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  4. Recombinant Rabbit Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4 (HCN4), partial

Recombinant Rabbit Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4 (HCN4), partial

  • 中文名称：
    小圆锥花果HCN4重组蛋白
  • 货号：
    CSB-YP874694RB
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    小圆锥花果HCN4重组蛋白
  • 货号：
    CSB-EP874694RB
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    小圆锥花果HCN4重组蛋白
  • 货号：
    CSB-EP874694RB-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    小圆锥花果HCN4重组蛋白
  • 货号：
    CSB-BP874694RB
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    小圆锥花果HCN4重组蛋白
  • 货号：
    CSB-MP874694RB
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    HCN4
  • Uniprot No.：
    Q9TV66
  • 别名：
    HCN4; HAC4; Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4; Hyperpolarization-activated cation channel 4; HAC-4
  • 种属：
    Oryctolagus cuniculus (Rabbit)
  • 蛋白长度：
    Partial
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Hyperpolarization-activated ion channel with very slow activation and inactivation exhibiting weak selectivity for potassium over sodium ions. May contribute to the native pacemaker currents in heart (If) that regulate the rhythm of heart beat. May contribute to the native pacemaker currents in neurons (Ih). May mediate responses to sour stimuli.
  • 基因功能参考文献：
    1. HCN4-overexpressing mouse embryonic stem cell -derived cardiomyocytes produce rapid ectopic ventricular rhythms as a biological pacemaker. PMID: 29628472
    2. Ischemia-reperfusion is harmful to the sinoatrial node and reduces the expression of HCN4. PMID: 19662993
    3. SAP97 contributes to isoform specific organization of HCN channels within specific domains in the sinoatrial node of the rabbit. PMID: 19336273
    4. HCN protein expression in the rabbit pacemaker region, was investigated. PMID: 19394343
  • 亚细胞定位：
    Cell membrane; Multi-pass membrane protein.
  • 蛋白家族：
    Potassium channel HCN family
  • 组织特异性：
    Highly expressed in the heart sinoatrial node (SAN). Not detected in atrium, ventricle, forebrain or cerebellum. Detected at very low levels in total brain.
  • 数据库链接：

    KEGG: ocu:100009452

    STRING: 9986.ENSOCUP00000006294

    UniGene: Ocu.2366

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