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  4. Recombinant Pig Sodium/potassium-transporting ATPase subunit alpha-1 (ATP1A1), partial

Recombinant Pig Sodium/potassium-transporting ATPase subunit alpha-1 (ATP1A1), partial

  • 中文名称：
    Recombinant Pig Sodium/potassium-transporting ATPase subunit alpha-1(ATP1A1) ,partial
  • 货号：
    CSB-YP002322PI
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    Recombinant Pig Sodium/potassium-transporting ATPase subunit alpha-1(ATP1A1) ,partial
  • 货号：
    CSB-EP002322PI
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    Recombinant Pig Sodium/potassium-transporting ATPase subunit alpha-1(ATP1A1) ,partial
  • 货号：
    CSB-EP002322PI-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    Recombinant Pig Sodium/potassium-transporting ATPase subunit alpha-1(ATP1A1) ,partial
  • 货号：
    CSB-BP002322PI
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    Recombinant Pig Sodium/potassium-transporting ATPase subunit alpha-1(ATP1A1) ,partial
  • 货号：
    CSB-MP002322PI
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    ATP1A1
  • Uniprot No.：
    P05024
  • 别名：
    ATP1A1Sodium/potassium-transporting ATPase subunit alpha-1; Na(+)/K(+) ATPase alpha-1 subunit; EC 7.2.2.13; Sodium pump subunit alpha-1
  • 种属：
    Sus scrofa (Pig)
  • 蛋白长度：
    Partial
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    This is the catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of sodium and potassium ions across the plasma membrane. This action creates the electrochemical gradient of sodium and potassium ions, providing the energy for active transport of various nutrients.
  • 基因功能参考文献：
    1. This study determined the specificity of the interaction between the N-terminus of the alpha-subunit of the Na+,K+-ATPase and the surrounding membrane. PMID: 29522705
    2. The findings are consistent with previous studies that indicate a link between Na,K-ATPase activity and SFK signaling. PMID: 27748508
    3. Uroguanylin modulates (Na++K+)ATPase in a proximal tubule cells via cGMP/protein kinase G, cAMP/protein kinase A, and mTOR pathways. PMID: 27102282
    4. Data indicate that magnesium fluoride, magnesium fluoride and Na,K-ATPase form a very stable complex in the E2 conformation. PMID: 25838127
    5. Data indicate that Rb(+) can be occluded through Na(+)/K(+)-ATPase cycling mode that takes place in the absence of Na(+) ions. PMID: 23357355
    6. Expression of mutant alpha1 Na/K-ATPase defective in conformational transition attenuates Src-mediated signal transduction PMID: 23288841
    7. re-arrangements of the Na+,K+-ATPase stabilized by cardiotonic steroids may affect protein-protein interactions within the intracellular signal transduction networks PMID: 21182963
    8. Data indicate that the transmembrane domain of the Na+/K+ -ATPase in the E1 state is less exposed to the lipids than in E2. PMID: 21419126
    9. The plasma membrane Na/K-ATPase-caveolin-1 interaction may represent an important sensing mechanism by which the cells regulate the sterol regulatory element-binding protein pathway. PMID: 19363037
    10. Investigations of K(+)-occlusion by the phosphoenzyme of Na(+),K(+)-ATPase from shark rectal gland and pig kidney by stopped-flow fluorimetry reveal major differences in the kinetics of the two enzymes. PMID: 21190658
    11. The results indicate that PKC could be the final target and an integrator molecule of different signaling pathways triggered by angiotensin II (Ang II), which could explain the sustained activation of Na(+)-ATPase by Ang II. PMID: 19958748
    12. Na,K-ATPase is a new target of TGF-beta(1)-mediated Epithelial-to-mesenchymal transition in renal epithelial cells, a model system used in studies of both cancer progression and fibrosis. PMID: 20501797
    13. Adenosine triphosphate binding to the E2P (intermediate) stage of the enzyme pump cycle causes a deceleration in its dephosphorylation when acting in the sodium ion (Na)+-ATPase mode, i.e., in the absence of monovalent potassium (K+) ions. PMID: 20063899
    14. Results provide evidence for interaction of aspartic acid 443 in the N domain of Na(+),K(+)-ATPase with a magnesium ion. PMID: 16331955
    15. addressed the question of how modification of the cholesterol content could affect the ATPase activity via changes in the membrane lipid phase and in the protein structure and dynamics PMID: 17105204
    16. Neutralization of the charge on Asp 369 of Na+,K+-ATPase triggers conformational changes. PMID: 19726667

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  • 亚细胞定位：
    Basolateral cell membrane; Multi-pass membrane protein. Cell membrane, sarcolemma; Multi-pass membrane protein. Cell projection, axon. Melanosome.
  • 蛋白家族：
    Cation transport ATPase (P-type) (TC 3.A.3) family, Type IIC subfamily
  • 数据库链接：

    KEGG: ssc:397481

    STRING: 9823.ENSSSCP00000007190

    UniGene: Ssc.12630

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