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  4. Recombinant Rat Alpha-actinin-4 (Actn4), partial

Recombinant Rat Alpha-actinin-4 (Actn4), partial

  • 中文名称：
    Recombinant Rat Alpha-actinin-4(Actn4) ,partial
  • 货号：
    CSB-YP886168RA
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    Recombinant Rat Alpha-actinin-4(Actn4) ,partial
  • 货号：
    CSB-EP886168RA
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    Recombinant Rat Alpha-actinin-4(Actn4) ,partial
  • 货号：
    CSB-EP886168RA-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    Recombinant Rat Alpha-actinin-4(Actn4) ,partial
  • 货号：
    CSB-BP886168RA
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    Recombinant Rat Alpha-actinin-4(Actn4) ,partial
  • 货号：
    CSB-MP886168RA
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Actn4
  • Uniprot No.：
    Q9QXQ0
  • 别名：
    Actn4Alpha-actinin-4; Non-muscle alpha-actinin 4
  • 种属：
    Rattus norvegicus (Rat)
  • 蛋白长度：
    Partial
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    F-actin cross-linking protein which is thought to anchor actin to a variety of intracellular structures. This is a bundling protein. Probably involved in vesicular trafficking via its association with the CART complex. The CART complex is necessary for efficient transferrin receptor recycling but not for EGFR degradation. Involved in tight junction assembly in epithelial cells probably through interaction with MICALL2. Links MICALL2 to the actin cytoskeleton and recruits it to the tight junctions. May also function as a transcriptional coactivator, stimulating transcription mediated by the nuclear hormone receptors PPARG and RARA.
  • 基因功能参考文献：
    1. Polyornithine activates alpha-Actinins 4 (ACTN4), which is firstly certified to be expessed in neural stem/progenitor cells, to promote filopodia formation and therefore enhances NSPCs migration. PMID: 27874083
    2. After 6 hours of antiorthostatic suspension alpha-actinin 1 and alpha-actinin 4 levels decreased in the membranous fraction of proteins of cardiomyocytes and soleus muscle fibers. PMID: 24780915
    3. The calcium sensitivity of alpha-actinin is required for its equatorial accumulation that is crucial for the initial equatorial actin assembly but is dispensable for cytokinesis. PMID: 22544326
    4. both high glucose and advanced glycosylation end products induce the cytoplasmic translocation and suppress the production of alpha-actinin-4 at the transcriptional level with post-translational modification in diabetic conditions PMID: 17014558
    5. Alpha-actinin-4 K256E triggers several metabolic abnormalities, which may lead to glomerular epithelial cell injury and glomerulosclerosis. PMID: 19640905

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  • 亚细胞定位：
    Nucleus. Cytoplasm. Cell junction. Cytoplasm, cytoskeleton, stress fiber. Cytoplasm, perinuclear region.
  • 蛋白家族：
    Alpha-actinin family
  • 组织特异性：
    Expressed in the foot process layer of podocytes in the kidney glomerulus but not in tubules (at protein level).
  • 数据库链接：

    KEGG: rno:63836

    STRING: 10116.ENSRNOP00000027773

    UniGene: Rn.15777

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