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  4. Recombinant Nuclear hormone receptor family member nhr-49 (nhr-49), partial

Recombinant Nuclear hormone receptor family member nhr-49 (nhr-49), partial

  • 中文名称：
    秀丽隐杆线虫nhr-49重组蛋白
  • 货号：
    CSB-YP528604CXY
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    秀丽隐杆线虫nhr-49重组蛋白
  • 货号：
    CSB-EP528604CXY
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    秀丽隐杆线虫nhr-49重组蛋白
  • 货号：
    CSB-EP528604CXY-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    秀丽隐杆线虫nhr-49重组蛋白
  • 货号：
    CSB-BP528604CXY
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    秀丽隐杆线虫nhr-49重组蛋白
  • 货号：
    CSB-MP528604CXY
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    nhr-49
  • Uniprot No.：
    O45666
  • 别名：
    nhr-49; K10C3.6; Nuclear hormone receptor family member nhr-49
  • 种属：
    Caenorhabditis elegans
  • 蛋白长度：
    Partial
  • 表达区域：
    1-501
  • 氨基酸序列
    MDYFLDASKH IQLNQIDEES SDDFMDLVDP LAEPCAVCGD KSTGTHYGVI SCNGCKGFFR RTVLRDQKFT CRFNKRCVID KNFRCACRYC RFQKCVQVGM KREAIQFERD PVGSPTSGAS LNGTPFKKDR SPGYENGNSN GVGSNGMGQE NMRTVPQSSS VIDALMEMEA RVNQEMCNRY RRSQIFANGS GGSNGNDTDI QQGSDSGASA FAPPNRPCTT EVDLNEISRT TLLLMVEWAK TINPFMDLSM EDKIILLKNY APQHLILMPA FRSPDTTRVC LFNNTYMTRD NNTDLNGFAA FKTSNITPRV LDEIVWPMRQ LQMREQEFVC LKALAFLHPE AKGLSNSSQI MIRDARNRVL KALYAFILDQ MPDDAPTRYG NILLLAPALK ALTQLLIENM TLTKFFGLAE VDSLLSEFIL DDINDHSTAP VSLQQHLSSP TTLPTNGVSP LNPAGSVGSV SSVSGITPTG MLSATLAAPL AIHPLQSQDS ILNSEQNNHM L
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Orphan nuclear receptor. Regulates expression of lipid desaturase, fat-7.
  • 基因功能参考文献：
    1. Reduced signaling through the insulin-like receptor daf-2/InsR in the maternal soma causes constitutively large progeny, and its effector daf-16/FoxO is required for this effect. nhr-49/Hnf4, pha-4/FoxA, and skn-1/Nrf also regulate progeny-size plasticity. Genetic analysis suggests that insulin-like signaling controls progeny size in part through regulation of nhr-49/Hnf4, and that pha-4/FoxA and skn-1/Nrf function PMID: 27783623
    2. AAK-2 regulates oxidative metabolism in Caenorhabditis elegans through the NHR-49 and MDT-15 transcriptional regulators. PMID: 26824904
    3. NHR-49 may facilitate the adaptation to loss of reproductive potential through synchronized enhancement of fatty-acid oxidation and desaturation,and orchestrating a lipid profile conducive for somatic maintenance and longevity. PMID: 25474470
    4. Data (including data from studies in mutant and transgenic strains) suggest that stress response to fasting (lysosomal lipid accumulation) is co-ordinately regulated by EGL-4/PKG (protein kinase G) and nuclear hormone receptor NHR-49. PMID: 24854345
    5. Fibrates promote C. elegans longevity in an NHR-49-dependent manner possibly by promoting mitohormesis and suggesting that these compounds may promote lifespan also in mammals. PMID: 23603800
    6. Caenorhabditis elegans NHR gene nhr-49 yielded worms with elevated fat content and shortened life span. PMID: 15719061
    7. Knockdown of mdt-15 by RNA interference (RNAi) prevented fasting-induced mRNA accumulation of NHR-49 targets in vivo, and fasting-independent expression of other NHR-49 target genes. PMID: 16651656
    8. nhr-49 has a role in regulating lipid synthesis, beta-oxidation of fatty acids, glycolysis and gluconeogenesis in a similar manner to the role of PPAR-alpha in the mouse liver. PMID: 18435929
    9. findings show the starvation-sensing nuclear receptor NHR-49 is required for adult reproductive diapause entry and recovery PMID: 19713489

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  • 亚细胞定位：
    Nucleus.
  • 蛋白家族：
    Nuclear hormone receptor family
  • 数据库链接：

    KEGG: cel:CELE_K10C3.6

    STRING: 6239.K10C3.6c.2

    UniGene: Cel.17842

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