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  4. Recombinant Rat Atrial natriuretic peptide-converting enzyme (Corin), partial

Recombinant Rat Atrial natriuretic peptide-converting enzyme (Corin), partial

  • 中文名称：
    Recombinant Rat Atrial natriuretic peptide-converting enzyme(Corin) ,partial
  • 货号：
    CSB-YP768915RA
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    Recombinant Rat Atrial natriuretic peptide-converting enzyme(Corin) ,partial
  • 货号：
    CSB-EP768915RA
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    Recombinant Rat Atrial natriuretic peptide-converting enzyme(Corin) ,partial
  • 货号：
    CSB-EP768915RA-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    Recombinant Rat Atrial natriuretic peptide-converting enzyme(Corin) ,partial
  • 货号：
    CSB-BP768915RA
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    Recombinant Rat Atrial natriuretic peptide-converting enzyme(Corin) ,partial
  • 货号：
    CSB-MP768915RA
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Corin
  • Uniprot No.：
    Q80YN4
  • 别名：
    Corin; Atrial natriuretic peptide-converting enzyme; EC 3.4.21.-; Corin; Pro-ANP-converting enzyme) [Cleaved into: Atrial natriuretic peptide-converting enzyme; N-terminal propeptide; Atrial natriuretic peptide-converting enzyme; activated protease fragment; Atrial natriuretic peptide-converting enzyme; 180 kDa soluble fragment]
  • 种属：
    Rattus norvegicus (Rat)
  • 蛋白长度：
    Partial
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Serine-type endopeptidase involved in atrial natriuretic peptide (NPPA) processing. Converts through proteolytic cleavage the non-functional propeptide NPPA into the active hormone, thereby regulating blood pressure in heart and promoting natriuresis, diuresis and vasodilation. Proteolytic cleavage of pro-NPPA also plays a role in female pregnancy by promoting trophoblast invasion and spiral artery remodeling in uterus. Also acts as a regulator of sodium reabsorption in kidney. May also process pro-NPPB the B-type natriuretic peptide.
  • 基因功能参考文献：
    1. Corin contributes to the progression of diabetic ED and the underlying mechanism is associated with the down-regulation of ANP /NO/cGMP signal pathway. PMID: 28106289
    2. Corin mRNA and protein are downregulated in diabetic cardiomyopathy (DCM). Corin plays an important role in cardioprotection by activating pro-atrial natriuretic peptide pathway in DCM. PMID: 26446774
    3. corin might be involved in the salt retention seen in glomerular diseases. PMID: 20613715
    4. Downregulation of atrial corin mRNA expression may be a novel mechanism for the blunted ANP release in heart failure. PMID: 15155264
    5. corin gene is upregulated in hypertrophic cardiomyocytes and failing myocardium and may contribute to elevation of ANP in the setting of cardiac hypertrophy and heart failure. PMID: 15191894
    6. N-linked oligosaccharides play an important role in corin activation PMID: 17660514

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  • 亚细胞定位：
    Cell membrane; Single-pass type II membrane protein. Cytoplasmic vesicle.; [Atrial natriuretic peptide-converting enzyme, 180 kDa soluble fragment]: Secreted.
  • 蛋白家族：
    Peptidase S1 family
  • 组织特异性：
    Specifically expressed in heart. Also detected in kidney, aorta, brain and testis. In kidney, present in epithelial cells, with segmental expression in the proximal tubule, thick ascending limb, connecting tubule, and throughout the collecting duct (at pr
  • 数据库链接：

    KEGG: rno:289596

    STRING: 10116.ENSRNOP00000061602

    UniGene: Rn.211679

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