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  4. Recombinant Rat Canalicular multispecific organic anion transporter 1 (Abcc2), partial

Recombinant Rat Canalicular multispecific organic anion transporter 1 (Abcc2), partial

  • 中文名称：
    Recombinant Rat Canalicular multispecific organic anion transporter 1(Abcc2) ,partial
  • 货号：
    CSB-YP717358RA
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    Recombinant Rat Canalicular multispecific organic anion transporter 1(Abcc2) ,partial
  • 货号：
    CSB-EP717358RA
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    Recombinant Rat Canalicular multispecific organic anion transporter 1(Abcc2) ,partial
  • 货号：
    CSB-EP717358RA-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    Recombinant Rat Canalicular multispecific organic anion transporter 1(Abcc2) ,partial
  • 货号：
    CSB-BP717358RA
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    Recombinant Rat Canalicular multispecific organic anion transporter 1(Abcc2) ,partial
  • 货号：
    CSB-MP717358RA
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Abcc2
  • Uniprot No.：
    Q63120
  • 别名：
    Abcc2; Cmoat; Cmrp; Mrp2; Canalicular multispecific organic anion transporter 1; ATP-binding cassette sub-family C member 2; Canalicular multidrug resistance protein; Multidrug resistance-associated protein 2; EC 7.6.2.2
  • 种属：
    Rattus norvegicus (Rat)
  • 蛋白长度：
    Partial
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    ATP-dependent transporter of the ATP-binding cassette (ABC) family that binds and hydrolyzes ATP to enable active transport of various substrates including many drugs, toxicants and endogenous compound across cell membranes. Transports a wide variety of conjugated organic anions such as sulfate-, glucuronide- and glutathione (GSH)-conjugates of endo- and xenobiotics substrates. Mediates hepatobiliary excretion of mono- and bis-glucuronidated bilirubin molecules and therefore play an important role in bilirubin detoxification. Mediates also hepatobiliary excretion of others glucuronide conjugates such as 17beta-estradiol 17-glucosiduronic acid and leukotriene C4. Transports sulfated bile salt such as taurolithocholate sulfate. Transport various anticancer drugs, such as anthracycline, vinca alkaloid and methotrexate and HIV-drugs such as protease inhibitors.
  • 基因功能参考文献：
    1. In conclusion, our data supports the hypothesis that isoniazid can induce liver injury via the down-regulation of hepatic efflux transporters BSEP and MRP2, and the SIRT1/FXR pathway may be the primary regulator with regard to the expression of transporters and the biosynthesis of bile acids in the liver. PMID: 30068870
    2. Bile transporters OATP1/MRP2 mRNA expression ratio in liver tissue decreased with dimethylnitrosamine-induced liver injury, model of liver cirrhosis. PMID: 27780379
    3. GLP-2 can prevent down-regulation of intestinal expression and activity of Mrp2 and P-gp in endotoxemic rats. PMID: 28842383
    4. Calculus Bovis administration can alleviate liver injury and up-regulate the expression of BSEP and MRP2 in 17alpha-ethynylestradiol-induced cholestasis by a mechanism that may involve inhibiting the activated PI3K/Akt signaling pathway. PMID: 27237619
    5. The data of this study show increased Abcc1, Abcc2, and Abcc4 mRNA expression at the BBB in response to H/R stress and that Abcc gene expression is regulated by Nrf2 signaling. PMID: 28298215
    6. results suggest that YZH has protective effect against ANIT-induced intrahepatic cholestasis in rats, through upregulation of Mrp2 and Bsep expressions PMID: 26646631
    7. Abcc2 role in cholestasis: EGFR is a key factor in the alteration of Abcc2 canalicular transporter function in hepatocytes. PMID: 25813982
    8. Serum 5-HT regulates the expression of Mrp2 and P-gp, and the underlying mechanism may be related to the altered expression of the nuclear receptor constitutive androstane receptor. PMID: 26053941
    9. These findings suggest the possibility that ABCC2-mediated hepatobiliary excretion and OATP1/OATP2-mediated hepatic uptake do not play important roles in the disposition of regorafenib. PMID: 26254357
    10. Key determinants of the circulatory exposure of organic anions: differences in hepatic uptake between multidrug resistance-associated protein 2 (Mrp2)-deficient rats and wild-type rats. PMID: 25539456
    11. Multidrug resistance-associated proteins 1, 4, 5, and Oatp1a4 were present at the transcript level, but only Mrp1, 4, and 5 were detected at the protein level. PMID: 26244301
    12. hyperammonemia increases the function and expression of P-glycoprotein and multidrug resistance-associated protein 2 at the blood-brain barrier via activating NF-kappaB pathway PMID: 25200138
    13. The pericentral downregulation of Bsep and Mrp2 following cold I/R is ameliorated by inducing HO-1 and was associated with diminished hepatocellular JNK and Fyn signaling. PMID: 23096566
    14. Gene expression and pathology changes are systematically examined in Mrp2 knockout rats for microsopic increases in the size of hepatocytes and kidney glomeruli. PMID: 23569176
    15. The utility of noninvasive DCE-MRI with Gd-EOB-DTPA as a tool for the assessment of Mrp2-deficient hyperbilirubinuria rats was demonstrated. PMID: 23442774
    16. The Multidrug Resistance-associated Protein 2 (MRP2) as a possible regulator of CP traffic and accumulation in normal and pathological conditions. PMID: 19656454
    17. Gender-related differences in pharmacokinetics of ofloxacin may be attributed to the differences in the expression of Mrp2 in kidney of male and female rats. PMID: 22812007
    18. This study aims to characterise transport of statins by human and rat MRP2/Mrp2 using membrane and vesicle preparations. PMID: 23562342
    19. Thioacetamide-induced acute liver failure increased brain MRP2 levels at 6, 12 and 24 h after induction. PMID: 22925079
    20. study shows ability of EGCG to raise plasma bile acid concentrations, mainly through Cyp7a1 upregulation, and to decrease bile production through reduction in Mrp2-mediated bile acid-independent bile flow PMID: 23146761
    21. Decreased Mrp2 transport in severe macrovesicular fatty liver grafts. PMID: 22613706
    22. hepatic transporters Ntcp and Mrp2 are downregulated in rodent models of necrotizing enterocolitis PMID: 23125159
    23. Report drug metabolizing phenotype of Mrp2 knockout rats. PMID: 22711747
    24. ABCC2 is present at the NE and perinuclear ER where, in combination with the activity of conjugating enzymes, this pump may be involved in the perinuclear barrier for small organic molecules PMID: 23041646
    25. The mechanism of JBP485 activity in cisplatin-induced acute kidney failure via changes in expression of Oat1, Oat3 and Mrp2 in rats is reported. PMID: 22992436
    26. Mrp2 acts in the rat hepatocytes as an efflux pump for amoxicillin into the bile flow. PMID: 22446938
    27. YB-1 is activated during the hepatic acute phase response. This biphasic response may explain the IL-1beta-mediated suppression of Mrp2 expression in endotoxemic rats. PMID: 22361279
    28. These findings indicate similar Abcc2 transporter expression, function, and regulation at the blood-spinal cord and blood-brain barriers. PMID: 22472606
    29. results of this study suggest the sustained periods of low GSH content coupled with altered modification of MRP2 by ubiquitin/SUMO-1 were accompanied by proteasomal degradation of MRP2 in the liver PMID: 22330094
    30. persistent elevation of serum bilirubin during regeneration of small liver was suggested to be due to sustained low uptake from the sinusoids by repressed OATP1 and low export from hepatocytes to bile duct by repressed MRP2 on the canalicular membrane. PMID: 22576625
    31. It is concluded that the pharmacokinetics of drugs that are subject to biliary excretion by the canalicular P-gp and Mrp2 transporters may be altered shortly after hepatic IR injury PMID: 22579010
    32. Orange juice and its component, hesperidin, decrease the expression of multidrug resistance-associated protein 2 in rat small intestine and liver PMID: 21660137
    33. Results suggest that sulfate conjugation, but not Mrp2, is mainly involved in the sex-related differences in the pharmacokinetics of garenoxacin. PMID: 20676911
    34. Sodium nitroprusside, but not isosorbide dinitrate, inhibited P-glycoprotein and Mrp2 via a nitric oxide independent pathway. PMID: 21198435
    35. Accumulation of organic anions in hepatocytes from rats lacking multiple resistance protein-2 (Mrp2) is similar to the same process in normal rat liver. PMID: 21131269
    36. Report that two branched polar groups and polar linker moieties of thiophene amide derivatives are essential for MRP2/ABCC2 recognition. PMID: 20738239
    37. MRP2 plays a role in the physiological handling and elimination of mercuric ions from the kidney. PMID: 21134393
    38. Lipopolysaccharide-induced cholestasis seems to be caused by posttranscriptional regulation of Mrp2, which is due to the disruption of its interaction with radixin and by its dephosphorylation. PMID: 20868650
    39. Regulation of MRP2/ABCC2 and BSEP/ABCB11 expression in sandwich cultured human and rat hepatocytes exposed to inflammatory cytokines TNF-{alpha}, IL-6, and IL-1{beta}. PMID: 20702406
    40. NHERF-1 binds to Mrp2, and plays a critical role in the canalicular expression of Mrp2 and its function as a determinant of glutathione-dependent, bile acid-independent bile flow PMID: 20404332
    41. Absence of MRP2 localization in the canalicular membrane could be the cause of the blood plasma bilirubin level increase after liver ischemia-reperfusion. PMID: 17963604
    42. Amiodarone increase renal Mdr1/Mrp2 and liver Mdr1 levels. PMID: 19703566
    43. Concomitant intake of indomethacin and sulfasalazine may lead to increased permeability of sulfasalazine in the small intestine via MRP2 inhibition, potentially decreasing the colonic concentrations of the drug. PMID: 19944137
    44. increased renal expression in a rat model of obstructive jaundice PMID: 11897625
    45. Mrp2 plays a role in regulation of chloride channel function by reducing the lag time necessary for channel activation and consequently accelerating the process of cell volume regulation (Mrp2) PMID: 12085350
    46. Ontogenic changes in bile formation are mediated in part by the regulation of expression of canalicular membrane transporter Mrp2. PMID: 12538788
    47. Although WT and Mrp2(-) hepatocytes are similar in their conjugative and oxidative metabolism of 4HNE, export of 4HNE-S-Glutathione conjugate is mediated by the MRP2 transporter, a transport system distinct from that involved in HNA efflux PMID: 12623073
    48. Multidrug resistance protein MRP2 contributes to blood-brain barrier function PMID: 12663688
    49. IL-1 beta predominates in a complex signaling network of Ntcp and Mrp2 regulation in cholestatic liver injury. PMID: 12883478
    50. CO stimulates mrp2-dependent excretion of bilirubin-IXalpha through mechanisms involving potassium channels, serving as a cooperator standing behind the heme oxygenase reaction to facilitate hepatic heme detoxification PMID: 13678533

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  • 相关疾病：
    Defects in Abcc2 are a cause of hereditary conjugated hyperbilirubinemia (EHBR).
  • 亚细胞定位：
    Apical cell membrane; Multi-pass membrane protein.
  • 蛋白家族：
    ABC transporter superfamily, ABCC family, Conjugate transporter (TC 3.A.1.208) subfamily
  • 组织特异性：
    Mainly expressed in the liver.
  • 数据库链接：

    KEGG: rno:25303

    STRING: 10116.ENSRNOP00000064799

    UniGene: Rn.10265

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