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  4. Recombinant Protein skinhead-1 (skn-1), partial

Recombinant Protein skinhead-1 (skn-1), partial

  • 中文名称：
    秀丽隐杆线虫skn-1重组蛋白
  • 货号：
    CSB-YP339489CXY
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    秀丽隐杆线虫skn-1重组蛋白
  • 货号：
    CSB-EP339489CXY
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    秀丽隐杆线虫skn-1重组蛋白
  • 货号：
    CSB-EP339489CXY-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    秀丽隐杆线虫skn-1重组蛋白
  • 货号：
    CSB-BP339489CXY
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    秀丽隐杆线虫skn-1重组蛋白
  • 货号：
    CSB-MP339489CXY
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    skn-1
  • Uniprot No.：
    P34707
  • 别名：
    skn-1; T19E7.2; Protein skinhead-1
  • 种属：
    Caenorhabditis elegans
  • 蛋白长度：
    Partial
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Transcription factor required to specify the fate of ventral blastomeres in the early embryo, and postembryonically for the development of the intestine. Directly regulates expression of zygotically expressed med-1 and med-2 to direct mesendoderm development. Required for stl-1 mRNA up-regulation in response to oxidative stress and anoxia. Required for the up-regulation of gcs-1 and several glutathione-S-transferase mRNAs in response to oxidative stress generated during pathogenic bacterial infection. Regulates the transcription of genes associated with metabolism in response to changes in nutrient availability. In neurons, involved in mitochondrial fusion and behavioral recovery during reoxygenation. Required for riok-1 mRNA expression in the intestine. Downstream of the let-60/Ras, mek-2 and pmk-1 pathway, positively regulates lifespan probably by preventing transcription of insulin-like peptides such as ins-39. Prevents degeneration of dopaminergic CEP neurons in response to high Al(3+) or Mn(2+) levels, probably by promoting the expression of glutathione-S-transferase gst-1.; Directed by the ER-associated degradation pathway (ERAD), mediates proteasomal homeostasis by regulating the expression of proteasomal subunits such as rpt-3 to confer resistance to proteasomal dysfunction.
  • 基因功能参考文献：
    1. SKN-1 is required along with ELT-3 for the oxidative stress response. SKN-1 interacts with ELT-3. PMID: 28600327
    2. DDI-1 expression is induced by proteasome dysfunction, and the authors show that DDI-1 is required to cleave and activate an endoplasmic reticulum-associated isoform of SKN-1. PMID: 27528192
    3. The peptides from sesame cake (PSC) up-regulated skn-1 mRNA, and its target gene gcs-1, and abolished the extension of lifespan in skn-1 mutant, indicating that PSC-mediated longevity is dependent on activation of the skn-1/Nrf-2 transcription factor. PMID: 27381188
    4. Findings show that Nrf2/skn-1 is expressed in interneurons involved in chemosensation in mice and C. elegans, and that genetic deletion of skn-1 results in impaired sensory integration. The inability to activate skn-1 signaling causes the skn-1 worms to linger in inadequate food patches rather than migrate toward new potential food sources. PMID: 28459841
    5. Our data also indicate that thioallyl structure and the number of sulfur atoms are important for SKN-1 target induction. Our results indicate that SAC and SAMC may serve as potential agents that slow aging PMID: 26899496
    6. SKN-1 plays a central role in diverse genetic and pharmacologic interventions that promote C. elegans longevity, suggesting that mechanisms regulated by SKN-1 may be of conserved importance in aging PMID: 26232625
    7. The rpn-10 mutant animals survive through the activation of compensatory mechanisms regulated by the conserved SKN-1/Nrf2 and ELT-2/GATA transcription factors that mediate the increased expression of genes encoding proteasome subunits. PMID: 26828939
    8. Data show that movements of two key arginine side chains between the major groove and the backbone of DNA generate distinct conformational sub-states that each recognize only part of the consensus binding sequence of transcription factor SKN-1. PMID: 26721385
    9. The authors conclude that SKN-1 plays a direct role in maintaining lipid homeostasis in which it is activated by lipids. PMID: 26196144
    10. SKN-1 and Nrf2 has a role in linking proline catabolism with lipid metabolism during nutrient deprivation PMID: 25284427
    11. PTL-1 functions via neurons to modulate SKN-1, clarifying the role of this protein in the stress response and longevity. PMID: 25399685
    12. A network analysis of aging-associated miRNAs connected to transcription factors PHA-4/FOXA and SKN-1/Nrf revealed extensive regulatory interactions between PHA-4, SKN-1, and miRNAs undergoing dietary restriction. PMID: 25242029
    13. Anoxia results in mitochondrial oxidative stress, and the oxidative response factor SKN-1/Nrf is required for both rapid mitochondrial refusion and rapid behavioral recovery during reoxygenation PMID: 24385935
    14. studies suggest that knockdown of skn-1 in the nematode increases DAergic sensitivity to MeHg exposure following a period of latency PMID: 24194349
    15. our results suggest that SKN-1 activation in the nervous system can confer protection to organisms in response to stress by directly regulating nlg-1/neuroligin expression. PMID: 24453991
    16. Regulatory integration through SKN-1/Nrf may coordinate ER and cytoplasmic homeostasis. PMID: 24068940
    17. genetic inactivation of rict-1 suppressed skn-1-associated lethality by restoring mesendodermal specification in skn-1 deficient embryos PMID: 23973804
    18. These results provide insight into how SKN-1/Nrf2 might protect the nervous system from damage in response to oxidative stress. PMID: 23555279
    19. SKN-1/Nrf functions in an evolutionarily conserved pathway to modulate metabolism and adaptation to starvation. PMID: 23040073
    20. Mutations in skn-1 and knockdown of genes encoding phase II detoxification enzymes led to increased sterility in the presence of dietary dihomo-gamma-linolenic acid. PMID: 23064027
    21. discussion of structure and function of SKN-1 in relation to drug resistance to anthelminthic agents; includes amino acid sequence alignment/homology and phylogeny [REVIEW] PMID: 22656429
    22. SKN-1 contributes to the enhanced oxidative stress resistance incurred by hcf-1 mutation PMID: 22568582
    23. SKN-1, as a novel regulator of innate immunity, involves in immunosenescence and provides an important crosstalk between pathogenic stress signaling and the xenobiotic/oxidative stress response. PMID: 22577361
    24. Mutation or silencing of WDR-46 activates the single C. elegans CnC homologue SKN-1 and increases expression of its target genes. PMID: 22240150
    25. a reduction in SKN-1 gene expression increases MeHg-induced animal vulnerability and dopamine neuron degeneration. PMID: 20855423
    26. SKN-1 detoxification gene network monitors various metabolic and regulatory processes. PMID: 20700440
    27. the ERK (MPK-1) cascade-mediated life span extension requires SKN-1, whose function is mediated, at least partly, through DAF-2/DAF-16 insulin-like signaling. MPK-1 phosphorylates SKN-1 on the key sites that are required for SKN-1 nuclear accumulation. PMID: 20624915
    28. Results show that cell stress triggers aip-1 expression by both skn-1-dependent and -independent pathways. PMID: 20351174
    29. SKN-1 represents a connection between developmental specification of the digestive system and resistance to oxidative and xenobiotic stress PMID: 12869585
    30. med transcripts accumulate both in the EMS cell and in the maternal germline in a SKN-1-dependent manner PMID: 16979152
    31. EEL01 controls asymmetry and persistence of Skn-1 in the early C. elegans embryo. PMID: 17537795
    32. increased longevity of diet-restricted Caenorhabditis elegans requires the transcription factor gene skn-1 acting in the ASIs, a pair of neurons in the head PMID: 17538612
    33. we have identified four kinases, MKK-4, IKK epsilon-1, NEKL-2, and PDHK-2, which are necessary for the nuclear localization of SKN-1 in response to oxidative stress PMID: 17964427
    34. The findings indicate that the transcription network regulated by SKN-1 promotes longevity and is an important direct target of Insulin/IGF-1-like signaling. PMID: 18358814
    35. Striking complexity in SKN-1 functions and the regulation of systemic detoxification defenses in Caenorhabditis elegans. PMID: 19575768
    36. findings showed that a transcriptional shift from growth and maintenance towards the activation of cellular defense mechanisms was caused by the oxidative stress; many of these transcriptional alterations are SKN-1 dependent. PMID: 19627265

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  • 亚细胞定位：
    Nucleus. Cytoplasm.; [Isoform a]: Nucleus. Mitochondrion.
  • 蛋白家族：
    BZIP family, Skn1 subfamily
  • 组织特异性：
    Postembryonic intestinal cells.
  • 数据库链接：

    KEGG: cel:CELE_T19E7.2

    STRING: 6239.T19E7.2a.2

    UniGene: Cel.23037

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