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  4. Recombinant Rat Canalicular multispecific organic anion transporter 2 (Abcc3), partial

Recombinant Rat Canalicular multispecific organic anion transporter 2 (Abcc3), partial

  • 中文名称：
    Recombinant Rat Canalicular multispecific organic anion transporter 2(Abcc3) ,partial
  • 货号：
    CSB-YP001062RA
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    Recombinant Rat Canalicular multispecific organic anion transporter 2(Abcc3) ,partial
  • 货号：
    CSB-EP001062RA
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    Recombinant Rat Canalicular multispecific organic anion transporter 2(Abcc3) ,partial
  • 货号：
    CSB-EP001062RA-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    Recombinant Rat Canalicular multispecific organic anion transporter 2(Abcc3) ,partial
  • 货号：
    CSB-BP001062RA
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    Recombinant Rat Canalicular multispecific organic anion transporter 2(Abcc3) ,partial
  • 货号：
    CSB-MP001062RA
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Abcc3
  • Uniprot No.：
    O88563
  • 别名：
    Abcc3; Cmoat2; Mlp2; Mrp3; Canalicular multispecific organic anion transporter 2; ATP-binding cassette sub-family C member 3; MRP-like protein 2; MLP-2; Multidrug resistance-associated protein 3
  • 种属：
    Rattus norvegicus (Rat)
  • 蛋白长度：
    Partial
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    ATP-dependent transporter of the ATP-binding cassette (ABC) family that bind and hydrolyze ATP to enable active transport of various substrates including many drugs, toxicants and endogenous compound across cell membranes. Transports glucuronide conjugates such as bilirubin diglucuronide, estradiol-17-beta-o-glucuronide and GSH conjugates such as leukotriene C4 (LTC4). Transports also various bile salts (taurocholate, glycocholate, taurochenodeoxycholate-3-sulfate, taurolithocholate- 3-sulfate). Does not contribute substantially to bile salt physiology but provides an alternative route for the export of bile acids and glucuronides from cholestatic hepatocytes.
  • 基因功能参考文献：
    1. This report is the first to describe liver overexpression of Abcc3 during the cancer initiation, promotion, and progression periods in rat hepatocarcinogenesis model and in human hepatocellular carcinoma PMID: 26337276
    2. Ethynylestradiol increased the expression of hepatic Mrp3 transcriptionally and independently of any cholestatic manifestation and required participation of an ER, most likely ER-alpha, through its phosphorylation. PMID: 23077105
    3. high expression of rat MRP3 in ileum and colon PMID: 11897632
    4. Efflux of F-MTX is mediated by Mrp3 on the basolateral membrane of IEC-6 cells. PMID: 12909565
    5. Conjugated bilirubin induces the mRNA expression of MRP2, which is a determinant of the in vivo cisplatin resistance of rat hepatoma cells PMID: 14981926

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  • 亚细胞定位：
    Basolateral cell membrane; Multi-pass membrane protein.
  • 蛋白家族：
    ABC transporter superfamily, ABCC family, Conjugate transporter (TC 3.A.1.208) subfamily
  • 组织特异性：
    Expressed in lung, ileum, colon and liver. Higher in liver of Eisai hyperbilirubinemic rats.
  • 数据库链接：

    KEGG: rno:140668

    UniGene: Rn.88248

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