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  4. Recombinant Rat Arginase-2, mitochondrial (Arg2)

Recombinant Rat Arginase-2, mitochondrial (Arg2)

  • 中文名称：
    Recombinant Rat Arginase-2, mitochondrial(Arg2)
  • 货号：
    CSB-YP517490RA
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    Recombinant Rat Arginase-2, mitochondrial(Arg2)
  • 货号：
    CSB-EP517490RA
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    Recombinant Rat Arginase-2, mitochondrial(Arg2)
  • 货号：
    CSB-EP517490RA-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    Recombinant Rat Arginase-2, mitochondrial(Arg2)
  • 货号：
    CSB-BP517490RA
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    Recombinant Rat Arginase-2, mitochondrial(Arg2)
  • 货号：
    CSB-MP517490RA
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Arg2
  • Uniprot No.：
    O08701
  • 别名：
    Arg2Arginase-2; mitochondrial; EC 3.5.3.1; Arginase II; Kidney-type arginase; Non-hepatic arginase; Type II arginase
  • 种属：
    Rattus norvegicus (Rat)
  • 蛋白长度：
    Full Length of Mature Protein
  • 表达区域：
    23-354
  • 氨基酸序列
    VHSVAVVG APFSRGQKKK GVEYGPAAIR EAGLLKRLSM LGCHIKDFGD LSFTNVPKDD PYNNLVVYPR SVGIANQELA EVVSRAVSGG YSCVTLGGDH SLAIGTISGH ARHHPDLCVI WVDAHADINT PLTTVSGNIH GQPLSFLIRE LQDKVPQLPG FSWIKPCLSP PNLVYIGLRD VEPAEHFILK SFDIQYFSMR DIDRLGIQKV MEQTFDRLIG KRKRPIHLSF DIDAFDPKLA PATGTPVVGG LTYREGLYIT EEIHSTGLLS ALDLVEVNPH LATSEEEAKA TASLAVDVIA SSFGQTREGG HIAYDHLPTP SSPHESEKEE CVRI
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    May play a role in the regulation of extra-urea cycle arginine metabolism and also in down-regulation of nitric oxide synthesis. Extrahepatic arginase functions to regulate L-arginine bioavailability to nitric oxid synthase (NOS). Arginine metabolism is a critical regulator of innate and adaptive immune responses. Seems to be involved in negative regulation of the survival capacity of activated T cells. May suppress inflammation-related signaling in asthmatic airway epithelium. May play a role in promoting prenatal immune suppression. Regulates RPS6KB1 signaling, which promotes endothelial cell senescence and inflammation and implicates NOS3/eNOS dysfunction. Can inhibit endothelial autophagy independently of its enzymatic activity implicating mTORC2 signaling. Involved in vascular smooth muscle cell senescence and apoptosis independently of its enzymatic activity.
  • 基因功能参考文献：
    1. The present results indicate that Advanced glycation endproducts impairs endothelial-dependent vasodilation, and this effect is mediated via arginase overexpression and NADPH oxidase stimulation. PMID: 29627571
    2. Tissue-specific up-regulation of arginase I and II induced by p38 MAPK mediates endothelial dysfunction in type 1 diabetes mellitus PMID: 26140333
    3. Intermittent hypoxia increases expression levels of arginase I and II proteins in adult rats. PMID: 25490411
    4. arginase 1 and 2 inhibition augmented iNOS-dependent NO production that resulted in suppression of IL-1beta-induced vascular smooth muscle cell proliferation in a cGMP-dependent manner PMID: 23665321
    5. Arginase appears to be an essential modulator of the inflammatory response in the acute phase of a multiple sclerosis model. PMID: 22507752
    6. findings indicate that the levels of arginase 1 and 2 varied among organs, suggesting that the arginase isoforms may play organ-specific roles in the urea cycle PMID: 21975054
    7. Arg-II upregulation in aging rat hearts contributes to age-related decreased contractile function. PMID: 22160208
    8. investigation of arginase I/II expression in peritoneal macrophages of obese/lean Zucker diabetic rats, influence of arginine concentration on arginase expression in macrophages, and role of arginine/arginases in alpha-TNF/nitric oxide synthesis PMID: 22182949
    9. The data suggested that NO signaling is disrupted in neonatal rat pups exposed to even moderate hyperoxia due to increased arginase I and II activity and consequent decreased bioavailability of the substrate L-arginine. PMID: 21952491
    10. up-regulation of arginase II protein data support the conclusion that up-regulation of arginase II protein expression contributes to pulmonary artery endothelial dysfunction in this model of experimental pulmonary embolism PMID: 21281730
    11. Cerebral enzymatic activities, mRNA and protein expression of arginase and DDAH were determined in African trypanosomiasis model of rat. PMID: 21408057
    12. Arginase II levels were significantly increased in pancreases from hyperlipidemic compared with control group rats after 6 weeks of dietary intervention. PMID: 20981735
    13. study shows that increased arginase activity is not restricted to large vessels in SHRs and suggests that cardiac arginase activity is hemodynamic sensitive PMID: 19763131
    14. In contrast to Arg1, Arg2 has little effect on low-level NO production by neuronal NOS (nNOS). PMID: 11829529
    15. OAT and AII were colocalized within PST mitochondria and L-[1-14C]ornithine decarboxylation occurred in all tubules, but predominantly in proximal tubules. PMID: 14871882
    16. Intramitochondrial arginase, presumably the arginase-II isozyme, may play an important role in the regulation of hepatic ureagenesis by furnishing ornithine for net synthesis of N-acetylglutamate, citrulline, and aspartate. PMID: 15753084
    17. Mitochondrial Arg II negatively regulates NOS1 activity. PMID: 16537391
    18. Results indicate that the decreased arginase activity at mid-gestation possibly results from the down-regulation of arginase II protein. PMID: 16735458
    19. upregulation of arginase activity by Th2 cytokines during xenograft rejection limits the bioavailability of L-arginine for the inducible nitric oxide synthase PMID: 16794538
    20. Arginase II content, as well as total arginase activity, was highest in fetal rat lung, bronchi, and pulmonary arterial tissue and decreased with age (P<0.05), and its lung cell expression was developmentally regulated. PMID: 18192591
    21. Pharmacological inhibition of arginase in adult spontaneously hypertensive rats decreases blood pressure and improves the reactivity of resistance vessels. PMID: 18475148

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  • 亚细胞定位：
    Mitochondrion.
  • 蛋白家族：
    Arginase family
  • 数据库链接：

    KEGG: rno:29215

    STRING: 10116.ENSRNOP00000015083

    UniGene: Rn.11055

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