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  4. Recombinant Rat 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 (Plcg1), partial

Recombinant Rat 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 (Plcg1), partial

  • 中文名称：
    大鼠Plcg1重组蛋白
  • 货号：
    CSB-YP018134RA
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    大鼠Plcg1重组蛋白
  • 货号：
    CSB-EP018134RA
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    大鼠Plcg1重组蛋白
  • 货号：
    CSB-EP018134RA-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    大鼠Plcg1重组蛋白
  • 货号：
    CSB-BP018134RA
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    大鼠Plcg1重组蛋白
  • 货号：
    CSB-MP018134RA
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Plcg1
  • Uniprot No.：
    P10686
  • 别名：
    Plcg1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1; EC 3.1.4.11; Phosphoinositide phospholipase C-gamma-1; Phospholipase C-gamma-1; PLC-gamma-1
  • 种属：
    Rattus norvegicus (Rat)
  • 蛋白长度：
    Partial
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. Becomes activated in response to ligand-mediated activation of receptor-type tyrosine kinases, such as PDGFRA, PDGFRB, EGFR, FGFR1, FGFR2, FGFR3 and FGFR4. Plays a role in actin reorganization and cell migration.
  • 基因功能参考文献：
    1. These findings indicate that c-Jun induces PLCgamma1 expression transcriptionally and enhances rapid epithelial restitution after injury by activating Ca(2+) signal. PMID: 28100486
    2. These results suggest that colitis-induced and brain-derived neurotrophic factor-mediated calcitonin generelated peptide expression in sensory activation is regulated by a unique pathway involving brain-derived neurotrophic factorphospholipase C gamma-cAMP-responsive element binding protein axis. PMID: 27306412
    3. FGFR1/2 act in concert to recruit and transphosphorylate phospholipase Cgamma1. PMID: 26687682
    4. PDGF activates the GIT1PLCG1mediated ERK1/2 pathway to control chondrocyte proliferation. PMID: 25175053
    5. The content of Na(+) and K(+) in the diet regulated chromosome X levels in endothelial cells and activated PLC-gamma1 levels in rats PMID: 24785188
    6. Periodic mechanical stress promotes chondrocyte proliferation and matrix synthesis in part by activating the ERK1/2 mitogenic signal through the integrin beta 1-Src-phospholipase C-gamma-1/Rac1-ERK1/2 pathway. PMID: 22890232
    7. These data indicate that PLC-gamma1 is a target gene of GATA factors in mast cells and provide evidence that GATA1 and GATA2 control antigen-mediated mast cell degranulation by regulating the expression of PLC-gamma1. PMID: 22390417
    8. The Epo/EpoR complex plays a critical role in the adhesion and migration of rat fibroblasts, and its functional inactivation is associated with PLC-gammal-dependent reduction of cell-matrix adhesion and this also affects cell migration. PMID: 21360263
    9. Activation of FGF receptor 1 (FGFR1), largely through two key cytoplasmic amino acid residues that are linked to MAPK and PLC activation, suffices to promote adult neural stem cell self-renewal. PMID: 19505325
    10. Prolonged protein turnover of glyceraldehyde-3-phosphate dehydrogenase by phospholipase C-gamma 1 is critical for anchorage-independent growth and ATP synthesis in transformed cells. PMID: 21210726
    11. Data show that PLC-gamma isozymes link phosphorylation to phospholipase activation by elaborating upon primordial regulatory mechanisms found in other PLCs. PMID: 20807769
    12. Silencing of either c-Fos or c-Jun also depressed the norepinephrine-mediated increases in PLC beta(1), beta(3) and gamma(1) protein content and activity in an isozyme specific manner. PMID: 19538471
    13. The Y509A/F510A mutant is more susceptible to receptor tyrosine kinase-induced Y783 phosphorylation than is wild-type PLC-gamma1, but no longer requires Y783 phosphorylation step for the Y509A/F510A mutant PLC-gamma1 activation in vivo. PMID: 20164676
    14. Transfection of phosphatidylethanolamine N-methyltransferase 2 gene can inhibit the phosphorylation and translocation from cytosol to plasma membrane of PLC gamma 1. PMID: 16867273
    15. cell adhesion to alpha(1)beta(1)-specific substrates results in the association of phospholipase Cgamma (PLCgamma) with the alpha(1)beta(1) integrin independent of PLCgamma tyrosine phosphorylation PMID: 11724770
    16. acts as a guanine nucleotide exchange factor (GEF) for PIKE (phosphatidylinositol-3-OH kinase (PI(3)K) enhancer) PMID: 11823862
    17. Interaction of elongation factor-1alpha and pleckstrin homology domain of phospholipase C-gamma 1 with activating its activity PMID: 11886851
    18. Data show that motor function recovery and expression of neuronal nitric oxide synthase and phospholipase C-gamma1 was highly enhanced in regenerated nerves exposed to pulsed electromagnetic field. PMID: 11989979
    19. Phospholipase C-gamma is required for agonist-induced Ca2+ entry. PMID: 12437926
    20. Increases in PLC gamma(1) and delta(1) activities occurred upon reperfusion, but were not accounted for by altered mRNA and protein levels. The results indicate that ischemia-reperfusion induces differential changes in PLC isozymes. PMID: 12623065
    21. PLC-gamma1 directly interacts with PLD2; this interaction is important for PLC-gamma1 activity PMID: 12646582
    22. findings suggested that expression levels of phospholipase c-beta1, delta1 and gamma1 isozymes are altered by hyperoxia and acrylonitrile, but there are apparent differences in these levels between the different levels of oxidative stress and organs PMID: 12850505
    23. Phospholipase C gamma1 in distinct regions of the ventral tegmental area differentially modulates adaptations to drugs of abuse and aversive stimuli. PMID: 12930795
    24. PLCgamma function and activation are mediated by GIT1 through c-Src, which integrates signal transduction by GPCRs and TKRs PMID: 14523024
    25. The pleckstrin homology domain of Plcg1 interacts with human insulin receptor. PMID: 14568990
    26. the lipase activity of PLC-gamma1 mediates NGF-regulated MAPK signaling upstream of Ras/Rap1 activation probably through second messenger DAG-activated Ras and Rap-GEFs PMID: 14570902
    27. Tyr-783 phosphorylation of of phospholipase C-gamma 1 is not sufficient for enzyme activation PMID: 15161916
    28. Phospholipase C gamma 1 (PLCgamma1)sequestering peptides significantly impaired long-term memory, but not memory acquisition, suggesting a role for PLCgamma1-mediated signaling in spatial memory. PMID: 15169852
    29. Phospholipase C-gamma1 is a guanine nucleotide exchange factor for dynamin-1 and has a role in dynamin-1-dependent epidermal growth factor receptor endocytosis PMID: 15252117
    30. a previously unidentified mechanism for the integration of PLC-gamma1- and ERK2-dependent signaling PMID: 15258148
    31. Repeated inescapable shock decreased the expression of PLC beta1 and PLC gamma1 isozymes in the brain. PMID: 15536495
    32. results suggest that PLC-gamma1 and beta-tubulin transmodulate each other, i.e. that PLC-gamma1 modulates microtubule assembly by beta-tubulin, and beta-tubulin promotes PLC-gamma1 activity. PMID: 15579910
    33. Data reveal that the amino acid residues Pro(500) and His(503) are critical for binding of phospholipase C-gamma1 to one of its substrates, PI(4,5)P(2) in the membrane. PMID: 15607032
    34. the partial PH domain of PLC-gamma1 interacts with a complementary partial PH-like domain in TRPC3 to elicit lipid binding and cell-surface expression of TRPC3 PMID: 15744307
    35. Amino-terminal PH domain of PLC-gamma1 was identified to bind 68-kDa neurofilament light chain (NF-L). PMID: 16819285
    36. Results describe the role of phospholipase C-gamma in NGF-stimulated differentiation and gene induction. PMID: 16841466
    37. polyamine-mediated PLC-gamma1 signaling stimulates cell migration during restitution as a result of increased calcium concentration. PMID: 16973916
    38. activation of both PI3Kgamma and tyrosine kinase is a prerequisite for AII-induced stimulation of PLCgamma1 in vascular smooth muscle PMID: 16989733
    39. overexpression of PLCgamma1 stimulates MMP-3 expression at the transcriptional level via the PKC-mediated Raf/MEK1/ERK signaling cascade. PMID: 17196935
    40. It is concluded that the PLC-gamma1 protein, independently of IP3 generation and STIM1, is required to couple endoplasmic reticulum Ca2+ release to the activation of store-operated Ca2+ channels in the plasma membrane of H4IIE liver cells. PMID: 17432954
    41. Simplexvirus-mediated overexpression of PLCgamma1 in PC12 cells induced ERK activation via a mechanism dependent on protein kinases. PMID: 17524370
    42. the proliferation activity of PLC gamma1 via its SH3 domain may be coupled with the flight from growth arrest by nerve growth factors, thereby inhibiting neuronal differentiation. PMID: 17618160
    43. Activation of PLCgamma1 and subsequent Ca(2+)(i) mobilisation mediate H(2)O(2)-induced VSOR Cl(-) currents, indicating that H(2)O(2) operates via redox-sensitive signalling pathways akin to those activated by osmotic challenges. PMID: 17982259
    44. Data show that GDNF hyperalgesia is mediated by PLCgamma, MAPK/ERK, PI3K, CDK5 and Src signaling pathways, is dependent on versican, and inviolves non-peptidergic nociceptors. PMID: 18616564
    45. Nephrin Tyr-1204 phosphorylation triggers the Ca(2+) response in a PLC-gamma1-dependent fashion. PMID: 19179337
    46. Lck and c-Src kinases appear to play an important role in regulating tyrosine phosphorylation of phospholipase C1 and contractile activity in the rat uterus. PMID: 19208792
    47. EGFR-PLCgamma1 signaling mediates high glucose-induced PKCbeta1-Akt activation and collagen I upregulation in mesangial cells. PMID: 19605547

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  • 亚细胞定位：
    Cell projection, lamellipodium. Cell projection, ruffle.
  • 数据库链接：

    KEGG: rno:25738

    STRING: 10116.ENSRNOP00000022276

    UniGene: Rn.11243

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