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  4. Recombinant Osmotic avoidance abnormal protein 3 (osm-3), partial

Recombinant Osmotic avoidance abnormal protein 3 (osm-3), partial

  • 中文名称：
    秀丽隐杆线虫osm-3重组蛋白
  • 货号：
    CSB-YP343613CXY
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    秀丽隐杆线虫osm-3重组蛋白
  • 货号：
    CSB-EP343613CXY
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    秀丽隐杆线虫osm-3重组蛋白
  • 货号：
    CSB-EP343613CXY-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    秀丽隐杆线虫osm-3重组蛋白
  • 货号：
    CSB-BP343613CXY
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    秀丽隐杆线虫osm-3重组蛋白
  • 货号：
    CSB-MP343613CXY
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    osm-3
  • Uniprot No.：
    P46873
  • 别名：
    osm-3; M02B7.3; Osmotic avoidance abnormal protein 3; Kinesin-like protein osm-3
  • 种属：
    Caenorhabditis elegans
  • 蛋白长度：
    Partial
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Kinesin motor protein which is required for the anterograde intraflagellar transport (IFT) along the middle segment of the sensory neuron cilia together with the kinesin II motor complex (composed of klp-11, klp-20 and kap-1) and on its own, is required for IFT along the distal segment. In addition, regulates the length of cilia. May have a role during neurogenesis and axonal transport.
  • 基因功能参考文献：
    1. OSM-3 mutations cause NPHP-4 dependent and independent phenotypes. PMID: 26863025
    2. Data show that kinesin-II and OSM-3 facilitate ciliary import and long-range transport. PMID: 26523365
    3. Dauer pheromone and gpa-3 signaling modulate the coordination of intraflagellar transport of kinesin-II and OSM-3. PMID: 20501698
    4. OSM-3 is an accessory intraflagellar transport (IFT) kinesin motor; subtle changes in its deployment or actions can contribute to differences in cilia morphology, cilia function, and sensory perception. PMID: 16492809
    5. Wild-type worms are induced to display an L1 (first larval stage) surface epitope at later larval stages when grown on an extract of spent culture medium; this was abolished in chemotaxis-defective osm-3 mutants. PMID: 16879619
    6. In this study, using a single-molecule fluorescence assay, the investigators show that bacterially expressed OSM-3 in solution does not move processively and displays low microtubule-stimulated adenosine triphosphatase (ATPase) activity. PMID: 17000874

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  • 亚细胞定位：
    Cytoplasm, cytoskeleton. Cell projection, cilium. Cytoplasm, cytoskeleton, cilium axoneme. Cytoplasm, cytoskeleton, cilium basal body.
  • 蛋白家族：
    TRAFAC class myosin-kinesin ATPase superfamily, Kinesin family, Kinesin II subfamily
  • 组织特异性：
    Expressed in an exclusive set of 26 chemosensory neurons whose dendritic endings are exposed to the external environment; six IL2 neurons of the inner labial sensilla, 8 pairs of amphid neurons in the head, and 2 pairs of phasmid neurons in the tail.
  • 数据库链接：

    KEGG: cel:CELE_M02B7.3

    STRING: 6239.M02B7.3b

    UniGene: Cel.12541

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