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  4. Recombinant Rat 25-hydroxyvitamin D-1 alpha hydroxylase, mitochondrial (Cyp27b1), partial

Recombinant Rat 25-hydroxyvitamin D-1 alpha hydroxylase, mitochondrial (Cyp27b1), partial

  • 中文名称：
    Recombinant Rat 25-hydroxyvitamin D-1 alpha hydroxylase, mitochondrial(Cyp27b1) ,partial
  • 货号：
    CSB-YP006406RA
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    Recombinant Rat 25-hydroxyvitamin D-1 alpha hydroxylase, mitochondrial(Cyp27b1) ,partial
  • 货号：
    CSB-EP006406RA
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    Recombinant Rat 25-hydroxyvitamin D-1 alpha hydroxylase, mitochondrial(Cyp27b1) ,partial
  • 货号：
    CSB-EP006406RA-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    Recombinant Rat 25-hydroxyvitamin D-1 alpha hydroxylase, mitochondrial(Cyp27b1) ,partial
  • 货号：
    CSB-BP006406RA
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    Recombinant Rat 25-hydroxyvitamin D-1 alpha hydroxylase, mitochondrial(Cyp27b1) ,partial
  • 货号：
    CSB-MP006406RA
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Cyp27b1
  • Uniprot No.：
    O35132
  • 别名：
    Cyp27b1; Cyp27b25-hydroxyvitamin D-1 alpha hydroxylase; mitochondrial; EC 1.14.15.18; 25-OHD-1 alpha-hydroxylase; 25-hydroxyvitamin D(3) 1-alpha-hydroxylase; VD3 1A hydroxylase; Calcidiol 1-monooxygenase; Cytochrome P450 subfamily XXVIIB polypeptide 1; Cytochrome P450C1 alpha; Cytochrome P450VD1-alpha; Cytochrome p450 27B1
  • 种属：
    Rattus norvegicus (Rat)
  • 蛋白长度：
    Partial
  • 表达区域：
    -
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Catalyzes the conversion of 25-hydroxyvitamin D3 (25(OH)D3) to 1-alpha,25-dihydroxyvitamin D3 (1alpha,25(OH)(2)D3), and of 24,25-dihydroxyvitamin D3 (24,25(OH)(2)D3) to 1-alpha,24,25-trihydroxyvitamin D3 (1alpha,24,25(OH)(3)D3). Is also active with 25-hydroxy-24-oxo-vitamin D3. Plays an important role in normal bone growth, calcium metabolism, and tissue differentiation.
  • 基因功能参考文献：
    1. Vascular Calcification Induced by Chronic Kidney Disease Is Mediated by an Increase of 1alpha-Hydroxylase Expression in Vascular Smooth Muscle Cells PMID: 27074284
    2. Antenatal endotoxin disrupts lung vitamin D receptor and 25-hydroxyvitamin D 1alpha-hydroxylase expression in the developing rat. PMID: 26342089
    3. Two weeks following ovariectomy, in dorsal root ganglia total CYP27B1 expression dropped significantly, predominantly due to decreased expression within unmyelinated CGRP-positive neurons. PMID: 20969950
    4. regulation of bone CYP27B1 is unique from that in the kidney, and may play an important role in bone formation PMID: 20236619
    5. catalytic activity of the CYP1alpha protein may be reduced by free radical damage in these cells PMID: 17223550
    6. Decreased expression of cyp27b1 in liver and kidney of rats exposed to 137 cesium suggests a physiological adaptation in response to rise in vitamin D level. PMID: 18797846
    7. 1alpha-hydroxylase is expressed in adipose tissue and is functional in cultured adipocytes. PMID: 18840526
    8. Data show that in type 2 diabetes mellitus or insulin resistance, insufficient renal 1-alpha hydroxylase is a precipitating factor for bone loss, and suggest that IR seems to play a major role in the pathogenesis of both IRH and bone loss in T2DM. PMID: 18979155
    9. In elderly rats with T2DM or IR, renal injury may cause decreased activity of renal 1-alpha hydroxylase, which may result in bone loss and disturbance in VD metabolism. PMID: 19542734

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  • 亚细胞定位：
    Mitochondrion membrane.
  • 蛋白家族：
    Cytochrome P450 family
  • 组织特异性：
    Kidney.
  • 数据库链接：

    KEGG: rno:114700

    STRING: 10116.ENSRNOP00000064023

    UniGene: Rn.10847

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