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  4. Recombinant Rabbit hemorrhagic disease virus Genome polyprotein (ORF1), partial

Recombinant Rabbit hemorrhagic disease virus Genome polyprotein (ORF1), partial

  • 中文名称：
    Recombinant Rabbit hemorrhagic disease virus Genome polyprotein (ORF1) ,partial
  • 货号：
    CSB-YP329723RAB
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    Recombinant Rabbit hemorrhagic disease virus Genome polyprotein (ORF1) ,partial
  • 货号：
    CSB-EP329723RAB
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    Recombinant Rabbit hemorrhagic disease virus Genome polyprotein (ORF1) ,partial
  • 货号：
    CSB-EP329723RAB-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    Recombinant Rabbit hemorrhagic disease virus Genome polyprotein (ORF1) ,partial
  • 货号：
    CSB-BP329723RAB
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    Recombinant Rabbit hemorrhagic disease virus Genome polyprotein (ORF1) ,partial
  • 货号：
    CSB-MP329723RAB
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    ORF1
  • Uniprot No.：
    P27410
  • 别名：
    ORF1; Genome polyprotein; p254) [Cleaved into: Protein p16; Protein p23; NTPase; EC 3.6.1.15; 2C-like protein; P2C; p37); Precursor p41; Protein p29; Protein p23/2; Protein p18; Viral genome-linked protein; VPg; p13); 3C-like protease; 3CLpro; EC 3.4.22.66; Calicivirin; Thiol protease P3C; p15); RNA-directed RNA polymerase; EC 2.7.7.48; 3Dpol; p58); Capsid protein VP60]
  • 种属：
    Rabbit hemorrhagic disease virus (strain Rabbit/Germany/FRG/1989) (Ra/LV/RHDV/GH/1989/GE) (RHDV-FRG)
  • 蛋白长度：
    Partial
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    NTPase presumably plays a role in replication.; Viral genome-linked protein is covalently linked to the 5'-end of the positive-strand, negative-strand genomic RNAs and subgenomic RNA. Acts as a genome-linked replication primer. May recruit ribosome to viral RNA thereby promoting viral proteins translation.; 3C-like protease processes the polyprotein: 3CLpro-RdRp (p72) is first released by autocleavage, then all other proteins are cleaved.; RNA-directed RNA polymerase replicates genomic and antigenomic RNA by recognizing replications specific signals. Transcribes also a subgenomic mRNA by initiating RNA synthesis internally on antigenomic RNA. This sgRNA codes for structural proteins. Catalyzes the covalent attachment VPg with viral RNAs.; Capsid protein VP60 self assembles to form an icosahedral capsid with a T=3 symmetry, about 35 nm in diameter, and consisting of 180 capsid proteins. A smaller form of capsid with a diameter of 23 nm might be capsid proteins assembled as icosahedron with T=1 symmetry. The capsid encapsulate VP2 proteins and genomic or subgenomic RNA. Attaches virion to target cells by binding histo-blood group antigens, inducing endocytosis of the viral particle. Acidification of the endosome induces conformational change of capsid protein thereby injecting virus genomic RNA into host cytoplasm.
  • 基因功能参考文献：
    1. study identified a putative functional motif that influences the subcellular localisation of the RHDV RdRp and its ability to interfere with the organisation of the Golgi apparatus PMID: 28763035
    2. VPg serves as a novel cap substitute during the initiation of RHDV translation PMID: 26599265
    3. VP1 with an epitope insertion at the N terminus assembled into mixtures of T=3 and larger T=4 capsids. PMID: 22491457
    4. Three codons showed signs of positive selection in the major capsid protein VP60. PMID: 18761043
    5. VP2 is not essential for RHDV infectivity. [VP2] PMID: 19008396
    6. The precursor of the RNA-dependent RNA polymerase was more active than the mature polymerase. PMID: 19439553
    7. VP2 down regulates VP60 at the transcriptional level. [VP2,VP60] PMID: 19726612

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  • 亚细胞定位：
    [Capsid protein VP60]: Virion. Host cytoplasm.
  • 数据库链接：

    KEGG: vg:1491968

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