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  4. Recombinant Rat Calcium-dependent secretion activator 1 (Cadps), partial

Recombinant Rat Calcium-dependent secretion activator 1 (Cadps), partial

  • 中文名称：
    Recombinant Rat Calcium-dependent secretion activator 1(Cadps) ,partial
  • 货号：
    CSB-YP717277RA
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    Recombinant Rat Calcium-dependent secretion activator 1(Cadps) ,partial
  • 货号：
    CSB-EP717277RA
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    Recombinant Rat Calcium-dependent secretion activator 1(Cadps) ,partial
  • 货号：
    CSB-EP717277RA-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    Recombinant Rat Calcium-dependent secretion activator 1(Cadps) ,partial
  • 货号：
    CSB-BP717277RA
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    Recombinant Rat Calcium-dependent secretion activator 1(Cadps) ,partial
  • 货号：
    CSB-MP717277RA
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Cadps
  • Uniprot No.：
    Q62717
  • 别名：
    Cadps; Caps; Caps1; Calcium-dependent secretion activator 1; Calcium-dependent activator protein for secretion 1; CAPS-1; rCAPS
  • 种属：
    Rattus norvegicus (Rat)
  • 蛋白长度：
    Partial
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Calcium-binding protein involved in exocytosis of vesicles filled with neurotransmitters and neuropeptides. Probably acts upstream of fusion in the biogenesis or maintenance of mature secretory vesicles. Regulates catecholamine loading of DCVs. May specifically mediate the Ca(2+)-dependent exocytosis of large dense-core vesicles (DCVs) and other dense-core vesicles by acting as a PtdIns(4,5)P2-binding protein that acts at prefusion step following ATP-dependent priming and participates in DCVs-membrane fusion. However, it may also participate in small clear synaptic vesicles (SVs) exocytosis and it is unclear whether its function is related to Ca(2+) triggering.
  • 基因功能参考文献：
    1. The unique tandem C2-PH domain of CAPS may serve as a PI(4,5)P2-triggered switch for dimerization. CAPS dimerization may be coupled to oligomeric SNARE complex assembly for vesicle docking and priming. PMID: 27528604
    2. results indicate that dense-core vesicles carry CAPS to sites of exocytosis, where CAPS promotes vesicle docking and fusion competence, probably by initiating SNARE complex assembly. PMID: 26700319
    3. Transport vesicle fusion into PIP2-rich membrane domains is facilitated by sequential PIP2-dependent activation of CAPS and PIP2-dependent recruitment of Munc13. PMID: 24356451
    4. CAPS1 binds to the full-length of cytoplasmic syntaxin-1 with preference to its "open" conformation, whereas Munc13-1 binds to the first 80 N-terminal residues of syntaxin-1. PMID: 23801330
    5. The results show that Munc13 homology domain-1 is a SNARE-binding domain and that SNARE protein binding is essential for CAPS function in dense-core vesicle exocytosis. PMID: 21803295
    6. Results suggest that SNARE complex formation promoted by CAPS may be mediated by direct interactions of CAPS with each of the three SNARE proteins required. PMID: 20826818
    7. a functional role for CAPS1 in regulating DCV trafficking in the trans-Golgi network; this activity occurs via protein-protein interaction with ARF4/ARF5 in a GDP-dependent manner. PMID: 20921225
    8. Data suggest that CAPS functions in priming vesicle exocytosis by coupling membrane binding to SNARE complexes. assembly. PMID: 19896969
    9. CAPS plays a role in the regulated exocytosis of calcium-triggered dense-core vesicles in the nervous and endocrine systems PMID: 12438120
    10. identification, cloning, and comparative characterization of a second mammalian CAPS isoform, CAPS2; concluded that at the functional level, CAPS2 is largely redundant with CAPS1. PMID: 14530279
    11. CAPS-1 functions following ATP-dependent priming as a phosphatidylinositol 4,5-diphosphate binding protein to enhance Ca2+-dependent exocytosis of dense-core vesicles. PMID: 15312653
    12. Regulation of dense core vesicle release from PC12 cells by interaction between the D2 dopamine receptor and calcium-dependent activator protein for secretion (CAPS). PMID: 15857609
    13. The three variants CaM mutants were able to activate the cyclic nucleotide phosphodiesterase and the plasma membrane Ca(2+)-ATPase,and present the characteristic Ca(2+)-induced electrophoretic mobility shift of native CaM. PMID: 15866726
    14. CAPS1 has a role in constitutive and regulated exocytosis but not in loading of transmitters into dense core vesicles PMID: 17540763
    15. CAPS proteins are involved in optimizing vesicular monoamine uptake and storage mediated by VMAT1 and VMAT2 PMID: 19008227
    16. CAPS activity in priming vesicle exocytosis requires CK2 phosphorylation PMID: 19460754

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  • 亚细胞定位：
    Cell junction, synapse. Cytoplasmic vesicle, secretory vesicle, neuronal dense core vesicle membrane; Peripheral membrane protein.
  • 组织特异性：
    Specifically expressed in neural and endocrine secretory tissues. Expressed in brain, pancreas, hypothalamus, pituitary and adrenal but not in heart, placenta, lung, liver, skeletal muscle or kidney. In brain, it is absent from the cell body layers of the
  • 数据库链接：

    KEGG: rno:26989

    STRING: 10116.ENSRNOP00000012153

    UniGene: Rn.88197

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