • 基因功能参考文献：
    1. These findings suggest a novel mechanism of action of SOX5/6; namely, the SOX9/5/6 combination enhances Col2a1 transcription through a novel enhancer in intron 6 together with the enhancer in intron 1. PMID: 27881681
    2. The ERK1/2 and Smad2/3 signaling pathways regulate type II collagen and aggrecan expression in rat chondrocytes. PMID: 26165845
    3. Local adipose tissue stem cells protected the bronchial stump after pneumonectomy and induced local changes in Col2a1 gene expression. PMID: 24647564
    4. Rat collagen II citrullination decreased the adhesion of human synovial fibroblasts and rat mesenchymal stem cells by decreasing the binding of integrins alpha10beta1 and alpha11beta1 (but not alpha1beta1 and alpha2beta1)to Arg-containing motifs. It decreased MSC survival. PMID: 24823363
    5. Screening of the Col2a1 gene, and enhancer domain, for the sequence encoded regulation of its expression. PMID: 23019346
    6. While urinary C-telopeptide of type II collagen was significantly increased during the experimental periods, serum type II procollagen-C-peptide was significantly decreased at the early phase. PMID: 19000792
    7. immunohistochemical findings are consistent with the concept that the major source of serum c-telopeptide type Ii is the damaged articular cartilage in collagen-induced arthritis. PMID: 16947421
    8. Substate stiffness regulates the gene expression of Col1alpha1, Col2alpha1, aggrecan, MMP-3, MMp-13, and ADAMTS-5 in rat annular (intervertebral disc) cells. PMID: 21055467
    9. important role of Col2a1 gene strong interaction sites on Col2a1 transcription regulation by SOX9 PMID: 20404928
    10. Second harmonic generation intensity as a function of the excitation polarization angle for type I and type II collagens, was measured. PMID: 20875682
    11. study found gene transcripts of type II and X collagen were most abundant at day 10 postnatally in the spheno-occipital synchondrosis PMID: 20591638
    12. results suggest that COLII is more immunogenic and arthritogenic in an acidic environment than in a neutral environmen PMID: 15324928
    13. The present study shows the reduced Col II expression in hypothyroid rat ovary, with the concomitant increase in Col II degradation. This information will be useful for further studies on reproductive disorders. PMID: 17310101
    14. Dysregulated genes expressed in rats with surgically-induced osteoarthritis included Mmp13, Adamts5, Ptges, Cxcr4, Ccl2, and Col2a1. PMID: 17530714
    15. Cochlin may play a role in the structural homeostasis of the vestibule acting in concert with the fibrillar type II collagen bundles. PMID: 18304733
    16. During pubertal growth spurt, two-week static compression reduced caudal vertebrae growth rates; this mechanical growth modulation occurred with decreased type II and X collagen proteins in the growth plate. PMID: 18849019
    17. Data reveal that COL2 is attacked at a susceptible peptide bond at the surface of developing articular cartilage canals, and is cleaved by MMP-13. PMID: 19441084
    18. mechanical stress from a functional lateral shift of the mandible have effects the expression of type II collagen PMID: 19537875

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  • 亚细胞定位：
    Secreted, extracellular space, extracellular matrix.
  • 蛋白家族：
    Fibrillar collagen family
  • 组织特异性：
    Expressed in chondrocytes.
  • 数据库链接：

    KEGG: rno:25412

    STRING: 10116.ENSRNOP00000016044

    UniGene: Rn.10124

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