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  4. Recombinant Pig POU domain, class 5, transcription factor 1 (POU5F1)

Recombinant Pig POU domain, class 5, transcription factor 1 (POU5F1)

  • 中文名称：
    野猪POU5F1重组蛋白
  • 货号：
    CSB-YP879986PI
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    野猪POU5F1重组蛋白
  • 货号：
    CSB-EP879986PI
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    野猪POU5F1重组蛋白
  • 货号：
    CSB-EP879986PI-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    野猪POU5F1重组蛋白
  • 货号：
    CSB-BP879986PI
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    野猪POU5F1重组蛋白
  • 货号：
    CSB-MP879986PI
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    POU5F1
  • Uniprot No.：
    Q9TSV5
  • 别名：
    POU5F1; OCT3; OCT4; POU domain; class 5; transcription factor 1; Octamer-binding protein 3; Oct-3; Octamer-binding protein 4; Oct-4; Octamer-binding transcription factor 3; OTF-3
  • 种属：
    Sus scrofa (Pig)
  • 蛋白长度：
    full length protein
  • 表达区域：
    1-360
  • 氨基酸序列
    MAGHLASDFA FSPPPGGGGD GPGGPEPGWV DPRTWLSFQG PPGGSGIGPG VGPGAEVWGL PACPPPYDFC GGMAYCAPQV GVGLVPQGGL ETPQPEGEAG AGVESNSEGA SPEPCAAPAG AAKLDKEKLE PNPEESQDIK ALQKDLEQFA KLLKQKRITL GYTQADVGLT LGVLFGKVFS QTTICRFEAL QLSFKNMCKL RPLLQKWVEE ADNNENLQEI CKAETLVQAR KRKRTSIENR VRGNLESMFL QCPKPTLQQI SHIAQQLGLE KDVVRVWFCN RRQKGKRSSS DYSQREDFEA AGSPFPGGPV SFPLAPGPHF GTPGYGGPHF TTLYSSVPFP EGEAFPSVSV TPLGSPMHSN
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Transcription factor that binds to the octamer motif (5'-ATTTGCAT-3'). Forms a trimeric complex with SOX2 or SOX15 on DNA and controls the expression of a number of genes involved in embryonic development such as YES1, FGF4, UTF1 and ZFP206. Critical for early embryogenesis and for embryonic stem cell pluripotency.
  • 基因功能参考文献：
    1. Activin A and overexpression of SMAD2/3 significantly promoted expressions of porcine NANOG and OCT4,maintaining induced pluripotent stem cell self-renewal through up-regulation of Nanog/OCT4 expression. PMID: 27996082
    2. Our results indicate that continuous expression of OCT-4 in blastomeres is essential for trophectoderm formation of porcine embryos. PMID: 27210587
    3. These findings suggest that the 12-bp indel polymorphism of the Oct4 gene might be a potential DNA marker for selecting preferred individuals in relation to reproductive traits in pig marker-assisted selection breeding. PMID: 28139300
    4. Oct4-overexpression enhances porcine ovarian stem cell differentiation in to oocyte-like cells. PMID: 27067537
    5. showed novel molecular regulation of CDX2 on Oct4, and provided important clues for clarifying the mechanism of interaction between CDX2 and Oct4 in embryo of mammals other than mouse PMID: 26708097
    6. Overexpression of Sox2 or Oct4 in bone mesenchymal stem cells in culture media containing a basic fibroblast growth factor results in higher proliferation and differentiation compared to controls. PMID: 24338401
    7. Oct4 positive stem/progenitor swine lung epithelial cells are targets for influenza virus replication. PMID: 22491467
    8. study shows that localization of octamer-binding protein 4(OCT4) is associated with an embryonic stem cell (ESC)-like morphology from porcine inner cell mass PMID: 20663092
    9. OCT4 expression, in contrast to earlier speculations, at least in hatched blastocysts, resembles the expression pattern in the mouse embryo. PMID: 21089074
    10. cells isolated from umbilical cord express three transcription factors,Oct-4, Sox-2 & Nanog, found in pluripotent stem cell markers both at the mRNA and protein level. PMID: 16460563
    11. in the forming endoderm at the primitive streak stage, OCT4 was detectable in potential primordial germ cells only; in the ectoderm and mesodermal cell lineages OCT4 was cleared at the neural groove and somite stage, respectively PMID: 16541449

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  • 亚细胞定位：
    Cytoplasm. Nucleus.
  • 蛋白家族：
    POU transcription factor family, Class-5 subfamily
  • 数据库链接：

    KEGG: ssc:100127461

    STRING: 9823.ENSSSCP00000001474

    UniGene: Ssc.29069

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