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  4. Recombinant Rat Calpain-3 (Capn3), partial

Recombinant Rat Calpain-3 (Capn3), partial

  • 中文名称：
    Recombinant Rat Calpain-3(Capn3) ,partial
  • 货号：
    CSB-YP004497RA
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    Recombinant Rat Calpain-3(Capn3) ,partial
  • 货号：
    CSB-EP004497RA
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    Recombinant Rat Calpain-3(Capn3) ,partial
  • 货号：
    CSB-EP004497RA-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    Recombinant Rat Calpain-3(Capn3) ,partial
  • 货号：
    CSB-BP004497RA
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    Recombinant Rat Calpain-3(Capn3) ,partial
  • 货号：
    CSB-MP004497RA
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Capn3
  • Uniprot No.：
    P16259
  • 别名：
    Capn3Calpain-3; EC 3.4.22.54; Calcium-activated neutral proteinase 3; CANP 3; Calpain L3; Calpain p94; Muscle-specific calcium-activated neutral protease 3
  • 种属：
    Rattus norvegicus (Rat)
  • 蛋白长度：
    Partial
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Calcium-regulated non-lysosomal thiol-protease. Proteolytically cleaves CTBP1 at 'His-399'. Mediates, with UTP25, the proteasome-independent degradation of p53/TP53.
  • 基因功能参考文献：
    1. MEF2A is a transcriptional regulator for Capn3 gene expression. PMID: 29783071
    2. the expression pattern of the active CAPN3 protein is linked to muscle atrophy and regeneration following denervation PMID: 26569227
    3. roles for Na(+) dependence of p94 PMID: 20460380
    4. role in regulating other calpain activities and causing hydrolysis of substrates such as crystallins during cataract formation PMID: 11904300
    5. Calpain 3 is specifically expressed in a subset of astrocytes and may be involved in astrocyte plasticity and/or motility. PMID: 12663060
    6. Can cleave filamin C(FLNC). FLNC may be substrate for calpain 3, regulating protein-protein interactions with sarcoglycans. Calpain-mediated remodeling of cytoskeletal-membrane interactions may involve regulation of FLNC-sarcoglycan interactions. PMID: 14506720
    7. Calpain-3 has a differential role in the early and late stages of skeletal muscle regeneration in a calcineurin-dependent manner in rats. PMID: 15726428
    8. calpain-3 remains quiescent with normal exercise but is activated following eccentric (stretching) contractions, when resting [Ca(2+)] is elevated PMID: 19144634
    9. Lp82 may function in fiber cell development and/or fiber cell remodeling during lens maturation under physiological conditions, since Lp82-mediated proteolysis occurs in the cortical region of normal lens. PMID: 12658553

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  • 亚细胞定位：
    Cytoplasm. Nucleus, nucleolus.
  • 蛋白家族：
    Peptidase C2 family
  • 组织特异性：
    Skeletal muscle.
  • 数据库链接：

    KEGG: rno:29155

    STRING: 10116.ENSRNOP00000011761

    UniGene: Rn.9726

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